Study for preventing epidemic of viral zoonoses in Japan and theAmerican Continents

• Project/Area Number: 21405035
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Applied veterinary science
• Research Institution: Hokkaido University
• Principal Investigator: KARIWA Hiroaki 北海道大学, 大学院・獣医学研究科, 准教授 (70224714)
• Co-Investigator(Kenkyū-buntansha): ARIKAWA Jiro 北海道大学, 大学院・医学研究科, 教授 (10142704) ; YOSHII Kentaro 北海道大学, 大学院・獣医学研究科, 助教 (50421988) ; MORIMATSU Kumiko 北海道大学, 大学院・医学研究科, 准教授 (90220722) ; 高島 郁夫 北海道大学, 大学院・獣医学研究科, 教授 (30002083)
• Project Period (FY): 2009 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000); Fiscal Year 2012: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2011: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2010: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2009: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
• Keywords: 人獣共通感染症 / ハンタウイルス / ウエストナイルウイルス / げっ歯類 / 鳥類 / メキシコ

Research Abstract

Three novel hantaviruses were detected in Mexican rodents. The antibody detection method for various hantavirus infections was developed. Five of six monoclonal antibodies to nucleocapsid protein (NP) of Mexican hantavirus were broadly reacted with NPs of rodent-borne hantaviruses. Glycosylation of West Nile virus E protein made great influence in the pathogenesis in chicks infected with West Nile virus.

Research Products

• [Journal Article] Infection of Hantaan virus strain AA57 leading to pulmonary disease in laboratory mice (2012)
  • Author(s): Seto T, Yoshii K, Kariwa H.
  • Journal Title: Virus Res Volume: 163 Pages: 284-290
  • Peer Reviewed
• [Journal Article] Genetic diversity of hantaviruses inMexico: Identification of three novel hantaviruses from Neotominae rodents (2012)
  • Author(s): Kariwa H, Yoshii K, Yoshimatsu K, Arikawa J
  • Journal Title: Virus Res Volume: 163 Pages: 486-494
  • Peer Reviewed
• [Journal Article] Isolation and characterization of hantaviruses in far East Russia and etiology of hemorrhagic Fever with renal syndrome in the region (2012)
  • Author(s): Kariwa H, Yoshimatsu K, Arikawa J, Yoshii K
  • Journal Title: Am J Trop Med Hyg Volume: 86 Pages: 545-553
  • Peer Reviewed
• [Journal Article] The Conserved Region in the PrM Protein Is a Critical Determinant in the Assembly of Flavivirus Particles (2012)
  • Author(s): Yoshii K, Kariwa H, Takashima I
  • Journal Title: J Gen Virol Volume: 93 Pages: 27-38
  • Peer Reviewed
• [Journal Article] The N-terminus of the Montano virus nucleocapsid protein possesses broadly cross-reactive conformation- dependent epitopes conserved in rodent- borne hantaviruses (2012)
  • Author(s): Saasa N, Yoshii K, Yoshimatsu K, ArikawaJ, Kariwa H
  • Journal Title: Virology Volume: 428 Pages: 48-57
  • Peer Reviewed
• [Journal Article] Ecology of hantaviruses inMexico: Genetic identification of rodent host species and spillover infection (2012)
  • Author(s): Saasa N, Yoshii K, Yoshimatsu K, ArikawaJ, Kariwa H
  • Journal Title: Virus Res Volume: 168 Pages: 88-96
  • Peer Reviewed
• [Journal Article] Development of a diagnostic method applicable to various serotypes of hantavirus infection in rodents (2012)
  • Author(s): Sanada T, Kariwa H, Yoshimatsu K, Arikawa J, Yoshii K
  • Journal Title: J Vet Med Sci Volume: 74 Pages: 1237-1242
  • NAID: 130001879747
  • Peer Reviewed
• [Journal Article] Isolation of Hokkaido virus, genus Hantavirus, using a newlyestablished cell line derived from the kidney of the grey red-backed vole (Myodes rufocanus bedfordiae) (2012)
  • Author(s): Sanada T, Yoshimatsu K, Arikawa J, Yoshii K, Kariwa H
  • Journal Title: J Gen Virol Volume: 93 Pages: 2237-2246
  • Peer Reviewed
• [Journal Article] 2008年北海道におけるダニ媒介性脳炎ウイルスの分離と性状解析 (2012)
  • Author(s): 好井健太朗, 山崎翔子, 持舘景太, 苅和宏明, 高島郁夫
  • Journal Title: 獣医畜産新報 Volume: 65 Pages: 377-378
• [Journal Article] Genetic diversity of hantaviruses in Mexico: identification of three novel hantaviruses from Neotominae rodents (2012)
  • Author(s): Kariwa H
  • Journal Title: Virus Res Volume: 163 Issue: 2 Pages: 486-494
  • DOI: 10.1016/j.virusres.2011.11.013
  • Peer Reviewed
• [Journal Article] Isolation and characterization of hantaviruses in Far East Russia and etiology of hemorrhagic fever with renal syndrome in the region (2012)
  • Author(s): Kariwa H
  • Journal Title: Am J Trop Med Hyg Volume: 86 Issue: 3 Pages: 545-553
  • DOI: 10.4269/ajtmh.2012.11-0297
  • Peer Reviewed
• [Journal Article] The N-terminus of the Montano virus nucleocapsid protein possesses broadly cross-reactive conformation-dependent epitopes conserved in rodent-borne hantaviruses (2012)
  • Author(s): Saasa N
  • Journal Title: Virology Volume: 428 Issue: 1 Pages: 48-57
  • DOI: 10.1016/j.virol.2012.03.001
  • Peer Reviewed
• [Journal Article] Development of a serotyping enzyme-linked immunosorbent assay system based on recombinant truncated hantavirus nucleocapsid proteins for New World hantavirus infection (2012)
  • Author(s): Koma T
  • Journal Title: J Virol Methods Volume: 185 Issue: 1 Pages: 74-81
  • DOI: 10.1016/j.jviromet.2012.06.006
  • Peer Reviewed
• [Journal Article] Ecology of hantaviruses in Mexico: genetic identification of rodent host species and spillover infection (2012)
  • Author(s): Saasa N
  • Journal Title: Virus Res Volume: 168 Issue: 1-2 Pages: 88-96
  • DOI: 10.1016/j.virusres.2012.06.020
  • Peer Reviewed
• [Journal Article] Isolation of Hokkaido virus, genus Hantavirus, using a newly established cell line derived from the kidney of the grey red-backed vole (Myodes rufocanus bedfordiae) (2012)
  • Author(s): Sanada T
  • Journal Title: J Gen Virol Volume: 93 Issue: 10 Pages: 2237-2246
  • DOI: 10.1099/vir.0.045377-0
  • Peer Reviewed
• [Journal Article] Infection of Hantaan virus strain AA57 leading to pulmonary disease in laboratory mice (2012)
  • Author(s): Seto T, et al.
  • Journal Title: Virus Res Volume: 163 Pages: 284-90
  • Peer Reviewed
• [Journal Article] Genetic diversity of hantaviruses in Mexico : identification of three Novel hantaviruses from Neotominae rodents (2012)
  • Author(s): Kariwa H, et al.
  • Journal Title: Virus Res Volume: 163 Pages: 486-94
  • Peer Reviewed
• [Journal Article] Isolation and characterization of hantaviruses in far East Russia and etiology of hemorrhagic Fever with renal syndrome in the region (2012)
  • Author(s): Kariwa H, et al.
  • Journal Title: Am J Trop Med Hyg Volume: 86 Pages: 545-53
  • Peer Reviewed
• [Journal Article] Construction of an infectious cDNA clone for Omsk hemorrhagic fever virus, and characterization of mutations in NS2A and NS5 (2011)
  • Author(s): Yoshii K, IKariwa H, Takashima I
  • Journal Title: Virus Res Volume: 155 Pages: 61-68
  • NAID: 120002834769
  • Peer Reviewed
• [Journal Article] Epizootiological Study of Tick-Borne Encephalitis Virus Infection in Japan (2011)
  • Author(s): Yoshii K, Kariwa H, Takashima I
  • Journal Title: J Vet Med Sci Volume: 73 Pages: 409-412
  • NAID: 130000444345
  • Peer Reviewed
• [Journal Article] An Efficient in vivo Method for the Isolation OF Puumala Virus in Syrian Hamsters and the Characterization of the isolates from Russia (2011)
  • Author(s): Seto T, Yoshii K, Yoshimatsu K, Arikawa J, Kariwa H
  • Journal Title: J Virol Methods Volume: 173 Pages: 17-23
  • Peer Reviewed
• [Journal Article] Development of ELISA system for tick-borne encephalitis virusinfection in rodents (2011)
  • Author(s): Ikawa-Yoshida A, Yoshii K, Kariwa H
  • Journal Title: Microbiol Immunol Volume: 55 Pages: 100-107
  • Peer Reviewed
• [Journal Article] Seroprevalence of West Nile Virus in Wild Birds in Far Eastern Russia Using a Focus Reduction Neutralization Test. (2011)
  • Author(s): Murata R, Yoshii K, Kariwa H
  • Journal Title: Am J Trop Med Hyg Volume: 84 Pages: 461-465
  • Peer Reviewed
• [Journal Article] Puumala virus infection in Syrian hamsters (Mesocricetus auratus)resembling hantavirus infection in natural rodent hosts (2011)
  • Author(s): Sanada T, Kariwa H, Yoshimatsu K, Arikawa J, Yoshii K
  • Journal Title: Virus Res Volume: 160 Pages: 108-119
  • NAID: 120003464630
  • Peer Reviewed
• [Journal Article] Construction of a replicon and an infectious cDNA clone of the Sofjin strain of the Far-Eastern subtype of tick-borne encephalitis virus (2011)
  • Author(s): Takano A, Yoshii K, Kariwa H
  • Journal Title: Arch Virol Volume: 156 Pages: 1931-1941
  • NAID: 120004856987
  • Peer Reviewed
• [Journal Article] Glycosylation of the Envelope Protein of West Nile Virus Affects Its Replication in Chicks (2011)
  • Author(s): Totani M, Yoshii K, Kariwa H and Takashima I
  • Journal Title: Avian Diseases Volume: 55 Pages: 561-568
  • Peer Reviewed
• [Journal Article] Needle-free jet injection of DNA and protein vaccine of the Far-Eastern subtype of Tick-borne encephalitis virus induced protective immunity in mice (2011)
  • Author(s): Omori-Urabe Y, Yoshii K, Kariwa H
  • Journal Title: Microbiol Immunol Volume: 55 Pages: 893-897
  • NAID: 10031121547
  • Peer Reviewed
• [Journal Article] ダニ媒介性脳炎 (2011)
  • Author(s): 苅和宏明、好井健太朗、高島郁夫
  • Journal Title: 公衆衛生 Volume: 75 Pages: 36-38
  • NAID: 10007312241
• [Journal Article] 日本国内におけるダニ媒介性脳炎の血清疫学調査 (2011)
  • Author(s): 好井健太朗、持舘景太、 苅和宏明、高島郁夫
  • Journal Title: 獣医畜産新報 Volume: 64 Pages: 801-803
• [Journal Article] Epizootiological study of tick-borne encephalitis virus infection in Japan (2011)
  • Author(s): Yoshii K, et al.
  • Journal Title: J Vet Med Sci Volume: 73 Pages: 409-12
  • NAID: 130000444345
  • Peer Reviewed
• [Journal Article] An efficient in vivo method for the isolation of Puumala virus in Syrian hamsters and the characterization of the isolates from Russia (2011)
  • Author(s): Seto T, et al.
  • Journal Title: J Virol Methods Volume: 173 Pages: 17-23
  • Peer Reviewed
• [Journal Article] Development of an ELISA system for tick-borne encephalitis virus infection in rodents (2011)
  • Author(s): Ikawa-Yoshida A, et al.
  • Journal Title: Microbiol Immunol Volume: 55 Issue: 2 Pages: 100-7
  • DOI: 10.1111/j.1348-0421.2010.00296.x
  • Peer Reviewed
• [Journal Article] Seroprevalence of West Nile virus in wild birds in far eastern Russia using a focus reduction neutralization test (2011)
  • Author(s): Murata R, et al.
  • Journal Title: Am J Trop Med Hyg Volume: 84 Pages: 461-5
  • Peer Reviewed
• [Journal Article] Continuity and change of Japanese encephalitis virus in Toyama Prefecture, Japan (2011)
  • Author(s): Obara M, et al.
  • Journal Title: Am J Trop Med Hyg Volume: 84 Pages: 695-708
  • Peer Reviewed
• [Journal Article] Puumala virus infection in Syrian hamsters (Mesocricetus auratus) resembling hantavirus infection in natural rodent hosts (2011)
  • Author(s): Sanada T, et al.
  • Journal Title: Virus Res Volume: 160 Pages: 108-19
  • Peer Reviewed
• [Journal Article] Construction of a replicon and an infectious cDNA clone of the Sofjin strain of the Far-Eastern subtype of tick-borne encephalitis virus (2011)
  • Author(s): Takano A, et al.
  • Journal Title: Arch Virol Volume: 156 Pages: 1931-41
  • Peer Reviewed
• [Journal Article] A conserved region in the prM protein is a critical determinant in the assembly of flavivirus particles (2011)
  • Author(s): Yoshii K, et al.
  • Journal Title: J Gen Virol Volume: 93 Pages: 27-38
  • Peer Reviewed
• [Journal Article] Needle-free jet injection of DNA and protein vaccine of the far-eastern subtype of tick-borne encephalitis virus induces protective immunity in mice (2011)
  • Author(s): Omori-Urabe Y, et al.
  • Journal Title: Microbiol Immunol Volume: 55 Issue: 12 Pages: 893-7
  • DOI: 10.1111/j.1348-0421.2011.00389.x
  • Peer Reviewed
• [Journal Article] Glycosylation of the envelope protein of West Nile Virus affects its replication in chicks (2011)
  • Author(s): Totani M, et al.
  • Journal Title: Avian Dis Volume: 55 Pages: 561-8
  • Peer Reviewed
• [Journal Article] Development of an ELISA system for tick-borne encephalitis virus infection in rodents (2011)
  • Author(s): Ikawa-Yoshida A
  • Journal Title: Microbiol Immunol Volume: 55 Pages: 100-107
  • Peer Reviewed
• [Journal Article] eroprevalence of West Nile Virus in Wild Birds in Far Eastern Russia Using a Focus Reduction Neutralization Test (2011)
  • Author(s): Murata R
  • Journal Title: Am J Trop Med Hyg Volume: 84 Pages: 17-23
  • Peer Reviewed
• [Journal Article] Glycosylation of the West Nile Virus envelope protein increases in vivo and in vitro viral multiplication in birds (2010)
  • Author(s): Murata R, Yoshii K, Kariwa H
  • Journal Title: Am J Trop Med Hyg Volume: 82 Pages: 696-704
  • Peer Reviewed
• [Journal Article] ダニ媒介性脳炎 (2010)
  • Author(s): 好井健太朗、苅和宏明、高島郁
  • Journal Title: 北海道獣医師会雑誌4 Volume: 54 Pages: 2-7
  • NAID: 10007312241
• [Journal Article] ウエストナイルウイルスの鳥類における増 殖性と極東ロシアでの抗体調査 (2010)
  • Author(s): 村田亮、好井健太朗、苅和宏明、高島郁夫
  • Journal Title: 獣医畜産新報 Volume: 63 Pages: 208-209
• [Journal Article] Different cross-reactivity of human and rodent sera to Tula virus and Puumala virus (2010)
  • Author(s): Tegshduuren E
  • Journal Title: Comp Immunol Microbiol Infect Dis Volume: 33
  • Peer Reviewed
• [Journal Article] Production of specific antibodies against SARS-coronavirus nucleocapsid protein without cross reactivity with human coronaviruses 229E and 0C43. (2010)
  • Author(s): Lee HK
  • Journal Title: J Vet Sci Volume: 11 Pages: 165-167
  • Peer Reviewed
• [Journal Article] Epidemiological study of hantavirus infection in the Samara Region ofEuropean Russia (2009)
  • Author(s): Kariwa H, Yoshii K, Yoshimatsu K, Arikawa J
  • Journal Title: J Vet Med Sci Volume: 71 Pages: 1569-1578
  • Peer Reviewed
• [Journal Article] Establishment of a neutralization test involving reporter gene-expressing virus-like particles of tick-borne encephalitis virus (2009)
  • Author(s): Yoshii K, Kariwa H, Takashima I
  • Journal Title: J. Virol. Methods. Volume: 161 Pages: 173-176
  • NAID: 120001498365
  • Peer Reviewed
• [Journal Article] Epidemiological study of hantavirus infection in the Samara Region of European Russia. (2009)
  • Author(s): Kariwa H, Tkachenko EA, Morozov VG, Seto T, Tanikawa Y, Kolominov SI, Belov SN, Nakamura I, Hashimoto N, Balakiev AE, Dzagurnova TK, Abu Daud NH, Miyashita D, Medvedkina OA, Nakauchi M, Ishizuka M, Yoshii K, Yoshimatsu K, Arikawa J, Takashima I
  • Journal Title: Journal of Veterinary Medical Science. 71 Pages: 1569-1578
  • NAID: 130000149982
  • Peer Reviewed
• [Journal Article] Establishment of a neutralization test involving reporter gene-expressing virus-like particles of tick-borne encephalitis virus. (2009)
  • Author(s): Yoshii K, Ikawa A, Chiba Y, Omori Y, Maeda J, Murata R, Kariwa H, Takashima I.
  • Journal Title: Journal of Virological Methods 161 Pages: 173-176
  • NAID: 120001498365
  • Peer Reviewed
• [Journal Article] A PCR-based protocol for the generation of a recombinant West Nile virus. (2009)
  • Author(s): Maeda A, Murata R, Akiyama M, Takashima I, Kariwa H, Watanabe T, Kurane I, Maeda J.
  • Journal Title: Virus Research 144 Pages: 35-43
  • Peer Reviewed
• [Presentation] ダニ媒介性フラビウイルスの病態発現機序 (2012)
  • Author(s): 好井健太朗
  • Organizer: 第60回日本ウイルス学会学術集会
  • Place of Presentation: グランキューブ 大阪(大阪)
  • Year and Date: 2012-11-13
• [Presentation] ダニ媒介性フラビウイルスによる中枢神経系障害に関わるウイルス因子の同定 (2012)
  • Author(s): 好井健太朗ら
  • Organizer: 第154回日本獣医学会学術集会
  • Place of Presentation: 岩手大学(盛岡)
  • Year and Date: 2012-09-15
• [Presentation] Epidemiology of Hantavirus Infection in Russia and the Establishment of Animal Model for Hantavirus Infection (2012)
  • Author(s): Kariwa H, et al.
  • Organizer: Mini-symposium on Emerging and Re-emerging Viral Diseases in Asia
  • Place of Presentation: B-ConPlaza (Beppu)
  • Year and Date: 2012-06-20
• [Presentation] Critical Determinant of Neurologic Disease of Tick-borne Flaviviruses (2012)
  • Author(s): Yoshii K. et al.
  • Organizer: 46th Joint Working Conference on Viral Diseases, The Japan-United States Cooperative Medical Science Program
  • Place of Presentation: B-ConPlaza (Beppu)
  • Year and Date: 2012-06-20
• [Presentation] Isolation and characterization of hantaviruses from wild rodents and epidemiology of hemorrhagic fever with renal syndrome in Russia (2012)
  • Author(s): Kariwa H, et al.
  • Organizer: THE 9th JAPAN-CHINA INTERNATIONAL CONFERENCE OF VIROLOGY
  • Place of Presentation: Hokkaido University(Sapporo)
  • Year and Date: 2012-06-13
• [Presentation] リバースジェネティクスを用いた極東型ダニ媒介性脳炎ウイルスの病原性決定因子の解析 (2012)
  • Author(s): 境瑞紀
  • Organizer: 第47回日本脳炎ウイルス生態学研究会
  • Place of Presentation: 阿蘇リゾートグランヴィリオホテル（阿蘇市）
• [Presentation] 2008年北海道におけるダニ媒介性脳炎ウイルスの分離と性状解析 (2012)
  • Author(s): 好井健太朗
  • Organizer: 第47回日本脳炎ウイルス生態学研究会
  • Place of Presentation: 阿蘇リゾートグランヴィリオホテル（阿蘇市）
• [Presentation] Isolation and characterization of hantaviruses from wild rodents and epidemiology of hemorrhagic fever with renal syndrome in Russia (2012)
  • Author(s): Kariwa H
  • Organizer: The 9th Japan-China International Conference of Virology
  • Place of Presentation: 北海道大学（札幌市）
• [Presentation] Critical Determinant of Neurologic Disease of Tick-borne Flaviviruses (2012)
  • Author(s): Yoshii K
  • Organizer: 46th Joint Working Conference on Viral Diseases, The Japan-United States Cooperative Medical Science Program
  • Place of Presentation: ビーコンプラザ（別府市）
  • Invited
• [Presentation] Epidemiology of Hantavirus Infection in Russia and the Establishment of Animal Model for Hantavirus Infection (2012)
  • Author(s): Kariwa H
  • Organizer: 46th Joint Working Conference on Viral Diseases, The Japan-United States Cooperative Medical Science Program
  • Place of Presentation: ビーコンプラザ（別府市）
  • Invited
• [Presentation] ダニ媒介性フラビウイルスによる中枢神経系障害に関わるウイルス因子の同定 (2012)
  • Author(s): 好井健太朗
  • Organizer: 第154回日本獣医学会学術集会
  • Place of Presentation: 岩手大学（盛岡市）
• [Presentation] 極東型ダニ媒介性脳炎ウイルスの強毒化に関わるウイルス側因子の特定 (2012)
  • Author(s): 境瑞紀
  • Organizer: 第154回日本獣医学会学術集会
  • Place of Presentation: 岩手大学（盛岡市）
• [Presentation] ダニ媒介性フラビウイルスのインターフェロンアンタゴニスト作用の解析 (2012)
  • Author(s): 鶴田征太郎
  • Organizer: 154回日本獣医学会学術集会
  • Place of Presentation: 岩手大学（盛岡市）
• [Presentation] エゾヤチネズミの腎臓由来細胞株（MRK101細胞）におけるインターフェロン応答の解析 (2012)
  • Author(s): 中尾桃子
  • Organizer: 第154回日本獣医学会学術集会
  • Place of Presentation: 岩手大学（盛岡市）
• [Presentation] 新たに分離されたHokkaidoウイルスの性状解析 (2012)
  • Author(s): 真田崇弘
  • Organizer: 第154回日本獣医学会学術集会
  • Place of Presentation: 岩手大学（盛岡市）
• [Presentation] ダニ媒介性フラビウイルスの病態発現機序 (2012)
  • Author(s): 好井健太朗
  • Organizer: 第60回日本ウイルス学会学術集会
  • Place of Presentation: グランキューブ大阪（大阪市）
  • Invited
• [Presentation] 極東型ダニ媒介性脳炎ウイルスの強毒化に関わるウイルス側因子の特定 (2012)
  • Author(s): 境瑞紀
  • Organizer: 第60回日本ウイルス学会学術集会
  • Place of Presentation: グランキューブ大阪（大阪市）
• [Presentation] ダニ媒介性フラビウイルスのインターフェロンアンタゴニスト作用の解析 (2012)
  • Author(s): 鶴田征太郎
  • Organizer: 第60回日本ウイルス学会学術集会
  • Place of Presentation: グランキューブ大阪（大阪市）
• [Presentation] Evaluation of antigenic cross-reactivity of tick-borne encephalitis virus and Omsk hemorrhagic fever virus (2012)
  • Author(s): Chidumayo Nozyechi
  • Organizer: 第60回日本ウイルス学会学術集会
  • Place of Presentation: グランキューブ大阪（大阪市）
• [Presentation] エゾヤチネズミの腎臓由来細胞株（MRK101細胞）におけるインターフェロン応答の解析 (2012)
  • Author(s): 中尾桃子
  • Organizer: 第60回日本ウイルス学会学術集会
  • Place of Presentation: グランキューブ大阪（大阪市）
• [Presentation] 新たに分離されたHokkaidoウイルスの性状解析 (2012)
  • Author(s): 真田崇弘
  • Organizer: 第60回日本ウイルス学会学術集会
  • Place of Presentation: グランキューブ大阪（大阪市）
• [Presentation] The N-terminus of the Montano hantavirus nucleocapsid protein possesses broadly cross-reactive conformation-dependent epitopes (2012)
  • Author(s): Ngonda Saasa
  • Organizer: 第60回日本ウイルス学会学術集会
  • Place of Presentation: グランキューブ大阪（大阪市）
• [Presentation] 野生マウス由来 Oas 遺伝子座導入コンジェニックマウスにおけるダニ媒介性脳炎ウイルスの神経病原性の解 析 (2011)
  • Author(s): 好井健太朗ら
  • Organizer: 第152回日本獣医学会
  • Place of Presentation: 大阪府立大学(堺)
  • Year and Date: 2011-09-19
• [Presentation] Isolation and characterization of hantaviruses from wild rodents and epidemiology of hemorrhagic fever with renal syndrome in Russia (2011)
  • Author(s): Kariwa H, et al.
  • Organizer: International Union of Microbiological Societies 2011 Congress
  • Place of Presentation: Sapporo Convention Center(Sapporo)
  • Year and Date: 2011-09-15
• [Presentation] Construction and characterization of chimeric virus between tick-borne encephalitis virus and Omsk hemorrhagic fever virus (2011)
  • Author(s): Yoshii K, et al.
  • Organizer: International Union of Microbiological Societies 2011 Congress
  • Place of Presentation: Sapporo Convention Center (Sapporo)
  • Year and Date: 2011-09-15
• [Presentation] ダニ媒介性脳炎/オムスク出血熱のキメラウイルスを用いた病態発現機序の解析 (2011)
  • Author(s): 好井健太朗, ら
  • Organizer: 第15回日本神経ウイルス研究会
  • Place of Presentation: 金沢白鳥路ホテル(金沢市)
• [Presentation] 野生マウス由来Oas遺伝子座導入コンジェニックマウスの作製とフラビウイルス抵抗性の解析 (2011)
  • Author(s): 好井健太朗, ら
  • Organizer: 第46回日本脳炎ウイルス生態学研究会
  • Place of Presentation: 金沢白鳥路ホテル(金沢市)
• [Presentation] Construction and characterization of chimeric virus between tick-borne encephalitis virus and Omsk hemorrhagic fever virus (2011)
  • Author(s): Yoshii K, et al.
  • Organizer: International Union of Microbiological Societies 2011 Congress
  • Place of Presentation: 札幌コンベンションセンター(札幌市)
• [Presentation] Isolation and characterization of Tick-borne encephalitis virus in Hokkaido, Japan in 2008 (2011)
  • Author(s): Yamazaki S, et al.
  • Organizer: International Union of Microbiological Societies 2011 Congress
  • Place of Presentation: 札幌コンベンションセンター(札幌市)
• [Presentation] Role of the N-linked glycan of envelope protein of tick-borne encephalitis in the virus replication and pathogenicity (2011)
  • Author(s): Yanagihara N, et al.
  • Organizer: International Union of Microbiological Societies 2011 Congress
  • Place of Presentation: 札幌コンベンションセンター(札幌市)
• [Presentation] Development of the lethal animal model of human hantavirus infection (2011)
  • Author(s): Seto T, et al.
  • Organizer: International Union of Microbiological Societies 2011 Congress
  • Place of Presentation: 札幌コンベンションセンター(札幌市)
• [Presentation] Susceptibility of cultured cells derived from the kidney of gray red backed vole (Myodes rufocanus) to Puumala virus and other hantaviruses (2011)
  • Author(s): Sanada T, et al.
  • Organizer: International Union of Microbiological Societies 2011 Congress
  • Place of Presentation: 札幌コンベンションセンター(札幌市)
• [Presentation] Epizootiological investigation of hantavirus infection in Japan and genetic variation of Hokkaido virus in Myodes rufocanus (2011)
  • Author(s): Ozaki Y, et al.
  • Organizer: International Union of Microbiological Societies 2011 Congress
  • Place of Presentation: 札幌コンベンションセンター(札幌市)
• [Presentation] The identification of the rodent reservoir of Montano virus, a novel hantavirus in Mexico (2011)
  • Author(s): Saasa N, et al.
  • Organizer: International Union of Microbiological Societies 2011 Congress
  • Place of Presentation: 札幌コンベンションセンター(札幌市)
• [Presentation] Characterization of hantaviruses from wild rodents and epidemiology of hemorrhagic fever with renal syndrome in Russia (2011)
  • Author(s): Kariwa H, et al.
  • Organizer: International Union of Microbiological Societies 2011 Congress
  • Place of Presentation: 札幌コンベンションセンター(札幌市)
• [Presentation] 2008年北海道で分離されたダニ媒介性脳炎ウイルスOshima 08-AS株の病原性解析 (2011)
  • Author(s): 山崎翔子, ら
  • Organizer: 第152回日本獣医学会
  • Place of Presentation: 大阪府立大学(堺市)
• [Presentation] 野生マウス由来Oas遺伝子座導入コンジェニックマウスにおけるダニ媒介性脳炎ウイルスの神経病原性の解析 (2011)
  • Author(s): 好井健太朗, ら
  • Organizer: 第152回日本獣医学会
  • Place of Presentation: 大阪府立大学(堺市)
• [Presentation] ダニ媒介性脳炎ウイルスのE蛋白糖鎖は哺乳動物細胞におけるウイルス粒子分泌に影響する (2011)
  • Author(s): 柳原なつみ, ら
  • Organizer: 第152回日本獣医学会
  • Place of Presentation: 大阪府立大学(堺市)
• [Presentation] 日本のげっ歯類のハンタウイルス感染状況に関する血清疫学調査とエゾヤチネズミが保有するHokkaidoウイルスの遺伝的多様性 (2011)
  • Author(s): 尾崎由佳, ら
  • Organizer: 第152回日本獣医学会
  • Place of Presentation: 大阪府立大学(堺市)
• [Presentation] エゾヤチネズミ(Myodes rufocanus)の腎臓由来細胞系の確立とHokkaidoウイルス分離への応用 (2011)
  • Author(s): 真田崇弘, ら
  • Organizer: 第152回日本獣医学会
  • Place of Presentation: 大阪府立大学(堺市)
• [Presentation] 新規相同組換え技術による組換えダニ媒介性脳炎ウイルスの構築 (2011)
  • Author(s): 川岸崇裕, ら
  • Organizer: 第152回日本獣医学会
  • Place of Presentation: 大阪府立大学(堺市)
• [Presentation] 2008年北海道におけるダニ媒介性脳炎ウイルスの分離と性状解析 (2011)
  • Author(s): 好井健太朗, ら
  • Organizer: 第11回人と動物の共通感染症研究会学術集会
  • Place of Presentation: 国立感染症研究所(東京都)
• [Presentation] リバースジェネティクスを用いた極東型ダニ媒介性脳炎ウイルスの病原性決定因子の解析 (2011)
  • Author(s): 境瑞紀, ら
  • Organizer: 第18回トガ・フラビ・ペスチウイルス研究会
  • Place of Presentation: 国立感染症研究所(東京都)
• [Presentation] ハンタウイルス感染症の疫学-日本とロシアにおけるハンタウイルス感染症の比較疫学的研究- (2011)
  • Author(s): 苅和宏明
  • Organizer: 第11回日本バイオセーフティ学会
  • Place of Presentation: 文部科学省研究交流センター(つくば市)(招待講演)
• [Presentation] ダニ媒介性脳炎/オムスク出血熱のキメラウイルスの作 成と性状解析 (2010)
  • Author(s): 好井健太朗、寸田祐嗣、 苅和宏明、MichaelR. Holbrook、高島郁夫
  • Organizer: 第58回日本ウイルス学会学術集会
  • Place of Presentation: 阿波銀ホール(徳島)
  • Year and Date: 2010-11-07
• [Presentation] Puumalaウイルスを感染させたシリアンハムスター(Mesocricetus auratus)の感染動態の解析 (2010)
  • Author(s): 真田崇弘
  • Organizer: 第58回日本ウイルス学会学術集会
  • Place of Presentation: あわぎんホール(徳島)
  • Year and Date: 2010-11-07
• [Presentation] メキシコの野生げっ歯類が保有するハンタウイルスの抗原性解析 (2010)
  • Author(s): 吉田喜香
  • Organizer: 第58回日本ウイルス学会学術集会
  • Place of Presentation: あわぎんホール(徳島)
  • Year and Date: 2010-11-07
• [Presentation] ダニ媒介性脳炎ウイルスSofjin株の感染性cDNAの構築 (2010)
  • Author(s): 高野絢子
  • Organizer: 第58回日本ウイルス学会学術集会
  • Place of Presentation: あわぎんホール(徳島)
  • Year and Date: 2010-11-07
• [Presentation] ダニ媒介性脳炎/オムスク出血熱のキメラウイルスの作成と性状解析 (2010)
  • Author(s): 好井健太朗
  • Organizer: 第58回日本ウイルス学会学術集会
  • Place of Presentation: あわぎんホール(徳島)
  • Year and Date: 2010-11-07
• [Presentation] ウエストナイルウイルスのE蛋白糖鎖付加が鳥類における病原性に与える影響の解析 (2010)
  • Author(s): 戸谷理詩
  • Organizer: 第58回日本ウイルス学会学術集会
  • Place of Presentation: あわぎんホール(徳島)
  • Year and Date: 2010-11-07
• [Presentation] 日本国内におけるダニ媒介性脳炎の血清疫学調査 (2010)
  • Author(s): 好井健太朗
  • Organizer: 第10回人と動物の共通感染症研究会学術集会
  • Place of Presentation: 日本大学会館(東京)
  • Year and Date: 2010-10-30
• [Presentation] ダニ媒介性脳炎/オムスク出血熱のキメラウイルスの作成と性状解析 (2010)
  • Author(s): 好井健太朗ら
  • Organizer: 第150回日本獣医学会
  • Place of Presentation: 帯広畜産大学(帯広)
  • Year and Date: 2010-09-16
• [Presentation] 2008年北海道におけるダニ媒介性脳炎ウイルスの分離と性状解析 (2010)
  • Author(s): 山崎翔子
  • Organizer: 第150回日本獣医学会
  • Place of Presentation: 帯広畜産大学(北海道)
  • Year and Date: 2010-09-16
• [Presentation] ダニ媒介性脳炎ウイルスのE蛋白の糖鎖付加がウイルス性状に与える影響 (2010)
  • Author(s): 柳原なつみ
  • Organizer: 第150回日本獣医学会
  • Place of Presentation: 帯広畜産大学(北海道)
  • Year and Date: 2010-09-16
• [Presentation] ダニ媒介性脳炎ウイルスSofjin株の感染性cDNAの構築 (2010)
  • Author(s): 高野絢子
  • Organizer: 第150回日本獣医学会
  • Place of Presentation: 帯広畜産大学(北海道)
  • Year and Date: 2010-09-16
• [Presentation] ダニ媒介性脳炎/オムスク出血熱のキメラウイルスの作成と性状解析 (2010)
  • Author(s): 好井健太朗
  • Organizer: 第150回日本獣医学会
  • Place of Presentation: 帯広畜産大学(北海道)
  • Year and Date: 2010-09-16
• [Presentation] メキシコ由来のハンタウイルスに対するモノクローナル抗体の作出と各種ハンタウイルスに対する反応性の検討 (2010)
  • Author(s): 吉田喜香
  • Organizer: 第150回日本獣医学会
  • Place of Presentation: 帯広畜産大学(北海道)
  • Year and Date: 2010-09-16
• [Presentation] ウエストナイルウイルスのE蛋白糖鎖付加が鳥類における病態に与える影響の解析 (2010)
  • Author(s): 戸谷理詩
  • Organizer: 第150回日本獣医学会
  • Place of Presentation: 帯広畜産大学(北海道)
  • Year and Date: 2010-09-16
• [Presentation] Puumalaウイルスを感染させたシリアンハムスター(Mesocricetus auratus)の感染動態の解析 (2010)
  • Author(s): 真田崇弘
  • Organizer: 第150回日本獣医学会
  • Place of Presentation: 帯広畜産大学(北海道)
  • Year and Date: 2010-09-16
• [Presentation] Isolation of Amur and Hantaan viruses from wild rodents and the epidemiology of hemorrhagic fever with renal syndrome in Far East Russia (2010)
  • Author(s): Kariwa H, et al.
  • Organizer: U.S.-Japan Cooperative Medical Science Program 44th Joint Working Conference on Viral Diseases
  • Place of Presentation: Hokkaido University (Sapporo)
  • Year and Date: 2010-06-29
• [Presentation] solation of Amur and Hantaan viruses from wild rodents and the epidemiology of hemorrhagic fever with renal syndrome in Far East Russia (2010)
  • Author(s): Kariwa H
  • Organizer: U.S.-Japan Cooperative Medical Science Program 44^<th> Joint Working Conference on Viral Diseases
  • Place of Presentation: 北海道大学(北海道) 招待講演
  • Year and Date: 2010-06-29
• [Presentation] ダニ媒介性脳炎/オムスク出血熱のキメラウイルスの作成と性状解析 (2010)
  • Author(s): 好井健太朗
  • Organizer: 第45回日本脳炎ウイルス生態学研究会
  • Place of Presentation: 国立感染症研究所(東京)
  • Year and Date: 2010-05-28
• [Presentation] Isolation of Amur and Hantaan viruses from wild rodents and the epidemiology of hemorrhagic feverwith renal syndrome in Far East Russia (2010)
  • Author(s): Kariwa H, et al.
  • Organizer: VIII International Conference on HFRS, HPS and Hantaviruses
  • Place of Presentation: Divani Palace Acropolis, Athens (Greece)
  • Year and Date: 2010-05-21
• [Presentation] Isolation of Amur and Hantaan viruses from wild rodents and the epidemiology of hemorrhagic fever with renal syndrome in Far E ast Russia (2010)
  • Author(s): Kariwa H
  • Organizer: VIII International Conference on HFRS, HPS and Hantaviruses. Athens
  • Place of Presentation: Athens (Greek)
  • Year and Date: 2010-05-21
• [Presentation] Development of diagnostic methods applicable to various hantavi rus infections (2010)
  • Author(s): Sanada T
  • Organizer: VIII International Conference on HFRS, HPS and Hantaviruses
  • Place of Presentation: Athens (Greek)
  • Year and Date: 2010-05-21
• [Presentation] ダニ媒介性脳炎ウイルスSofjin株のレプリコンの構築 (2009)
  • Author(s): 高野絢子、大森優紀、好井健太朗、石塚万理子、村田亮、苅和宏明、高島郁夫
  • Organizer: 第57回日本ウイルス学会学術集会
  • Place of Presentation: 都市センターホテル(東京)
  • Year and Date: 2009-10-27
• [Presentation] 極東ロシアの野鼠からのハンタウイルスの分離と人におけるウイルス感染状況の調査 (2009)
  • Author(s): 吉川佳佑、苅和宏明、瀬戸隆弘、真田崇弘、好井健太朗、吉松組子、有川二郎、高島郁夫
  • Organizer: 第57回日本ウイルス学会学術集会
  • Place of Presentation: 都市センターホテル(東京)
  • Year and Date: 2009-10-27
• [Presentation] メキシコの野生げっ歯類が保有するハンタウイルスの遺伝子解析 (2009)
  • Author(s): 吉田喜香、苅和宏明、Ramos Celso, Hernandez Cornelio S.Almaraz, Maria L.R., 高野絢子、戸谷理詩、宮下大輔、Ngonda Saasa、瀬戸隆弘、真田崇弘、吉川佳佑、好井健太朗、吉松組子、有川二郎、高島郁夫
  • Organizer: 第57回日本ウイルス学会学術集会
  • Place of Presentation: 都市センターホテル(東京)
  • Year and Date: 2009-10-27
• [Presentation] オムスク出血熱ウイルスの感染性cDNAの構築 (2009)
  • Author(s): 好井健太朗ら
  • Organizer: 第57回日本ウイルス学会学術集会
  • Place of Presentation: 都市センターホテル(東京)
  • Year and Date: 2009-10-26
• [Presentation] 極東ロシアの野鳥におけるウエストナイル熱の血清疫学調査と中和試験の評価 (2009)
  • Author(s): 村田亮、好井健太朗、苅和宏明、高島郁夫
  • Organizer: 第57回日本ウイルス学会学術集会
  • Place of Presentation: 都市センターホテル(東京)
  • Year and Date: 2009-10-26
• [Presentation] 日本国内におけるダニ媒介性脳炎の血清疫学調査 (2009)
  • Author(s): 持舘景太、好井健太朗、大森優紀、千葉裕美子、村田亮、真田崇弘、前田潤子、苅和宏明、高島郁夫
  • Organizer: 第57回日本ウイルス学会学術集会
  • Place of Presentation: 都市センターホテル(東京)
  • Year and Date: 2009-10-26
• [Presentation] オムスク出血熱ウイルスの感染性cDNAの構築 (2009)
  • Author(s): 好井健太朗ら
  • Organizer: 148回日本獣医学会学術集会
  • Place of Presentation: とりぎん文化会館(鳥取)
  • Year and Date: 2009-09-27
• [Presentation] 極東ロシアの野鳥におけるウエストナイル熱の血清疫学調査と中和試験の評価 (2009)
  • Author(s): 村田亮、橋口和明、好井健太朗、野田寛、伊川綾恵、原田祐里、苅和宏明、高島郁夫
  • Organizer: 第148回日本獣医学会学術集会
  • Place of Presentation: とりぎん文化会館(鳥取)
  • Year and Date: 2009-09-27
• [Presentation] 日本国内におけるダニ媒介性脳炎の血清疫学調査 (2009)
  • Author(s): 持舘景太、好井健太朗、大森優紀、千葉裕美子、村田亮、真田崇弘、前田潤子、苅和宏明、高島郁夫
  • Organizer: 第148回日本獣医学会学術集会
  • Place of Presentation: とりぎん文化会館(鳥取)
  • Year and Date: 2009-09-27
• [Presentation] ダニ媒介性脳炎ウイルスSofjin株のレプリコンの構築 (2009)
  • Author(s): 高野絢子、大森優紀、好井健太朗、石塚万理子、村田亮、苅和宏明、高島郁夫
  • Organizer: 第148回日本獣医学会学術集会
  • Place of Presentation: とりぎん文化会館(鳥取)
  • Year and Date: 2009-09-27
• [Presentation] オムスク出血熱ウイルスの感染性cDNAの構築 (2009)
  • Author(s): 好井健太朗、苅和宏明、高島郁夫、Holbrook Micae
  • Organizer: 第148回日本獣医学会学術集会
  • Place of Presentation: とりぎん文化会館(鳥取)
  • Year and Date: 2009-09-27
• [Presentation] メキシコの野生げっ歯類が保有するハンタウイルスの遺伝子解析 (2009)
  • Author(s): 吉田喜香、苅和宏明、高野絢子、戸谷理詩、宮下大輔、Saasa Ngonda、瀬戸隆弘、真田崇弘、吉川佳佑、好井健太朗、吉松組子、有川二郎、高島郁夫
  • Organizer: 第148回日本獣医学会学術集会
  • Place of Presentation: とりぎん文化会館(鳥取)
  • Year and Date: 2009-09-27
• [Presentation] Development of diagnostic methods applicable to various serotypes of hantavirus infections. (2009)
  • Author(s): Kariwa H, Sanada T, Seto T, Yoichi Tanikawa, Kentaro Yoshii, Kumiko Yoshimatsu, Jiro Arikawa, Ikuo Takashima
  • Organizer: 43^<rd> Joint Working Conference on Viral Diseases, US-Japan Cooperative medical Science Program
  • Place of Presentation: Wistar Auditorium, Philadelphia, PA, USA
  • Year and Date: 2009-07-22
• [Presentation] Development of diagnostic methods applicable to various serotypes of hanatavorus infections (2009)
  • Author(s): Kariwa H, et al.
  • Organizer: 43rd Joint Working Conference on Viral Diseases, US-Japan Cooperative medical Science Program
  • Place of Presentation: Wistar Institute, Philadelphia, (Pennsylvania, USA)
  • Year and Date: 2009-07-21
• [Presentation] ハンタウイルス感染症の疫学 (2009)
  • Author(s): 苅和宏明
  • Organizer: 日本臨床ウイルス学会
  • Place of Presentation: 高知市文化プラザかるぽーと(高知)
  • Year and Date: 2009-06-14
• [Presentation] 極東ロシアのげっ歯類からのハンタウイルスの分離とウイルス遺伝子の性状解析 (2009)
  • Author(s): 吉川佳佑、苅和宏明、瀬戸隆弘、真田崇弘、石塚万里子、吉松組子、有川二郎、Lenid Ivanov、好井健太朗、高島郁夫
  • Organizer: 第147回日本獣医学会学術集会
  • Place of Presentation: 栃木県総合文化センター(宇都宮)
  • Year and Date: 2009-04-03
• [Book] In Animal Viruses edited by A. Maeda,Transworld Research Network, Karela, India (2010)
  • Author(s): Kariwa H, Yoshii K, Yoshimatsu K, Arikawa J
  • Publisher: Epidemiology of hantavirus infection: Hokkaido virus and its mode of infection among the gray red-backed vole, Myodes rufocanus
• [Book] In Animal Viruses edited by Maeda A. Transworld Research Network, Karela, India (2010)
  • Author(s): Takashima I, Kariwa H, and Shirato K.
  • Publisher: West Nile fever
• [Book] In Animal Viruses edited by Maeda A. Transworld Research Network, Karela, India (2010)
  • Author(s): Yoshii K, Kariwa H, and Takashima I
  • Publisher: Tick-borne encephalitis.
• [Book] Animal Viruses (2010)
  • Author(s): Kariwa H(共著)
  • Publisher: Transworld Research Network, Kerala (India)
• [Book] Animal Viruses (2010)
  • Author(s): Yoshii K(共著)
  • Publisher: Transworld Research Network, Kerala (India)
• [Book] 獣医公衆衛生学実習 (2010)
  • Author(s): 苅和宏明(共著)
  • Publisher: 学窓社