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Development of surveillance tools for eradication of schistosomiasis japonica applicable for the endemic areas in China

Research Project

Project/Area Number 21406008
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Parasitology (including Sanitary zoology)
Research InstitutionTokyo Medical and Dental University

Principal Investigator

OHTA Nobuo  東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (10143611)

Co-Investigator(Kenkyū-buntansha) 二瓶 直子  国立感染症研究所, 昆虫医科学部, 客員研究員 (70425677)
Co-Investigator(Renkei-kenkyūsha) NIHEI Naoko  国立感染症研究所, 国立感染症研究所・昆虫医科昆虫医科学部, 客員研究員 (70425677)
KUMAGAI Takashi  東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (40369054)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2011: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Keywords蠕虫 / 日本住血吸虫 / DNA診断 / LAMP / Oncomelania / 遺伝子診断 / LAMP法 / PCR法 / 疾病対策 / GPS / PCR
Research Abstract

New surveillance tools for schistosomiasis control were developed and tested in endemic foci in China. LAMP method was confirmed to be an easy method of high sensitivity and specificity, which could be applied for on-site use without special equipments. Together with those simple and reliable tools, epidemiological surveillance using GIS for evaluating risk factors of bleeding snail hosts should be introduced especially for big endemic fields like those in China. By the use of those new tools, more effective strategy for eliminating schistosomiasis japonica was proposed for endemic foci in China.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (37 results)

All 2012 2011 2010 2009

All Journal Article (17 results) (of which Peer Reviewed: 15 results) Presentation (16 results) Book (3 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Interleukin-4(IL-4) and IL-13 suppress excessive neutrophil infiltration and hepatocyte damage during acute murine schistosomiasis japonica2012

    • Author(s)
      Seki T, Kumagai T, Kwansa-Bentum B, Furushima-Shimogawara R, Anyan WK, Miyazawa Y, Iwakura Y, Ohta N
    • Journal Title

      Infect Immun

      Volume: 80 Pages: 159-68

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Loop-mediated isothermal amplification(LAMP): early detection of Toxoplasma gondii infection in mice2012

    • Author(s)
      Kong QM, Lu SH, Tong QB, Lou D, Chen R, Zheng B, Kumagai T, Wen LY, Ohta N, Zhou XN
    • Journal Title

      Parasit Vectors

      Volume: 5 Pages: 2-2

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Loop-mediated isothermal amplification (LAMP) : early detection of Toxoplasma gondii infection in mice2012

    • Author(s)
      Kong QM, Lu SH, Tong QB, Lou D, Chen R, Zheng B, Kumagai T, Wen LY, Ohta N, Zhou XN
    • Journal Title

      Parasites and Vectors

      Volume: 5 Issue: 1 Pages: 2-2

    • DOI

      10.1186/1756-3305-5-2

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-4 (IL-4) and IL-13 suppress excessive neutrophil infiltration and hepatocyte damage during acute murine schistosomiasis japonica2012

    • Author(s)
      T.Seki
    • Journal Title

      Infect Immun

      Volume: 80 Issue: 1 Pages: 159-168

    • DOI

      10.1128/iai.05581-11

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Schistosomicidal and anti-fecundity effects of oral treatment of synthetic endperoxide compound N-892011

    • Author(s)
      Taniguchi T, Kumagai T, Shimogawara R, Ichinose S, Hiramoto A, Sato A, Morita M, Nojima M, Kim HS, Wataya Y, Ohta N
    • Journal Title

      Parasitol Int

      Volume: 60 Pages: 231-6

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Using ALOS satellite images to develop efficient measures against vector-borne diseases-Regional differences in outbreak risk for schistosomiasis in China2011

    • Author(s)
      Nihei N, Komagata O, Kobayashi M, Ohta N, Saitoh Y, Mochizuki K, Chen R, Lu SH, Wen LY, Wang TP
    • Journal Title

      Proc. Int Congress for the 4^<th> ALOS PI Symposium

    • Related Report
      2011 Final Research Report
  • [Journal Article] Cerebral schistosomiasis due to Schistosoma haematobium confirmed by PCR analysis of brain specimen2011

    • Author(s)
      Imai K, Koibuchi T, Kumagai T, Maeda T, Osada Y, Ohta N, Koga M, Nakamura H, Miura T, Iwamoto A, Fujii T
    • Journal Title

      J Clin Microbiol

      Volume: 49 Pages: 3703-6

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Schistosomicidal and anti-fecundity effects of oral treatment of synthetic endoperoxide compound N-892011

    • Author(s)
      Taniguchi T, Kumagai T, Shimogawara R, Ichinose S, Hiramoto A, Sato A, Morita M, Nojima M, Kim HS, Wataya Y, Ohta N
    • Journal Title

      Parasitology International

      Volume: 60 Issue: 3 Pages: 231-236

    • DOI

      10.1016/j.parint.2011.02.007

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cerebral schistosomiasis due to Schistosoma haematobium confirmed by PCR analysis of brain specimen2011

    • Author(s)
      Imai K, Koibuchi T, Kumagai T, Maeda T, Osada Y, Ohta N, Koga M, Nakamura H, Miura T, Iwamoto A, Fujii T
    • Journal Title

      Journal of Clinical Microbiology

      Volume: 49 Issue: 10 Pages: 3703-6

    • DOI

      10.1128/jcm.01073-11

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detection of potential infections of Schistosoma japonicum in the intermediate host snail, Oncomelania hupensis, by PCR and loop-mediated isothermal amplification(LAMP) assay2010

    • Author(s)
      Kumagai T, Shimogawara R, Ohmae H, Wang TP, Lu SH, Chen R, Wen LY, Ohta N
    • Journal Title

      Am J Trop Med Hyg

      Volume: 83 Pages: 542-8

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Schistosome eggs have a direct role in the induction of basophils capable of a high level of IL-4 production : Comparative study of single-and bisexual infection of Schistosoma mansoni in vivo2010

    • Author(s)
      Anyan WK, Kumagai T, Shimogawara R, Seki T, Akao N, Obata K, Bentum BK, Bosompem BK, BoakyeDA, Wilson MD, Karasuyama H, Ohta N
    • Journal Title

      Trop Med Health

      Volume: 38 Pages: 1-12

    • NAID

      10026420055

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Detection of potential infections of Schistosoma/aponicum in the intermediate host snail, Oncomelania hupensis, by PCR and loop-mediated isotherural amplification(LAMP)assay2010

    • Author(s)
      Kumagai T, Shimogawara R, Ohmae H, Wang TP, Lu SH, Chen R, Wen LY, Ohta N
    • Journal Title

      American Journal of topical Medicine & Hygiene

      Volume: 83 Pages: 542-548

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Schistosomicidal and anti-fecundity effects of oral treatment of synthtic endperoxide compound N-89.2010

    • Author(s)
      Taniguchi T, Kumagai T, Shimogawara R, Ichinose S, Hiramoto A, Sato A, Morita M, Nojima M, Kim HS, Wataya Y, Ohta N.
    • Journal Title

      Parasitology International

      Volume: 60 印刷中

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Using ALOS satellite images to develop efficient measures against vector-borne diseases-Regional differences in outbreake risk for schistosomiasis in China.2010

    • Author(s)
      Nihei N, Komagata O, Kobayashi M, Ohta N, Saitoh Y, Mochizuki K, Chen R, Lu SH, Wen LY, Wang TP.
    • Journal Title

      Proceedings for the 4^<th>ALOS PI symposium

      Volume: 印刷中

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Detection of potential infections of Schistosoma japonicum in the intermediate host snail, Oncomelania hupensis, by PCR and loop-mediated isothermal amplification(LAMP)assay2010

    • Author(s)
      Kumagai T, Shimogawara R, Ohmae H, Wang TP, Lu SH, Chen R, Wen LY, Ohta N
    • Journal Title

      American Journal of Tropical Medicine & Hygiene (印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Schistosome eggs have a direct role in the induction of basophils capable of a high level of IL-4 production : Comparative study of single- and bisexual infection of Schistosoma mansoni in vivo2010

    • Author(s)
      Anyan WK, Kumagai T, Shimogawara R, Seki T, Akao N, Obata K, Bentum BK, Bosompem BK, Boakye DA, Wilson MD, Karasuyama H, Ohta N
    • Journal Title

      Tropical Medicine and Health 38

      Pages: 1-12

    • NAID

      10026420055

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spatial analysis and remote sensing for monitoring systems of Oncomelania nosophora following the eradication of schistosomiasis japonica in Yamanashi Prefecture, Japan2009

    • Author(s)
      Nihei N, Komagata O, Kobayashi M, Saitoh Y, Mochizuki K, Nakamura S
    • Journal Title

      Jpn J Infect Dis

      Volume: 62 Pages: 125-32

    • NAID

      40016533919

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] 中国のOncomelania属貝と日本住血吸虫症の動向2012

    • Author(s)
      太田伸生、熊谷貴、陸紹紅、王天平、温礼永
    • Organizer
      第64回日本衛生動物学会シンポジウム
    • Place of Presentation
      上田市
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] IL-4/IL-13 suppress excessive granulomatous inflammation in schistosomiasis japonica2011

    • Author(s)
      Seki T, Kumagai T, Kwansa-Bentum B, Furushima-Shimogawara R, AnyanWK, Miyazawa Y, Iwakura Y, Ohta N
    • Organizer
      Joint SATREPS Workshop on Climate-Ecosystem Changes, Global Health and Human Wellbeing in West Africa
    • Place of Presentation
      Legos, Ghana
    • Year and Date
      2011-12-03
    • Related Report
      2011 Final Research Report
  • [Presentation] IL-4/IL-13 suppress excessive granulomatous inflammation in schistosomiasis japonica2011

    • Author(s)
      Seki T, Kumagai T, Kwansa-Bentum B, Furushima-Shimogawara R, Anyan WK, Miyazawa Y, Iwakura Y, Ohta N
    • Organizer
      Joint SATREPS Workshop on Climate-Ecosystem Changes, Global Health and Human Wellbeing in West Africa
    • Place of Presentation
      Legon, Ghana
    • Year and Date
      2011-12-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] Neglected tropical diseases : New challenges for research promotion2010

    • Author(s)
      Ohta N
    • Organizer
      XII^<th> International Congress for Parasitology
    • Place of Presentation
      Melbourne
    • Related Report
      2011 Final Research Report
  • [Presentation] Climate change and infectious diseases : Probable influences on disease-transmitting vectors in Japan2010

    • Author(s)
      Nihei N, Tokiwa T, Kobayashi M, Akao N, Ohta N
    • Organizer
      2^<nd> International Conference on Climate Change and Neglected Tropical Diseases
    • Place of Presentation
      Dhakka
    • Related Report
      2011 Final Research Report
  • [Presentation] Schistosomiasis research in Japan : Overview of current situation2010

    • Author(s)
      Ohta N
    • Organizer
      10^<th> Conference of RNAS(Regional Network for Asian Schistosomiasis)+
    • Place of Presentation
      Wuxi, China
    • Related Report
      2011 Final Research Report
  • [Presentation] Using ALOS satellite images to develop efficient measures against vector-borne diseases-egional differences in outbreak risk for schistosomiasis japonica in China2010

    • Author(s)
      Nihei N, Komagata O, Kobayashi M, Ohta N, Saitoh Y, Mochizuki K, Chen R, Lu SH, Wen LY, Wang TP
    • Organizer
      4^<th> ALOS Joint PI Symposium of ALOS Data Nodes
    • Place of Presentation
      Tokyo
    • Related Report
      2011 Final Research Report
  • [Presentation] Neglected tropical diseases : New challenges for research promotion.2010

    • Author(s)
      Ohta N
    • Organizer
      XII^<th>International Congress for Parasitology
    • Place of Presentation
      Melbourne, Australia
    • Related Report
      2010 Annual Research Report
  • [Presentation] Climate change and-infectious diseases : Probable influences on disease-transmitting vectors in Japan.2010

    • Author(s)
      Nihei N, Tokiwa, Kibayashi M, Akao N, Ohta N.
    • Organizer
      2^<nd> International Conference on Climate Change and Neglected Tropical Diseases 2010
    • Place of Presentation
      Dhaka, Bangladesh
    • Related Report
      2010 Annual Research Report
  • [Presentation] Schistosomiasis research in Japan Overview of current situation.2010

    • Author(s)
      Ohta N.
    • Organizer
      10^<th> Conference of RNAS(Regional Network forAsian Schistosomiasis)+
    • Place of Presentation
      Wuxi, China
    • Related Report
      2010 Annual Research Report
  • [Presentation] Using ALOS satellite images to develop efficient measures against vector-borne diseases-Regional differences in outbreake risk for scbistosomiaxis japonica in China.2010

    • Author(s)
      Nihei N, Komagata O, Kobayashi M, Ohta N, Saitoh Y, Mochizuki K, Chen R, Lu SH, Wen LY, Wang TP.
    • Organizer
      4^<th> ALOS Joint PI Symposium of ALOS Data Nodes.
    • Place of Presentation
      Tokyo, Japan.
    • Related Report
      2010 Annual Research Report
  • [Presentation] 中国における日本住血吸虫症の分布におよぼす温暖化の影響2010

    • Author(s)
      二瓶直子、駒形修、小林睦生、斎藤秀康、望月貫一郎、陸紹紅、陳睿、聞礼永、王天平、太田伸生
    • Organizer
      第28回国際保健医療学会西日本地方会
    • Place of Presentation
      長崎市
    • Related Report
      2009 Annual Research Report
  • [Presentation] Advances in biological research of tropical medicine and its role for global control of NTD2009

    • Author(s)
      Ohta N
    • Organizer
      51^<st> Korean Soc Parasitol
    • Place of Presentation
      Seoul
    • Related Report
      2011 Final Research Report
  • [Presentation] Surveillance for schistosomiasis after the interruption of transmission in Japan2009

    • Author(s)
      Ohta N
    • Organizer
      第51回日本熱帯医学会総会
    • Place of Presentation
      宜野湾市
    • Related Report
      2011 Final Research Report
  • [Presentation] Advances in biological research of tropical medicine and its role for global control of NTD.2009

    • Author(s)
      太田伸生
    • Organizer
      第51回韓国寄生虫学会大会
    • Place of Presentation
      Seoul
    • Related Report
      2009 Annual Research Report
  • [Presentation] Surveillance for schistosomiasis after the interruption of transmission in Japan.2009

    • Author(s)
      太田伸生
    • Organizer
      第50回日本熱帯医学会総会
    • Place of Presentation
      宜野湾市
    • Related Report
      2009 Annual Research Report
  • [Book] Final Reports of the ALOS Research Announcement Programs 1&2, 20112011

    • Author(s)
      Nihei N, Komagata O, Kobayashi M, Ohta N, Sautoh Y, Mochizuki K, Chen R, Lu S, Wen L, Wang T
    • Total Pages
      6
    • Publisher
      Using ALOS satellite images to develop efficient measures against vector-borne diseases-Regional differences in outbreak risk of schistosomiasis in China
    • Related Report
      2011 Annual Research Report
  • [Book] 日本における伝染病との闘いの歴史2010

    • Author(s)
      太田伸生、保阪幸男
    • Publisher
      科学評論社
    • Related Report
      2011 Final Research Report
  • [Book] 日本における伝染病との闘いの歴史(菅又昌実編著)2010

    • Author(s)
      太田伸生、保阪幸男
    • Publisher
      医学評論社
    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] 新規抗住血吸虫剤2009

    • Inventor(s)
      綿矢有佑、金恵淑、平本晃子、佐藤聡、太田伸生、熊谷貴、下河原理江子、谷口斎恵
    • Industrial Property Rights Holder
      岡山大学
    • Acquisition Date
      2009
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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