| Project/Area Number |
21406019
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Hygiene
|
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| Research Institution | Suzuka University of Medical Science |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MURATA Mariko 三重大学, 大学院・医学系研究科, 教授 (10171141)
HIRAKU Yusuke 三重大学, 大学院・医学系研究科, 講師 (30324510)
MA Nei 鈴鹿医療科学大学, 保健衛生学部, 教授 (30263015)
OHNISHI Shiho 鈴鹿医療科学大学, 薬学部, 助手 (80511914)
INOUE Sumiko 鈴鹿医療科学大学, 薬学部, 准教授 (20378657)
CHINZEI Yasuo 鈴鹿医療科学大学, 医用工学部, 教授 (60024709)
|
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| Co-Investigator(Renkei-kenkyūsha) |
OIKAWA Shinji 三重大学, 大学院・医学系研究科, 准教授 (10277006)
|
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| Research Collaborator |
YONGVANIT P. コンケーン大学, 教授
THANAN R. 鈴鹿医療科学大学, ポスト・ドクター
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2011: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2010: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2009: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Keywords | DNA損傷 / 感染 / 炎症 / がん予防 / 酸化ストレス / 胆管癌 / 肝吸虫 / 8-ニトログアニン |
|---|
| Research Abstract |
Cholangiocarcinoma(CCA) is associated with chronic inflammation caused by liver fluke infection. Stem cell markers(CD133, OV6, CK-19) and DNA base damage(8-oxodG, 8-nitroguanine) were clearly colocalized in CCA. We identified 14 highly carbonylated proteins in CCA tissues. The oxidative modification of these proteins was significantly associated with poor prognoses as determined by the Kaplan-Meier method.
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