Prevention and prediction of oral carcinogenesis for betel quid chewers

• Project/Area Number: 21406030
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Surgical dentistry
• Research Institution: Health Sciences University of Hokkaido
• Principal Investigator: CHIBA Itsuro 北海道医療大学, 歯学部, 教授 (50250460)
• Co-Investigator(Kenkyū-buntansha): ABIKO Yoshihiro 北海道医療大学, 医科学センター, 教授 (90260819) ; 角館 直樹 (角舘 直樹) 北海道医療大学, 歯学部, 助教 (20534449)
• Project Period (FY): 2009 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000); Fiscal Year 2012: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2010: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2009: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
• Keywords: 口腔がん / 予防 / 介入研究 / スリ / ランカ / バイオマーカー / 噛みタバコ / アジア / 抗酸化剤 / がん予防

Research Abstract

Intervention study using anti-oxidant has performed in betel quid chewers who have oral precancer and the lesion size was significantly decreased.

Research Products

• [Journal Article] Lipopolysaccharide extracted from Porphyromonas gingivalis induces DNA hypermethylation of runt-related transcription factor 2 in human periodontal fibroblasts (2012)
  • Author(s): Uehara O, Abiko Y, Saitoh M, Miyakawa H, Nakazawa F
  • Journal Title: J Microbiol Immunol Infect
• [Journal Article] Expression profile of drosomycin-like defencin in oral epithelium and oral carcinoma cell lines (2012)
  • Author(s): Sato J., Nishimura M., Yamazaki M., Yoshida K., Kurashige Y., Saitoh M., Abiko Y
  • Journal Title: Arch. Oral Biol Volume: (Epub ahead of print)
• [Journal Article] Current evidence on atypical odontalgia: diagnosis and clinical management. (2012)
  • Author(s): Abiko Y, Matsuoka H, Chiba I, Toyofuku A.
  • Journal Title: Int J Dent Volume: 2012 Pages: 518-548
  • DOI: 10.1155/2012/518548
  • Peer Reviewed
• [Journal Article] Lipopolysaccharide extracted from Porphyromonas gingivalis induces DNA hypermethylation of runt-related transcription factor 2 in human periodontal fibroblasts. (2012)
  • Author(s): Uehara O, Abiko Y, Saitoh M, Miyakawa H, Nakazawa F.
  • Journal Title: J Microbiol Immunol Infect Volume: 12 Issue: 3 Pages: 176-181
  • DOI: 10.1016/j.jmii.2012.08.005
  • Peer Reviewed / Open Access
• [Journal Article] A polymerase chain reaction-based method for constructing a linear vector with site-specific DNA methylation (2011)
  • Author(s): Arakawa T, Ohta T, Abiko Y, Okayama M, Mizoguchi I, Takuma T
  • Journal Title: Anal Biochem Volume: 416(2):211-7
• [Journal Article] Association between self-efficacy and loss to follow-up in long-term periodontal treatment (2010)
  • Author(s): Kakudate N, Morita M, Yamazaki S, Fukuhara S, Sugai M, Nagayama M, Kawanami M, Chiba I
  • Journal Title: J Clin Periodontol Volume: 37(3):276-82
• [Presentation] Curcumin is an effective chemopreventive substance for betel quid chewer's oral precancer in Sri Lanka (2012)
  • Author(s): I Chiba, M Muthumala, C Sugiura, M Onodera, T Shibata, H Matsuoka, N Kakudate, Shunichi Fukuhara, T Takiguchi, M Takeshima, Y Abiko, H Kobayashi
  • Organizer: AACR
  • Place of Presentation: Anaheim, CA
• [Presentation] Curcumin is an effective chemopreventive substance for betel quid chewer’s oral precancer in Sri Lanka.
  • Author(s): Itsuo Chiba et al.
  • Organizer: Frontiers in Cancer prevention and Research
  • Place of Presentation: Anaheim, LA, USA