| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
We first succeeded in generating gene-targeting mice for the dihydropteridine reductase gene. The mice exhibited deficiency in the serotonin contents in the brain and PTSD-like behaviors in a battery of behavioral test. In this study, we explored the molecular mechanism for these abnormalities in the mice. We found that hyperphenylalaninemia in the mice can cause serotonin deficiency in the brain, and that a low-phenylalanine diet deteriorated the serotonin-deficiency in the mice.
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