Biological importance of the formation of subventricular zone during the cortical development

• Project/Area Number: 21500330
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Keio University
• Principal Investigator: TABATA Hidenori 慶應義塾大学, 医学部, 講師(非常勤) (80301761)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 神経科学 / 脳・神経 / 発生・分化 / 解剖学 / 神経回路 / 神経細胞移動 / 神経発生 / 大脳皮質 / 細胞移動

Research Abstract

During the development of mammalian cerebral cortex, cortical neurons are generated in the ventricular zone lining the ventricle, or in the subventricular zone (SVZ), and migrate toward the brain surface. The neurogenesis in the SVZ is greatly enhanced in

Research Products

• [Journal Article] Robo1 regulates the migration and laminar distribution of upper-layer pyramidal neurons of the cerebral cortex (2013)
  • Author(s): Yuko Gonda
  • Journal Title: Cereb. Cortex Volume: 未定
  • Peer Reviewed
• [Journal Article] 大脳皮質発生過程における脳室下帯分裂細胞の動態解析 (2013)
  • Author(s): 田畑秀典
  • Journal Title: 日本神経精神薬理学雑誌 Volume: 未定
  • NAID: 10031184213
• [Journal Article] 子宮内電気穿孔法により見えて来た大脳皮質形成のメカニズム (2013)
  • Author(s): 田畑秀典
  • Journal Title: 神経化学 Volume: 52 Pages: 22-30
• [Journal Article] A phosphatidylinositol lipids system, Lamellipodin and Ena/VASP regulate dynamic morphology of multipolar migrating cells in the developing cerebral cortex (2012)
  • Author(s): Satoshi Yoshinaga, TakahiroOhkubo, Shinji Sasaki, Mutsuo Nuriya, Yukino Ogawa, Masato Yasui, Hidenori Tabata, and Kazunori Nakajima.
  • Journal Title: J. Neurosci. Volume: 32(34) Pages: 11643-11656
  • Peer Reviewed
• [Journal Article] Cytoarchitecture of mouse and human subventricular zone in developing cerebral neocortex. (2012)
  • Author(s): Hidenori Tabata, Satoshi Yoshinaga, and Kazunori Nakajima.
  • Journal Title: Exp. Brain Res Volume: 216 (2) Pages: 161-168
  • Peer Reviewed
• [Journal Article] A phosphatidylinositol lipids system, Lamellipodin and Ena/VASP regulate dynamic morphology of multipolar migrating cells in the developing cerebral cortex (2012)
  • Author(s): Satoshi Yoshinaga
  • Journal Title: J. Neurosci. Volume: 32 Issue: 34 Pages: 11643-11656
  • DOI: 10.1523/jneurosci.0738-12.2012
  • Peer Reviewed
• [Journal Article] Cytoarchitecture of mouse and human subventricular zone in developing cerebral neocortex (2012)
  • Author(s): Hidenori Tabata
  • Journal Title: Exp. Brain Res. Volume: 216 Issue: 2 Pages: 161-168
  • DOI: 10.1007/s00221-011-2933-3
  • Peer Reviewed
• [Journal Article] Segregation and pathfinding of callosal axons through EphA3 signaling. (2011)
  • Author(s): Mitsuaki Nishikimi, Koji Oishi, Hidenori Tabata, Kenichi Torii, and Kazunori Nakajima.
  • Journal Title: J. Neurosci. Volume: 31(45) Pages: 16251-16260
  • Peer Reviewed
• [Journal Article] Neural crest-derived stem cells migrate and differentiate into cardiomyocytes after myocardial infarction. (2011)
  • Author(s): Yuichi Tamura, Keisuke Matsumura, Motoaki Sano, Hidenori Tabata, Kensuke Kimura, Masaki Ieda, Takahide Arai, Yohei Ohno, Hideaki Kanazawa, Shinsuke Yuasa, Ruri Kaneda, Shinji Makino, Kazunori Nakajima, Hideyuki Okano, and Keiichi Fukuda
  • Journal Title: Arterioscler. Thromb. Vasc. Biol. Volume: 31 (3) Pages: 582-589
  • Peer Reviewed
• [Journal Article] Cellular composition and organization of the subventricular zone and rostral migratory stream in the adult and neonatal common marmoset brain (2011)
  • Author(s): Kazunobu Sawamoto, Yuki Hirota, Clara Alfaro-Cervello, Mario Soriano-Navarro, Xiaoping He, Yoshika Hayakawa-Ya no , Masayuki Yamada, Keigo Hikishima, Hidenori Tabata, Akio Iwanami, Kazunori Nakajima, Yoshiaki Toyama, Toshio Itoh, Arturo Alvarez-Buylla, Jo
  • Journal Title: J. Comp. Neurol. Volume: 519 (4) Pages: 690-713
  • Peer Reviewed
• [Journal Article] Segregation and pathfinding of callosal axons through EphA3 signaling (2011)
  • Author(s): Mitsuaki Nishikimi
  • Journal Title: J. Neurosci. Volume: 31 Issue: 45 Pages: 16251-16260
  • DOI: 10.1523/jneurosci.3303-11.2011
  • Peer Reviewed
• [Journal Article] Neural crest-derived stem cells migrate and differentiate into cardiomyocytes after myocardial infarction (2011)
  • Author(s): Yuichi Tamura
  • Journal Title: Arterioscler. Thromb. Vasc. Biol. Volume: 31 Issue: 3 Pages: 582-589
  • DOI: 10.1161/atvbaha.110.214726
  • Peer Reviewed
• [Journal Article] Cellular composition and organization of the subventricular zone and rostral migratory stream in the adult and neonatal common marmoset brain. (2011)
  • Author(s): Kazunobu Sawamoto, et al.
  • Journal Title: J.Comp.Neurol. Volume: 519 Pages: 690-713
  • Peer Reviewed
• [Journal Article] Ectopic Reelin induces neuronalaggregation with a normal birthdate-dependent "inside-out" alignment in the developing neocortex. (2010)
  • Author(s): Ken-ichiro Kubo, Takao Honda, Kenji Tomita, Katsutoshi Sekine, Kazuhiro Ishii, Asuka Uto, Kazuma Kobayashi, Hidenori Tabata, and Kazunori Nakajima.
  • Journal Title: J. Neurosci. Volume: 30 (33) Pages: 10953-10966
  • Peer Reviewed
• [Journal Article] Inhibition of N-methyl-d-aspartate receptor activity resulted in aberrant neuronal migration caused by delayed morphological development in the mouse neocortex. (2010)
  • Author(s): Shigeo Uchino, Takae Hirasawa, Hidenori Tabata, Yuko Gonda, ChikakoWaga, Yumiko Ondo, Kazunori Nakajima, and Shinichi Kohsaka
  • Journal Title: Neuroscience Volume: 169 Pages: 609-618
  • Peer Reviewed
• [Journal Article] Role of dual leucine zipper-bearing kinase (DLK/MUK/ZPK) in axonal growth. (2010)
  • Author(s): Kaoru Eto, Takeshi Kawauchi, Makiko Osawa, Hidenori Tabata, and Kazunori Nakajima.
  • Journal Title: Neurosci. Res Volume: 66 Pages: 37-45
  • Peer Reviewed
• [Journal Article] Ectopic Reelin induces neuronal aggregation with a normal birthdate-dependent "inside-out" alignment in the developing neocortex. (2010)
  • Author(s): Ken-ichiro Kubo, et al.
  • Journal Title: J.Neurosci. Volume: 30(33) Pages: 10953-10966
  • Peer Reviewed
• [Journal Article] Role of dual leucine zipper-bearing kinase (DLK/MUK/ZPK) in axonal growth. (2010)
  • Author(s): Kaoru Eto, et al.
  • Journal Title: Neurosci.Res. Volume: 66 Pages: 37-45
  • Peer Reviewed
• [Presentation] 招待講演:大脳皮質発生過程における脳室下帯分裂細胞の動態解析 (2013)
  • Organizer: 田畑秀典第54回「脳の医学・生物学研究会」
  • Place of Presentation: 名古屋
  • Year and Date: 2013-02-16
• [Presentation] マウス大脳皮質発生過程における脳室下帯分裂細胞の産生と維持の調節 (Regulation of the production and maintenance of the progenitors in the subventricular zone during the mouse cortical development) (2012)
  • Author(s): 田畑秀典、八谷剛史、榊原康文、仲嶋一範
  • Organizer: 第35回日本神経科学大会、名古屋国際会議場
  • Place of Presentation: 名古屋(愛知県)
• [Presentation] マウス大脳皮質発生過程における脳室下帯分裂細胞の産生と維持の調節 (2012)
  • Author(s): 田畑秀典
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋
• [Presentation] 霊長類進化過程で大脳皮質発達に寄与した遺伝子の機能的、生物情報科学的探索(Functional and bioinformatic screening for the genes involved in the expansion of cerebral cortex during the primate evolution) (2011)
  • Author(s): 田畑秀典、八谷剛史、榊原康文、仲嶋一範
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
• [Presentation] Migration profile of glial progenitors derived from the cerebral cortical ventricular zone (2011)
  • Author(s): Hidenori Tabata, Megumi Sasaki, Hirohide Takebayashi, Kazuhiro Ikenaka, and Kazunori Nakajima
  • Organizer: Conference on "Frontiers in Cell Migration & Mechanotransduction"
  • Place of Presentation: Bethesda, MD, U.S.A.
• [Presentation] 霊長類進化過程で大脳皮質発達に寄与した遺伝子の機能的、生物情報科学的探索 (2011)
  • Author(s): 田畑秀典
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
• [Presentation] Screening for the genes that are involved in the production of non-surface-dividing cells during neocortical development and their evolutionary analyses (2011)
  • Author(s): Hidenori Tabata, et al.
  • Organizer: 第88回日本生理学会大会 第116回日本解剖学会総会・全国学術集会 合同大会
  • Place of Presentation: (集会中止のため、誌上発表)
• [Presentation] 皮質脳室帯に由来するグリア前駆細胞の移動様式(The migration of glial progenitors derived from the cortical ventricular zone) (2010)
  • Author(s): 田畑秀典、佐々木恵、竹林浩秀、池中一裕、仲嶋一範
  • Organizer: 第33回日本神経科学大会・第53回日本神経化学会大会・第20回日本神経回路学会大会合同大会(Neuro2010)
  • Place of Presentation: 神戸
• [Presentation] 哺乳類大脳皮質形成後期において分裂を伴い速く移動する細胞集団の解析(Investigation of the cell population that migrates quickly and divides during the late cortical plate development) (2010)
  • Author(s): 田畑秀典、佐々木恵、仲嶋一範
  • Organizer: 第115回日本解剖学会総会・全国学術集会
  • Place of Presentation: 盛岡
• [Presentation] 大脳皮質発生において多極性移動神経細胞は2種類の異なる突起を伸長・退縮させる (Multipolar migrating neurons in the developing cerebral cortex have two distinct types of processes) (2010)
  • Author(s): 吉永怜史、大久保宇啓、佐々木慎二、田畑秀典、仲嶋一範
  • Organizer: 第115回日本解剖学会総会・全国学術集会
  • Place of Presentation: 盛岡
• [Presentation] 2種類の前駆細胞によるマウス大脳皮質錐体神経細胞産生の定量的解析 (2010)
  • Author(s): 田畑秀典、仲嶋一範
  • Organizer: 定量生物学の会 第二回年会
  • Place of Presentation: 大阪
• [Presentation] 大脳皮質発生におけるリーリン分子の機能の再解析 (2010)
  • Author(s): 久保健一郎, 等
  • Organizer: 第33回日本神経科学大会・第53回日本神経化学会大会・第20回日本神経回路学会大会合同大会(Neuro2010)
  • Place of Presentation: 神戸
• [Presentation] 皮質脳室帯に由来するグリア前駆細胞の移動様式 (2010)
  • Author(s): 田畑秀典, 等
  • Organizer: 第33回日本神経科学大会・第53回日本神経化学会大会・第20回日本神経回路学会大会合同大会(Neuro2010)
  • Place of Presentation: 神戸
• [Presentation] Robo1は大脳皮質錐体細胞の形態形成を調節している (2010)
  • Author(s): 権田裕子, 等
  • Organizer: 第33回日本神経科学大会・第53回日本神経化学会大会・第20回日本神経回路学会大会合同大会(Neuro2010)
  • Place of Presentation: 神戸
• [Presentation] Novel method 'Fucci' elucidated the native cell-cycle dynamics in developing and ischemic cardiomyocytes (2010)
  • Author(s): Hisayuki Hashimoto, et al.
  • Organizer: XXth World Congress of the International Society for Heart Research
  • Place of Presentation: 京都
• [Presentation] 大脳皮質発生において多極性移動神経細胞は2種類の異なる突起を伸長・退縮させる (2010)
  • Author(s): 吉永怜史, 等
  • Organizer: 第115回日本解剖学会総会・全国学術集会
  • Place of Presentation: 盛岡
• [Presentation] 哺乳類大脳皮質形成後期において分裂を伴い速く移動する細胞集団の解析 (2010)
  • Author(s): 田畑秀典, 等
  • Organizer: 第115回日本解剖学会総会・全国学術集会
  • Place of Presentation: 盛岡
• [Presentation] 軸索ガイダンス分子Robo 1の大脳皮質形成過程における役割 (2009)
  • Author(s): 権田裕子, 等
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
• [Presentation] Investigation of the role of Reelin in vivo using in utero electroporation system (2009)
  • Author(s): Ken-ichiro Kubo, et al.
  • Organizer: International Symposium "Construction and Reconstruction of the Brain
  • Place of Presentation: Awaji
• [Presentation] 大脳皮質錐体細胞の発達段階におけるRoundabout1(Robo1)の役割 (2009)
  • Author(s): 権田裕子, 等
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
• [Presentation] Screening for the genes that are involved in the production of non-surface-dividing cells during neocortical development and their evolutionary analyses
  • Author(s): Hidenori Tabata, Tsuyoshi Hachiya, Yasubumi Sakakibara, and Kazunori Nakajima(田畑秀典、八谷剛史、榊原康文、仲嶋一範)
  • Organizer: 第88回日本生理学会大会 第116回日本解剖学会総会・全国学術集会 合同大会
• [Presentation] 大脳皮質発生過程における脳室下帯分裂細胞の動態解析
  • Author(s): 田畑秀典
  • Organizer: 脳の医学・生物学研究会
  • Place of Presentation: 名古屋
  • Invited
• [Book] In utero electroporation ; assay system for migration of cerebral cortical neurons. Electroporation and Sonoporation in Developmental Biology (Editor : Harukazu Nakamura) (2009)
  • Author(s): Hidenori Tabata, et al.
  • Total Pages: 9
  • Publisher: Springer
• [Remarks]
  • URL: http://web.sc.itc.keio.ac.jp/anatomy/nakajima/index.html
• [Remarks]
  • URL: http://web.sc.itc.keio.ac.jp/anatomy/nakajima/index.html