Biochemical analyses of Ufm1-modification of proteins in the synapse
| Project/Area Number |
21500347
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Shinshu University |
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Principal Investigator |
SUZUKI Tatsuo 信州大学, 医学系研究科, 教授 (80162965)
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| Co-Investigator(Kenkyū-buntansha) |
TANAHASHI Hiroshi 信州大学, 医学系研究科, 准教授 (90236654)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | シナプス / PSD / シナプス後肥厚部 / タンパク質修飾 |
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| Research Abstract |
Ufm1(Ubiquitin-fold modifier 1) is a most recently identified ubiquitination-like protein modification tag. Using anti-Ufc1(Ufm-conjugating E2-like enzyme) and anti-Ufm1 antibodies that were produced by us, localization of Ufc1 and Ufm1 in the brain and cultures neurons was identified. The substrate proteins that receive Ufm1-modification were surveyed in the brain.
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Report
(4 results)
Research Products
(37 results)
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[Journal Article] SynArfGEF is a guanine nucleotide exchange factor for Arf6 and localise preferentially at postsynaptic specializations of inhibitory synapses.2010
Author(s)
Fukaya M, Kamata A, Hara Y, Tamaki H, Katsumata O,Ito N, Takeda S, Hata Y, Suzuki T, Watanabe M, Harvey RJ, Sakagami H
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Journal Title
J.Neurochem.
Volume: 116
Pages: 1122-1137
Related Report
Peer Reviewed
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[Presentation] Association of membrane rafts and postsynaptic density : Proteomics, biochemical, and ultrastructural analyses2010
Author(s)
Suzuki, T., Zhang, J-P., Farzan, M. R., Miyazawa, S., Liu, Q., Yao W-D
Organizer
SFN
Place of Presentation
San Diego
Year and Date
2010-11-15
Related Report
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[Presentation] Analysis of postsynaptic membrane rafts and comparison with postsynaptic density prepared from synaptic plasma membrane2010
Author(s)
Suzuki, T., Zhang, J-P., Farzan, M. R., Miyazawa, S., Liu, Q., Yao W-D
Organizer
APSN2010
Place of Presentation
Phuket, Thai
Year and Date
2010-10-18
Related Report
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[Presentation] Analysis of postsynaptic membrane rafts and comparison with postsynaptic density prepared from synaptic plasma membrane.2010
Author(s)
SuzuKi, T., Zhang, J-P., Farzan, M.R., Miyazawa, S., Liu, Q., Yao W-D.
Organizer
APSN2010
Place of Presentation
Phuket, Thai
Year and Date
2010-10-18
Related Report
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[Presentation] Relationship between postsynaptic density and membrane rafts at the postsynaptic sites.シナプス後肥厚部-メンブランラフト複合体の解析2010
Author(s)
Suzuki, T., Zhang, J-P., Farzan, M. R., Miyazawa, S., Liu, Q., Yao W-D
Organizer
神経化学/神経科学
Place of Presentation
Kobe
Year and Date
2010-09-03
Related Report
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