Purinergic circuit formation at the critical period in the mouse retina

• Project/Area Number: 21500373
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurophysiology and muscle physiology
• Research Institution: Keio University
• Principal Investigator: KANEDA Makoto 慶應義塾大学, 医学部, 准教授 (30214480)
• Co-Investigator(Kenkyū-buntansha): KANEKO Akimichi 畿央大学, 健康科学部, 教授 (00051491)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 神経 / 筋肉生理学 / マウス / P2X2プリン受容体 / 網膜 / ATP

Research Abstract

Circuit formation of visual system occurs before the critical period and did not show any plastic change to visual experience. Since circuit formation of P2X2-purinoceptor occurs in the critical period, we examined whether the circuit formation of P2X2-purinoceptor shows plastic change to visual experience in the mouse retina. We found that the circuit formation of P2X2-purinoceptors did not show any plastic change to visual experience, suggesting the presence of intrinsically programmed process.

Research Products

• [Journal Article] The OFF-pathway dominance of P2X2-purinoceptors is formed without visual experience (2010)
  • Author(s): Kaneda, M., Ito, K., Shigematsu, Y., Shimoda, Y
  • Journal Title: Neurosci. Res Volume: 66 Pages: 86-91
• [Journal Article] Deletions of SCN1A 5' genomic region with promoter activity in Dravet syndrome (2010)
  • Author(s): Nakayama, T., Ogiwara I., Ito K., Kaneda M., Mazaki E., Osaka H., Ohtani H., Inoue Y., Fujiwara T., Uematsu M., Haginoya K., Tsuchiya S., Yamakawa K
  • Journal Title: Hum. Mutat Volume: 31 Pages: 820-829
• [Journal Article] The OFF-pathway dominance of P2X2-purinoceptors is formed without visual experience. (2010)
  • Author(s): Kaneda, M., Ito, K., Shigematsu, Y., Shimoda, Y.
  • Journal Title: Neurosci.Res. Volume: 66 Pages: 86-91
  • Peer Reviewed
• [Journal Article] Deletions of SCN1A 5' genomic region with promoter activity in Dravet syndrome. (2010)
  • Author(s): Nakayama, T., Ogiwara I., Ito K., Kaneda M., Mazaki E., Osaka H., Ohtani H., Inoue Y., Fujiwara T., Uematsu M., Haginoya K., Tsuchiya S., Yamakawa K.
  • Journal Title: Hum.Mutat. Volume: 31 Pages: 820-829
  • Peer Reviewed
• [Journal Article] The OFF-pathway dominance of P2X2-purinoceptors is formed without visual experience (2010)
  • Author(s): Kaneda, M., Ito, K., Shigematsu, Y., Shimoda, Y.
  • Journal Title: Neurosci.Res. 66 Pages: 86-91
  • Peer Reviewed
• [Presentation] マウス網膜で見られる経路特異的なグリシン応答 (2012)
  • Author(s): 金田誠
  • Organizer: 第89回日本生理学会大会
  • Place of Presentation: 長野県松本文化会館(長野)
  • Year and Date: 2012-03-31
• [Presentation] マウス網膜で見られる経路特異的なグリシン応答 (2012)
  • Author(s): 金田誠
  • Organizer: 第89回日本生理学会大会
  • Place of Presentation: 松本
  • Year and Date: 2012-03-30
• [Presentation] コリン作動性ニューロンに見られるP2X型プリン受容体陽イオンチャネルを介したコリンの細胞内輸送系 (2011)
  • Author(s): 金田誠、重松康秀、霜田幸雄、井上浩義
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川)
  • Year and Date: 2011-09-16
• [Presentation] マウス網膜ON型とOFF型コリン作動性ニューロンは異なるグリシン応答を示す (2011)
  • Author(s): 金田誠
  • Organizer: 第15回視覚科学フォーラム
  • Place of Presentation: 大阪大学基礎工学部(大阪)
  • Year and Date: 2011-08-30
• [Presentation] Purinergic receptors in cholinergic amacrine cells (2011)
  • Author(s): Kaneda, M.
  • Organizer: The 9^<th> biennial conference of the Chinese neuroscience society and 5^<th> member congress
  • Place of Presentation: Zhengzhou, China(招待講演)
  • Year and Date: 2011-07-31
• [Presentation] コリン作動性ニューロンに見られるP2X型プリン受容体陽イオンチャネルを介したコリンの細胞内輸送系 (2011)
  • Author(s): 金田誠、重松康秀、霜田幸雄、井上浩義
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜市
• [Presentation] マウス網膜ON型とOFF型コリン作動性ニューロンは異なるグリシン応答を示す (2011)
  • Author(s): 金田誠
  • Organizer: 第15回視覚科学フォーラム
  • Place of Presentation: 大阪大学基礎工学部J棟
• [Presentation] Purinergic receptors in cholinergic amacrine cells (2011)
  • Author(s): Kaneda M
  • Organizer: The 9^<th> Biennial Conference of the Chinese Neuroscience Society and the 5^<th> Member Congress
  • Place of Presentation: Zhengzhou China
• [Presentation] P2X2-purinoceptor can be a choline transport pathway in the OFF-cholinergic amacrine cells in the mouse retina (2010)
  • Author(s): Kaneda, M., Shigemastu, Y., Shimoda, Y
  • Organizer: 40th Annual Meeting of Neuroscience
  • Place of Presentation: San Diego, USA
  • Year and Date: 2010-11-17
• [Presentation] P2X2-purinoceptor can be a choline transport pathway in the OFF-cholinergic amacrine cells in the mouse retina. (2010)
  • Author(s): Kaneda, M., Shigemastu, Y., Shimoda, Y.
  • Organizer: 40th Annual Meeting of Neuroscience
  • Place of Presentation: San Diego, USA
  • Year and Date: 2010-11-17
• [Presentation] 電位依存性ナトリウムチャネルα2遺伝子とてんかん (2010)
  • Author(s): 荻原郁夫、中山東城、真崎恵美、井上育代、伊藤公一、金田誠、宮本浩行、Takao K. Hensch、沢石由記夫、小坂仁、藤原建樹、井上有史、山川和弘
  • Organizer: 第54回日本人類遺伝学会
  • Place of Presentation: 大宮市
  • Year and Date: 2010-10-30
• [Presentation] 難治てんかんに認められたde novo電位依存性ナトリウムチャネルα2遺伝子変異 (2010)
  • Author(s): 荻原郁夫、真崎恵美、井上育代、伊藤公一、金田誠、沢石由記夫、小坂仁、藤原建樹、井上有史、山川和弘
  • Organizer: 第44回日本てんかん学会
  • Place of Presentation: 岡山市
  • Year and Date: 2010-10-14
• [Presentation] 動性アマクリン細胞で見られる二種類のコリン輸送 (2010)
  • Author(s): 金田誠、重松康秀、霜田幸雄
  • Organizer: 第14回視覚科学フォーラム
  • Place of Presentation: 筑波大学大学会館、つくば市
  • Year and Date: 2010-08-26
• [Presentation] コリン作動性アマクリン細胞で見られる二種類のコリン輸送 (2010)
  • Author(s): 金田誠、重松康秀、霜田幸雄
  • Organizer: 第14回視覚科学フォーラム
  • Place of Presentation: 筑波大学大学会館、つくば市
  • Year and Date: 2010-08-26
• [Presentation] Two choline transport pathways in cholinergic amacrine cells in the mouse retina (2010)
  • Author(s): Kaneda, M., Shigemastu, Y., Shimoda, Y
  • Organizer: The 6th Asia-Pacific Conference on Vision
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2010-07-23
• [Presentation] Two choline transport pathways in cholinergic amacrine cells in the mouse retina. (2010)
  • Author(s): Kaneda, M., Shigemastu, Y., Shimoda, Y.
  • Organizer: The 6th Asia-Pacific Conference on Vision
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2010-07-23
• [Presentation] マウス網膜P2型プリン受容体を介する経路特異的な応答修飾 (2010)
  • Author(s): 金田誠、石井俊行、細谷俊彦
  • Organizer: 第40回慶応ニューロサイエンス研究会
  • Place of Presentation: 慶應義塾大学医学部、東京都新宿区
  • Year and Date: 2010-05-29
• [Presentation] マウス網膜P2型プリン受容体を介する経路特異的な応答修飾 (2010)
  • Author(s): 金田誠、石井俊行、細谷俊彦
  • Organizer: 第40回慶応ニューロサイエンス研究会
  • Place of Presentation: 慶応義塾大学医学部、東京都新宿区
  • Year and Date: 2010-05-29
• [Presentation] マウス網膜臨界期に形成されるP2X型プリン受容体神経回路 (2009)
  • Author(s): 金田誠、伊藤公一、重松康秀、霜田幸雄
  • Organizer: 第32回日本神経科学会大会シンポジウム
  • Place of Presentation: 名古屋市
  • Year and Date: 2009-09-16
• [Presentation] マウス網膜P2X2型プリン受容体の発達は開眼後にはじまる (2009)
  • Author(s): 金田誠、伊藤公一、重松康秀、霜田幸雄
  • Organizer: 第13回視覚科学フォーラム
  • Place of Presentation: 鹿児島大学工学部稲盛会館
  • Year and Date: 2009-09-03
• [Presentation] Development of P2X2-purinoceptors in the mouse retina (2009)
  • Author(s): Kaneda, M., Ito, K., Shigematsu, Y., Shimoda, Y
  • Organizer: XXXVIth International Congress of Physiological Sciences(IUPS2009)
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2009-07-28
• [Remarks]
  • URL: http://web.sc.itc.keio.ac.jp/physiol/yuzaki/index.htm
• [Remarks]
  • URL: http://web.sc.itc.keio.ac.jp/physiol/yuzaki/index.htm