Research Project
Grant-in-Aid for Scientific Research (C)
Lipocalin-type prostaglandin D synthase(L-PGDS) could improve the solubility of a poorly water-soluble compound, diazepam(DZP), a major anxiolytic drug in aqueous solutions. The oral administration of DZP/L-PGDS complex significantly extended the duration of loss of righting reflex in mice under a pentobarbital-induced anesthesia as compared with that of DZP in carboxymethylcellulose(CMC). These results demonstrate that L-PGDS is a beneficial delivery vehicle for poorly water-soluble compounds. This novel DDS will facilitate the pharmaceutical and clinical developments of various water-insoluble compounds.
All 2012 2011 2010 2009 Other
All Journal Article (15 results) (of which Peer Reviewed: 15 results) Presentation (64 results) Book (1 results) Remarks (4 results) Patent(Industrial Property Rights) (4 results)
J. Control. Release
Volume: 159巻 Pages: 143-150
Biochem. J.
Volume: 443巻 Pages: 75-84
J. Biochem.
Volume: 151巻 Pages: 335-342
10031166072
J. Neurochem.
Volume: 120巻 Pages: 279-291
Journal of Neurochemistry
Volume: 120 Issue: 2 Pages: 279-291
10.1111/j.1471-4159.2011.07570.x
Journal of Controlled Release
Volume: (印刷中) Issue: 1 Pages: 143-150
10.1016/j.jconrel.2011.12.020
Biochemical Journal
Volume: 443 Issue: 1 Pages: 75-84
10.1042/bj20111889
The Journal of Biochemistry
Volume: 151 Issue: 3 Pages: 335-342
10.1093/jb/mvr140
Netsu Sokutei
Volume: 38 Pages: 165-173
J. Struct. Biol.
Volume: 169巻 Pages: 209-218
SPring-8 research frontiers
Volume: 2009巻 Pages: 9-10
10026301487
FEBS J
Volume: 277巻 Pages: 2683-2695
J.Struct.Biol. 169巻
Pages: 209-218
J.Biol.Chem. 284巻
Pages: 34331-34341
Biochem.Biophys.Res.Commun. 390巻
Pages: 1066-1071
http://www.bioinfo.osakafu-u.ac.jp/~inuit/