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Acceleration of bone regeneration by the injectable electrically polarized hydroxyapatite micro-granules

Research Project

Project/Area Number 21500429
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionTokyo Medical and Dental University (2010-2011)
International University of Health and Welfare (2009)

Principal Investigator

ITO Soichiro  東京医科歯科大学, 歯学部・口腔保健学科, 非常勤講師 (10242190)

Co-Investigator(Kenkyū-buntansha) YAMASHITA Kimihiro  東京医科歯科大学, 生体材料工学研究所, 教授 (70174670)
OU Gi  東京医科歯科大学, 生体材料工学研究所, 助教 (60451944)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsハイドロキシアパタイト / 炭酸アパタイト / 電気分極法 / 多血小板血漿 / 自己血由来多血小板血漿(PRP) / 粉体 / 電気分極処理 / 骨形成促進 / 担体 / 電気分極 / β-TCP / 多血小板血漿(PRP) / 骨再生 / 電荷担体 / イオン伝導
Research Abstract

We have developped a technology for electrical polarization of hydroxyapatite(HA) and carbonated apatite(CA) micro-granules. HA or CA micro-granules with or without electrical polarization/platelet-rich plasma(PRP) composite gel was implanted into femoral condyle of rabbits. In combination with HA, PRP activated osteogenic cells, resulting in enhanced bone formation. This effect was enhanced by electrical polarization treatment in HA micro-granules, however, not in CA micro-granules because they were absorbed rapidly.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (43 results)

All 2012 2011 2010 2009 Other

All Journal Article (27 results) (of which Peer Reviewed: 22 results) Presentation (14 results) Book (2 results)

  • [Journal Article] 分極アパタイト粉体の骨形成促進効果とPRPの担体としての有用性2011

    • Author(s)
      大庭聖子、王巍、伊藤聰一郎、山下仁大
    • Journal Title

      日本生体電気・物理刺激研究会誌

      Volume: 22巻 Pages: 21-26

    • NAID

      40019173971

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 電気分極処理したセラミックス粉体による組織再生促進2011

    • Author(s)
      伊藤聰一郎
    • Journal Title

      整形外科

      Volume: 62巻 Pages: 998-998

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] Electrostatic surface charge acceleration of bone ingrowth of porous hydroxyapatite/β-tricalcium phosphate ceramic2010

    • Author(s)
      Nakamura S., Kobayashi T., Nakamura M., Itoh S., Yamashita K.
    • Journal Title

      J. Biomed. Mater. Res. A.

      Volume: Vol.92 Pages: 267-275

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] バイオセラミックスの電気分極2010

    • Author(s)
      伊藤聰一郎、王巍、山本直輝、山下仁大
    • Journal Title

      日本生体電気・物理刺激研究会誌

      Volume: 24巻 Pages: 17-21

    • NAID

      40017446681

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced bone bonding of the xyapatite/β-tricalcium phosphate composite by electrical polarization in rabbit long bone2010

    • Author(s)
      Sagawa H., Itoh S., Wang W., Yamashita K.
    • Journal Title

      Artif. Organs

      Volume: 34 Pages: 491-497

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Electrical polarization ofβ-tricalcium phosphate ceramics2010

    • Author(s)
      Wang W., Itoh S., Yamamoto N., Okawa A., Nagai A., Yamashita A.
    • Journal Title

      J. Am. Ceram. Soc

      Volume: Vol.93 Pages: 2175-2177

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Electrostatic Surface Charge Boosting Bone Ingrowth of Porous Ceramics2010

    • Author(s)
      Nakamura S., Kobayashi T., Itoh S., Yamashita K.
    • Journal Title

      J. Biomed. Mater. Res. A

      Volume: Vol.92 Pages: 267-275

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enhancement of nerve regeneration along the chitosan nanofiber mesh tube on which electrically polarizedβ-tricalcium phosphate particles are immobilized2010

    • Author(s)
      Wang W., Itoh S., Yamamoto N., Okawa A., Nagai A., Yamashita K.
    • Journal Title

      Acta Biomater

      Volume: Vol.6 Pages: 4027-4033

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 電気分極処理したセラミックス粉体による神経架橋促進2010

    • Author(s)
      伊藤聰一郎
    • Journal Title

      整形外科

      Volume: 61巻 Pages: 1302-1302

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Journal Article] バイオセラミックスの電気分極2010

    • Author(s)
      伊藤聰一郎、王魏、山本直輝、山下仁大
    • Journal Title

      日本生体電気・物理刺激研究会誌

      Volume: 24 Pages: 17-21

    • NAID

      40017446681

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced bone bonding of the hydroxyapatite/β-tricalcium phosphate composite by electrical polarization in rabbit long bone2010

    • Author(s)
      Sagawa H., Itoh S., Wang W., Yamashita K.
    • Journal Title

      Artif.Organs

      Volume: 34 Pages: 491-497

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Electrical polarization of β-tricalcium phosphate ceramics2010

    • Author(s)
      Wang W., Itoh S., Yamamoto N., Okawa A., Nagai A., Yamashita A.
    • Journal Title

      J.Am.Ceram.Soc.

      Volume: 93 Pages: 2175-2177

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Electrostatic Surface Charge Boosting Bone Ingrowth of Porous Ceramics2010

    • Author(s)
      Nakamura S, Kobayashi T, Itoh S, Yamashita K
    • Journal Title

      J.Biomed.Mater.Res.A

      Volume: 92 Pages: 267-275

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhancement of nerve regeneration along the chitosan nanofiber meshtube on which electrically polarized β-tricalcium phosphate particlesare immobilized2010

    • Author(s)
      Wang W., Itoh S., Yamamoto N., Okawa A., Nagai A., Yamashita K.
    • Journal Title

      Acta Biomater.

      Volume: 6 Pages: 4027-4033

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Electrostatic surface charge acceleration of bone ingrowth of porous hydroxyapatite/β-tricalcium phosphate ceramics2010

    • Author(s)
      Nakamura S., Kobayashi T., Nakamura M., Itoh S., Yamashita K.
    • Journal Title

      J.Biomed.Mater.Res.A 92

      Pages: 267-275

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] バイオセラミックスの電気分極による骨接合促進2009

    • Author(s)
      伊藤聰一郎、山下仁大、山本直輝、王巍
    • Journal Title

      化学療法研究所紀要

      Volume: 39巻 Pages: 6-14

    • Related Report
      2011 Final Research Report
  • [Journal Article] Effects of Schwann cell alignment along the oriented electrospun chitosan nanofibers on nerve regeneration2009

    • Author(s)
      Wang W., Itoh S., Konno K., Kikkawa T., Ichinose S, Sakai K., Ohkuma T., Watabe K.
    • Journal Title

      J. Biomed. Mater. Res. 91A

      Volume: Vol.91 Pages: 994-1005

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of enhancement of bone ingrowth into hydroxyapatite ceramics with highly and lowly interconnected pores by Electrical Polarization2009

    • Author(s)
      Wang W., Itoh, S., Tanaka Y., Nagai A., Yamashita K.
    • Journal Title

      Acta Biomater

      Volume: Vol.5 Pages: 3132-3140

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] バイオセラミックスの電気分極による骨接合促進2009

    • Author(s)
      伊藤聰一郎, 山下仁大, 山本直輝, 王巍
    • Journal Title

      化学療法研究所紀要 39

      Pages: 6-14

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 生体注入可能な細胞活性型ゲル材の開発2009

    • Author(s)
      伊藤聰一郎, 秋吉一成, 出村誠
    • Journal Title

      国際医療福祉大学紀要 14

      Pages: 51-52

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Comparison of enhancement of bone ingrowth into hydroxyapatite ceramics with highly and lowly interconnected pores by Electrical Polarization2009

    • Author(s)
      Wang W., Itoh, S.Tanaka Y., Nagai A., Yamashita K.
    • Journal Title

      Acta Biomater. 5

      Pages: 3132-3140

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acceleration of new bone formation by the electrically polarized hydroxyapatite micro-granules/platelet-rich plasma composite

    • Author(s)
      Ohba S., Wang W., Itoh S., Takagi Y., Nagai A., Yamashita K.
    • Journal Title

      Acta Biomater

      Volume: (in press)

    • NAID

      110009358542

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Acceleration of new bone formation by the electrically polarized hydroxyapatite micro-granules/platelet-rich plasma composite

    • Author(s)
      Seiko Ohba, Wei Wang, Soichiro Itoh, Yuzo Takagi, Akiko Nagai, Kimihiro Yamashita
    • Journal Title

      Acta Biomaterialia

      Volume: (In press)

    • NAID

      110009358542

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of Schwann cell alignment along the oriented electrospun chitosan nanofibers on nerve regeneration

    • Author(s)
      Wang W., Itoh S., Konno K., Kikkawa T., Ichinose S, Sakai K., Ohkuma T., Watabe K.
    • Journal Title

      J.Biomed.Mater.Res.A (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced bone bonding of the hydroxyapatite/β-tricalcium phosphate composite by electrical polarization in rabbit long bone

    • Author(s)
      Sagawa H., Itoh S., Wang W., Yamashita K.
    • Journal Title

      Artif.Organs (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Electrical polarization of β-tricalcium phosphate ceramics

    • Author(s)
      Wang W., Itoh S., Yamamoto N., Okawa A., Nagai A., Yamashita A.
    • Journal Title

      J.Am.Ceram.Soc. (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Electrostatic Surface Charge Boosting Bone Ingrowth of Porous Ceramics

    • Author(s)
      Nakamura S, Kobayashi T, Itoh S, Yamashita K.
    • Journal Title

      J.Biomed.Mater.Res.A (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Enhanced effects of electrical polarization to form new bone on hydroxyapatite and availability of platelet-rich plasma as a carrier2012

    • Author(s)
      Itoh S., Ohba S., Wang W., Yamashita K.
    • Organizer
      Orthopedic Research Society 2012 Annual eeting
    • Place of Presentation
      San Francisco
    • Related Report
      2011 Final Research Report
  • [Presentation] PRPあるいはヒアルロン酸を担体として用いた分極処理ハイドロキシアパタイト微粒子の骨形成促進効果比較2012

    • Author(s)
      大庭聖子,王巍,伊藤聰一郎,永井亜希子,山下仁大
    • Organizer
      第39回日本生体電気・物理刺激研究会
    • Place of Presentation
      鹿児島
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Enhanced effects of electrical polarization to form new bone on hydroxyapatite and availability of platelet-rich plasma as a carrier2012

    • Author(s)
      Itoh S., Ohba S., Wang W., Yamashita K.
    • Organizer
      Orthopedic Research Society 2012 Annual Meeting
    • Place of Presentation
      San Francisco
    • Related Report
      2011 Annual Research Report
  • [Presentation] 新たな神経架橋技術の導入-脱細胞化神経と電気分極処理セラミックスによる神経再生の促進-2011

    • Author(s)
      伊藤聰一郎
    • Organizer
      第34回末梢神経を語る会
    • Place of Presentation
      青森
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Enhanced effects of electrical polarization to form new bone on hydroxyapatite micro-granules and availability of platelet-rich plasma as a carrier2011

    • Author(s)
      Seiko Ohba, Wei Wang, Soichiro Itoh, Yuzo Takagi, Kimihiro Yamashita
    • Organizer
      The 1^<st> Tri-University Consortium on Oral Science and Education
    • Place of Presentation
      Bangkok
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 分極ハイドロキシアパタイトの骨形成促進効果とPRPゲルの担体としての有用性2011

    • Author(s)
      大庭聖子,永井亜希子,山下仁大
    • Organizer
      第58回日本歯科理工学会学術講演会
    • Place of Presentation
      郡山
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 分極ハイドロキシアパタイトとPRP混和ゲルの骨形成促進効果2011

    • Author(s)
      大庭聖子,王巍,伊藤聰一郎,山下仁大
    • Organizer
      第38回日本生体電気・物理刺激研究会
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] バイオセラミックスの電気分極2010

    • Author(s)
      伊藤聰一郎、山下仁大、山本直輝、王巍
    • Organizer
      第37回日本生体電気刺激研究会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] 電気分極セラミックス粉体を用いた軟組織の再生医療2010

    • Author(s)
      伊藤聰一郎、王巍、永井亜希子、中村美穂、山下仁大
    • Organizer
      日本セラミックス協会年会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] 電気分極処理したセラミックス粉体による組織再生促進2010

    • Author(s)
      伊藤聰一郎、王巍、永井亜希子、中村美穂、山下仁大
    • Organizer
      第25回日本整形外科学会基礎学術集会
    • Place of Presentation
      京都
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Development of Artificial Bone with Bone-Like Nanostructure using Self-Organization of Hydroxyapatite and Collagen2009

    • Author(s)
      Kikuchi M., Koyama Y., Edamura K., Itoh S., Sotome S., Takakuda K., Tanaka S., Shinomiya K.
    • Organizer
      2nd Asian Biomaterials Congress
    • Place of Presentation
      Singapore
    • Year and Date
      2009-06-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] 分極処理したβ-TCP粉体による神経架橋形成促進2009

    • Author(s)
      伊藤聰一郎、王巍、山下仁大
    • Organizer
      第24回日本整形外科学会基礎学術集会
    • Place of Presentation
      横浜
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] Hydroxyapatite A./Collagen Nanocomposite Materials Mimicking Bone Nanostructure for Bone Regeneration2009

    • Author(s)
      Kikuchi M., Yoshida T., Koyama Y., Sotome S., Itoh S., Takakuda K., Shinomiya K., Edamura K., Tanaka S
    • Organizer
      Irie Indo-Japan Workshop on Nanobiotechnology & Nanodevices
    • Place of Presentation
      Tamil Nadu, India
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] Shinomiya K. Development of Artificial Bone with Bone-Like Nanostructure using Self-Organization of Hydroxyapatite and Collagen2009

    • Author(s)
      Kikuchi M., Koyama Y., Edamura K., Itoh S., Sotome S., Takakuda K., Tanaka S.
    • Organizer
      2nd Asian Biomaterials Congress
    • Place of Presentation
      Singapore
    • Related Report
      2011 Final Research Report
  • [Book] Synthesis of Hydroxyapatite/Collagen Bone-Like Nanocomposite and Its Biological Reactions. Advances in Nanocomposites-Synthesis2011

    • Author(s)
      Kikuchi M., Koyama Y., Edamura K., Irie A., Sotome S., Itoh S., Takakuda K., Shinomiya K., Tanaka S.
    • Total Pages
      14
    • Publisher
      Characterization and Industrial Applications
    • Related Report
      2011 Final Research Report
  • [Book] Advances in Nanocomposites-Synthesis, Characterization and Industrial Applications2011

    • Author(s)
      Kikuchi M., Koyama Y., Edamura K., Irie A., Sotome S., Itoh S., Takakuda K., Shinomiya K., Tanaka S.
    • Total Pages
      14
    • Publisher
      Synthesis of Hydroxyapatite/Collagen Bone-Like Nanocomposite and Its Biological Reactions
    • Related Report
      2011 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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