Acceleration of bone regeneration by the injectable electrically polarized hydroxyapatite micro-granules
| Project/Area Number |
21500429
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Tokyo Medical and Dental University (2010-2011)
International University of Health and Welfare (2009) |
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Principal Investigator |
ITO Soichiro 東京医科歯科大学, 歯学部・口腔保健学科, 非常勤講師 (10242190)
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| Co-Investigator(Kenkyū-buntansha) |
YAMASHITA Kimihiro 東京医科歯科大学, 生体材料工学研究所, 教授 (70174670)
OU Gi 東京医科歯科大学, 生体材料工学研究所, 助教 (60451944)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ハイドロキシアパタイト / 炭酸アパタイト / 電気分極法 / 多血小板血漿 / 自己血由来多血小板血漿(PRP) / 粉体 / 電気分極処理 / 骨形成促進 / 担体 / 電気分極 / β-TCP / 多血小板血漿(PRP) / 骨再生 / 電荷担体 / イオン伝導 |
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| Research Abstract |
We have developped a technology for electrical polarization of hydroxyapatite(HA) and carbonated apatite(CA) micro-granules. HA or CA micro-granules with or without electrical polarization/platelet-rich plasma(PRP) composite gel was implanted into femoral condyle of rabbits. In combination with HA, PRP activated osteogenic cells, resulting in enhanced bone formation. This effect was enhanced by electrical polarization treatment in HA micro-granules, however, not in CA micro-granules because they were absorbed rapidly.
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Report
(4 results)
Research Products
(43 results)
