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The mechanism elucidation of renal rehabilitation in a progressive renal disease

Research Project

Project/Area Number 21500463
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionTohoku University

Principal Investigator

KANAZAWA Masayuki  東北大学, 大学院・医学系研究科, 非常勤講師 (60282050)

Co-Investigator(Kenkyū-buntansha) KOHZUKI Masahiro  東北大学, 大学院・医学系研究科, 教授 (70234698)
ITO Osamu  東北大学, 大学院・医学系研究科, 准教授 (00361072)
佐藤 寿伸  東北大学, 病院, 准教授 (50312583)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords腎臓リハビリテーション / 運動療法 / 組織再生療法 / 慢性腎不全モデルラット / リハビリテーション / 循環器・高血圧 / 細胞・組織 / 動物 / 再生医療 / 腎臓
Research Abstract

We made chronic r enal failure model rats. T he rats were treated by monotherapy and combination therapy of long-term exercise and G-CSF. As the result, monotherapy of long-term exercise and G-CSF showed hypoten sive effect and renal protective effect. Combination therapy of long-term exercise and G-CSF showed hypotensive effect, renal protecti ve effect and decrease urine protein

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (23 results)

All 2012 2011 2010 2009

All Journal Article (6 results) (of which Peer Reviewed: 5 results) Presentation (17 results)

  • [Journal Article] 5/6腎摘除慢性腎不全モデルラットにおける長期的運動とG-CSFの併用療法による腎保護効果2011

    • Author(s)
      須田千尋, 金澤雅之, 姚強, 高島健太, 坂田佳子, 室谷嘉一, 森伸芳, 長坂誠, 海老原覚, 伊藤修, 上月正博
    • Journal Title

      運動療法と物理療法

      Volume: 22 Pages: 78-84

    • NAID

      10029055151

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of estradiol, angiotensin-converting enzyme inhibitor and exercise training on exercise capacity and skeletal muscle in old female rats.2010

    • Author(s)
      Guo Q, Minami N, Mori N, Nagasaka M, Ito O, Kurosawa H, Kanazawa M, Kohzuki M
    • Journal Title

      Clinical Experimaental Hypertension

      Volume: 32 Pages: 1-8

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Atorvastatin upregulates the expression of nitric oxide synthases with Rho-kinase inhibition and Akt activation in the kidney of spontaneously hypertensive rats.2010

    • Author(s)
      Ito D, Ito O, Mori N, Muroya Y, Cao P, Takashima K, Kanazawa M, Kohzuki M
    • Journal Title

      Journal of Hypertension

      Volume: 28 Pages: 2278-2288

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Disability prevention of chronic renal failure : effects of combination therapy with chronic exercise and G-CSF in rats with CRF2009

    • Author(s)
      Suda C, Kanazawa M, Yao Q, Takashima K, Muroya Y, Mori N, Nagasaka M, Ito O, Kurosawa H, Kohzuki M
    • Journal Title

      Proceedings of the 5th World Congress of the International Society of Physical and Rehabilitation Medicine

      Pages: 120-121

    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Journal Article] Combination of chronic exercise and antihypertensive therapy enhances renoprotective effects in rats with renal ablation2009

    • Author(s)
      Lu H, Kanazawa M, Ishida A, Tufescu A, Sasaki Y, Ito O, Kurosawa H, Sato T, Ootaka T, Kohzuki M
    • Journal Title

      Am. J. Hypertens

      Volume: 22 Pages: 1101-1106

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Combination of chronic exercise and antihypertensive therapy enhances renoprotective effects in rats with renal ablation.2009

    • Author(s)
      Lu H, Kanazawa M, Ishida A, Tufescu A, Sasaki Y, Ito O, Kurosawa H, Sato T, Ootaka T, Kohzuki M.
    • Journal Title

      Am.J.Hypertens 22

      Pages: 1101-1106

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 5/6腎摘除慢性腎不全モデルラットにおける、長期的運動とG-CSFの併用療法が及ぼす腎保護効果2012

    • Author(s)
      須田千尋, 金澤雅之, 高島健太, 田村由馬, 坂田佳子, 森信芳, 長坂誠, 海老原覚, 伊藤修, 上月正博
    • Organizer
      第2回日本腎臓リハビリテーション学会学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2012-01-20
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 5/6腎摘除慢性腎不全モデルラットにおける長期的運動とG-CSFの併用療法による腎保護効果2011

    • Author(s)
      須田千尋, 金澤雅之, 姚強, 高島健太, 坂田佳子, 室谷嘉一, 森信芳, 長坂誠, 海老原覚, 伊藤修, 上月正博
    • Organizer
      第34回日本高血圧学会総会
    • Place of Presentation
      宇都宮
    • Year and Date
      2011-10-20
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Combination of chronic exercise and G-CSF protects renal function in chronic renal failure (CRF)rats2011

    • Author(s)
      Suda C, Kanazawa M, Yao Q, Takashima K, Sakata Y, Muroya Y, Mori N, Nagasaka M, Ebihara S, Ito O, Kohzuki M
    • Organizer
      6th World Congress of International Society of Physical Rehabilitation Medicine
    • Place of Presentation
      San Juan, Puerto Rico
    • Year and Date
      2011-06-12
    • Related Report
      2011 Final Research Report
  • [Presentation] Combination of chronic exercise and G-CSF protects renal function in chronic renal failure (CRF) rats2011

    • Author(s)
      Suda C, Kanazawa M, Yao Q, Takashima K, Sakata Y, Muroya Y, Mori N, Nagasaka M, Ebihara S, Ito O, Kohzuki M
    • Organizer
      6^<th> World Congress of International Society of Physical Rehabilitation Medicine
    • Place of Presentation
      サンファン,プエルトリコ
    • Related Report
      2011 Annual Research Report
  • [Presentation] 5/6腎摘除慢性腎不全モデルラットにおける長期的運動とG-CSFの併用療法による腎保護効果2010

    • Author(s)
      須田千尋, 金澤雅之, 高島健太, 坂田佳子, 室谷嘉一, 森伸芳, 長坂誠, 海老原覚, 伊藤修, 上月正博
    • Organizer
      第35回日本運動療法学会大会
    • Place of Presentation
      仙台
    • Year and Date
      2010-07-03
    • Related Report
      2011 Final Research Report
  • [Presentation] 5/6腎摘除慢性腎不全モデルラットにおける運動とolmesartanの腎保護作用に対するカルボニルストレスの役割2010

    • Author(s)
      郭其, 森建文, 金澤雅之, 須田千尋, 伊藤修, 宮田敏男, 伊藤貞嘉, 上月正博
    • Organizer
      第53回日本腎臓学会学術総会
    • Place of Presentation
      神戸
    • Year and Date
      2010-06-17
    • Related Report
      2011 Final Research Report
  • [Presentation] 5/6腎臓摘出慢性腎不全モデルラットにおける運動とolmesartanの腎保護作用に対するカルボニルストレスの役割.2010

    • Author(s)
      郭瑛, 森建文, 金澤雅之, 須田千尋, 伊藤修, 宮田敏男, 伊藤貞嘉, 上月正博
    • Organizer
      第53回日本腎臓学会
    • Place of Presentation
      神戸
    • Year and Date
      2010-06-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] 慢性腎不全ラットのインスリン感受性、交感神経活性と腎障害に対するcilnidipineと長期的運動の併用効果2010

    • Author(s)
      郭其, 張文博, 須田千尋, 金澤雅之, 伊藤修, 森建文, 伊藤貞嘉, 上月正博
    • Organizer
      第53回日本腎臓学会学術総会
    • Place of Presentation
      神戸
    • Year and Date
      2010-06-16
    • Related Report
      2011 Final Research Report
  • [Presentation] 5/6腎摘慢性腎不全ラットの高血圧、インスリン感受性、交感神経活性と腎障害に対するcilnidipineと長期的運動の併用効果2009

    • Author(s)
      郭其, 金澤雅之, 森建文, 張文博, 須田千尋, 伊藤修, 伊藤貞嘉, 上月正博
    • Organizer
      第32回日本高血圧学会総会
    • Place of Presentation
      大津
    • Year and Date
      2009-10-02
    • Related Report
      2011 Final Research Report
  • [Presentation] Disability prevention of chronic renal failure(CRF): Effects of combination therapy with chronic exercise and G-CSF in rats with CRF2009

    • Author(s)
      Suda C, Kanazawa M, Yao Q, Takashima K, Muroya Y, Mori N, Nagasaka M, Ito O, Kurosawa H, Kohzuki M
    • Organizer
      5th World Congress of the International Society of Physical and Rehabilitation Medicine
    • Place of Presentation
      Istanbul, Turkey
    • Year and Date
      2009-06-15
    • Related Report
      2011 Final Research Report
  • [Presentation] Disability prevention of chronic renal failure(CRF) : Effects of combination therapy with chronic exercise and G-CSF in rats with CRF2009

    • Author(s)
      Suda C, Kanazawa M, Yao Q, Takashima K, Muroya Y, Mori N, Nagasaka M, Ito O, Kurosawa H, Kohzuki M
    • Organizer
      5th World Congress of the International Society of Physical and Rehabilitation Medicine
    • Place of Presentation
      イスタンブール,トルコ
    • Year and Date
      2009-06-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] 慢性腎不全モデルラットにおける長期的運動とG-CSFの併用による運動耐容能と腎への効果2009

    • Author(s)
      金澤雅之, 須田千尋, 姚強, 室谷嘉一, 森信芳, 長坂誠, 伊藤修, 黒澤一, 上月正博
    • Organizer
      第46回日本リハビリテーション医学会学術集会
    • Place of Presentation
      静岡
    • Year and Date
      2009-06-06
    • Related Report
      2011 Final Research Report
  • [Presentation] 慢性腎不全モデルラットにおける長期的運動、BCAAと降圧薬による血圧、腎と骨格筋に対する併用効果2009

    • Author(s)
      金澤雅之, 姚強, 須田千尋, 室谷嘉一, 森信芳, 長坂誠, 伊藤修, 黒澤一, 上月正博
    • Organizer
      第46回日本リハビリテーション医学会学術集会
    • Place of Presentation
      静岡
    • Year and Date
      2009-06-06
    • Related Report
      2011 Final Research Report
  • [Presentation] 造血幹細胞移植患者の運動耐容能検査2009

    • Author(s)
      森信芳, 伊藤大亮, 須田千尋, 室谷嘉一, 長坂誠, 伊藤修, 坂田佳子, 室谷智子, 黒澤一, 金澤雅之, 上月正博
    • Organizer
      第46回日本リハビリテーション医学会学術集会
    • Place of Presentation
      静岡
    • Year and Date
      2009-06-06
    • Related Report
      2011 Final Research Report
  • [Presentation] 長期的運動とスタチンの併用効果(その6)高血圧自然発症ラットの血圧と腎NOSへの併用効果2009

    • Author(s)
      伊藤修, 伊藤大亮, 室谷嘉一, 森信芳, 長坂誠, 金澤雅之, 上月正博
    • Organizer
      第46回日本リハビリテーション医学会学術集会
    • Place of Presentation
      静岡
    • Year and Date
      2009-06-06
    • Related Report
      2011 Final Research Report
  • [Presentation] 長期的運動とスタチンの併用効果(その5)高血圧自然発症ラットへのスタチンの単独効果2009

    • Author(s)
      伊藤修, 伊藤大亮, 室谷嘉一, 森信芳, 長坂誠, 金澤雅之, 上月正博
    • Organizer
      第46回日本リハビリテーション医学会学術集会
    • Place of Presentation
      静岡
    • Year and Date
      2009-06-06
    • Related Report
      2011 Final Research Report
  • [Presentation] 慢性腎不全モデルラットにおける長期的運動とG-CSFの併用による運動耐容能と腎への効果2009

    • Author(s)
      金澤雅之, 須田千尋, 姚強, 室谷嘉一, 森信芳, 長坂誠, 伊藤修, 黒澤一, 上月正博
    • Organizer
      第46回 日本リハビリテーション医学会学術集会
    • Place of Presentation
      静岡
    • Year and Date
      2009-06-06
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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