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Investigation of common markers to depressive symptoms and metabolic syndrome-for the prevention and intervention studies

Research Project

Project/Area Number 21500665
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied health science
Research InstitutionKanazawa University (2010-2011)
Fujita Health University (2009)

Principal Investigator

TSUBOI Hirohito  金沢大学, 薬学系, 准教授 (20319338)

Co-Investigator(Kenkyū-buntansha) SAKAKIBARA Hiroyuki  静岡県立大学, 環境科学研究所, 助教 (20403701)
MATSUNAGA Masahiro  生理学研究所, 大脳皮質機能研究系, 特任助教 (00533960)
KANEKO Hirosho  藤田保健衛生大学, 医学部, 教授 (60214467)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords抑うつ / メタボリックシンドローム / 慢性炎症 / 酸化 / 脂肪酸 / サイトカイン / 精神的ストレス / 予防 / うつ
Research Abstract

To investigate the common indicators to metabolic syndrome and depressive symptoms, a cross-sectional study was carried out on women and men in general population. Different serum indicators concerning lipid-or glyco-metabolisms were related to depressive symptoms between male and female population. In addition, an antioxidant appeared to reduce the depressive symptoms. Genotypes in the fatty acid synthase were found to be associated with depressive symptoms. Some common indices to metabolic syndrome and depressive symptoms were presented.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (38 results)

All 2011 2010 2009 Other

All Journal Article (12 results) (of which Peer Reviewed: 10 results) Presentation (24 results) Book (2 results)

  • [Journal Article] Val1483Ile polymorphism in the fatty acid synthase gene was associated with depressive symptoms under the influence of psychological stress2011

    • Author(s)
      Tsuboi H, Sakakibara H(他7名1番目)
    • Journal Title

      Journal of Affective Disorders

      Volume: 134(1-3) Pages: 448-452

    • NAID

      120003141899

    • URL

      http://dx.doi.org/10.1016/j.jad.2011.05.010

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Psychological and physiological responses to odor-evoked autobiographic memory2011

    • Author(s)
      Matsunaga M, Tsuboi H, Kaneko H(他11名5番目)
    • Journal Title

      Activitas Nervosa Superior Rediviva

      Volume: 53(3) Pages: 127-132

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association between perceived happiness levels and peripheral circulating pro-inflammatory cytokine levels in middle-aged adults in Japan2011

    • Author(s)
      Matsunaga M, Tsuboi H, Kaneko H(他9名4番目)
    • Journal Title

      Neuroendocrinology Letters

      Volume: 32(4) Pages: 458-463

    • DOI

      10.1016/j.neures.2011.07.1690

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 冠動脈疾患と社会経済的要因-メカニズムと予防の視点から-2011

    • Author(s)
      坪井宏仁(他4名1番目)
    • Journal Title

      行動医学研究

      Volume: 17(1) Pages: 1-7

    • NAID

      130005003448

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Val1483Ile polymorphism in the fatty acid synthase gene was associated with depressive symptoms under the influence of psychological stress2011

    • Author(s)
      Hirohito Tsuboi
    • Journal Title

      Journal of Affective Disorders

      Volume: 134 Issue: 1-3 Pages: 448-452

    • DOI

      10.1016/j.jad.2011.05.010

    • NAID

      120003141899

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Psychological and physiological responses to odor-evoked autobiographic memory2011

    • Author(s)
      Masahiro Matsunaga
    • Journal Title

      Activitas Nervosa Superior Rediviva

      Volume: 53 Pages: 127-132

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 冠動脈疾患と社会経済的要因 -メカニズムと予防の視点から-2011

    • Author(s)
      坪井宏仁、近藤克則、金子宏、山本績子
    • Journal Title

      行動医学研究

      Volume: 17 Pages: 1-7

    • NAID

      130005003448

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ラット急性ストレス負荷による大腸運動克進に対する中枢オキシトシンの抑制作用2011

    • Author(s)
      金子宏, 松永昌宏, 坪井宏仁, 川西陽子
    • Journal Title

      心身医学

      Volume: 51 Pages: 323-328

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 主観的幸福感に着目した心身相関の新展開2011

    • Author(s)
      松永昌宏, 金子宏, 坪井宏仁, 川西陽子
    • Journal Title

      心身医学

      Volume: 50 Pages: 135-140

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Profiling of serum proteins influenced by warm partner contact in healthy couples2009

    • Author(s)
      Matsunaga M, Tsuboi H(他7名4番目)
    • Journal Title

      NeuroendocrinologyLetters

      Volume: 30(2) Pages: 227-236

    • DOI

      10.1016/j.neures.2009.09.1004

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article]2009

    • Author(s)
      坪井宏仁
    • Journal Title

      ストレス百科事典:うつ(免疫学的側面)(丸善)

      Pages: 155-161

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2009

    • Author(s)
      坪井宏仁
    • Journal Title

      ストレス百科事典:神経・免疫調節(丸善)

      Pages: 1414-1422

    • Related Report
      2009 Annual Research Report
  • [Presentation] 男性における抑うつと血中脂肪酸濃度の関係とその予防因子.酸化・抗酸化の視点から2011

    • Author(s)
      坪井宏仁、渡邊美寿津、小林章雄
    • Organizer
      第27回日本ストレス学会学術総会
    • Place of Presentation
      東京国際交流館(東京都)
    • Year and Date
      2011-11-18
    • Related Report
      2011 Final Research Report
  • [Presentation] 男性における抑うつと血中脂肪酸濃度の関係とその予防因子-酸化・抗酸化の視点から-2011

    • Author(s)
      坪井宏仁
    • Organizer
      第27回日本ストレス学会学術総会
    • Place of Presentation
      東京国際交流館(東京都)
    • Year and Date
      2011-11-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] 当院心療内科受診患者におけるアレキシサイミア傾向を測定する3尺度の検討2011

    • Author(s)
      川西陽子
    • Organizer
      第52回日本心身医学会学術講演会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-06-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] 心拍変動バイオフィードバック療法はうつ状態の改善に有効か?2011

    • Author(s)
      松永昌宏
    • Organizer
      第52回日本心身医学会学術講演会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-06-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] ω3脂肪酸は一般集団におけるうつの予防に有益か?2010

    • Author(s)
      坪井宏仁, 松永昌宏, 金子宏, 他
    • Organizer
      第66回日本心身医学会中部地方会
    • Place of Presentation
      名古屋大学(愛知県)
    • Year and Date
      2010-10-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] 抑うつと酸化・炎症-予防と介入のためのヒント-2010

    • Author(s)
      坪井宏仁
    • Organizer
      日本心理学会第74回大会
    • Place of Presentation
      大阪大学(大阪府)
    • Year and Date
      2010-09-20
    • Related Report
      2011 Final Research Report
  • [Presentation] 抑うつと酸化・炎症-予防と介入のためのヒント2010

    • Author(s)
      坪井宏仁
    • Organizer
      日本心理学会第74回大会
    • Place of Presentation
      大阪大学(大阪府)
    • Year and Date
      2010-09-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] Polymorphisms in fatty acid metabolism-related genes are associated with depressive symptoms2010

    • Author(s)
      suboi H, Sakakibara H, Kaneko H, Matsunaga M(他8名1番目)
    • Organizer
      11th International Congress of Behavioral Medicine
    • Place of Presentation
      GrandHyatt Washington(USA)
    • Year and Date
      2010-08-07
    • Related Report
      2011 Final Research Report
  • [Presentation] Va1148311e polymorphism in the fatty acid synthase gene was associated with depressive symptoms under the influence of psychological stress2010

    • Author(s)
      Hirohito Tsuboi, Masahiro Matsunaga, Hiroshi Kaneko, et.al
    • Organizer
      11th International Congress of Behavioral Medicine
    • Place of Presentation
      Grand Hyatt Washington(USA)
    • Year and Date
      2010-08-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] 主観的幸福感/特性不安と脳機能・気分状態・血中物質との関連2010

    • Author(s)
      松永昌宏, 金子宏, 坪井宏仁, 他
    • Organizer
      第51回日本心身医学会総会
    • Place of Presentation
      東北大学(宮城県)
    • Year and Date
      2010-06-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] ラット急性ストレス負荷による大腸運動亢進に対する中枢オキシトシンの抑制作用2010

    • Author(s)
      金子宏, 松永昌宏, 坪井宏仁, 他
    • Organizer
      第51回日本心身医学会総会
    • Place of Presentation
      東北大学(宮城県)
    • Year and Date
      2010-06-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] 脂肪酸と抑うつ症状に関する横断的研究2010

    • Author(s)
      坪井宏仁、松永昌宏、金子宏(他5名1番目)
    • Organizer
      第51回日本心身医学会学術総会
    • Place of Presentation
      仙台国際センター(宮城県)
    • Year and Date
      2010-06-26
    • Related Report
      2011 Final Research Report
  • [Presentation] 脂肪酸と抑うつ症状に関する横断的研究2010

    • Author(s)
      坪井宏仁, 松永昌宏, 金子宏, 他
    • Organizer
      第51回日本心身医学会総会
    • Place of Presentation
      策北大学(宮城県)
    • Year and Date
      2010-06-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] ドリンク摂取時の胃生理機能、血中ホルモン濃度変化に対する様々なストレス負荷の影響2010

    • Author(s)
      松永昌宏, 金子宏, 坪井宏仁, 他
    • Organizer
      第51回日本心身医学会総会
    • Place of Presentation
      東北大学(宮城県)
    • Year and Date
      2010-06-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 一般集団における抑うつ症状と脂肪酸代謝の関連性について2010

    • Author(s)
      坪井宏仁, 松永昌宏, 金子宏, 他
    • Organizer
      第7回日本うつ病学会総会
    • Place of Presentation
      石川県立音楽堂(石川県)
    • Year and Date
      2010-06-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] 一般集団における抑うつ症状と脂肪酸代謝の関連性について2010

    • Author(s)
      坪井宏仁、榊原啓之、松永昌宏、金子宏(他8名1番目)
    • Organizer
      第7回日本うつ病学会
    • Place of Presentation
      石川県立音楽堂(石川県)
    • Year and Date
      2010-06-11
    • Related Report
      2011 Final Research Report
  • [Presentation] 男性における抑うつ度と各種脂肪酸血中濃度との関連性について2010

    • Author(s)
      坪井宏仁,金子宏,松永昌宏(他6名1番目)
    • Organizer
      第64回日本心身医学会中部地方会
    • Place of Presentation
      名古屋大学医学部鶴友会館(愛知県)
    • Year and Date
      2010-05-15
    • Related Report
      2011 Final Research Report
  • [Presentation] 抑うつ状態を判定するためのバイオマーカーの探索2009

    • Author(s)
      加藤綾子、坪井宏仁(他5名4番目)
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2009-12-10
    • Related Report
      2011 Final Research Report
  • [Presentation] Some gene polymorphisms associated with lifestyle-related diseases may affect depressive symptoms2009

    • Author(s)
      Tsuboi H, Sakakibara H, MatsunagaM, Kaneko H(他12名1番目)
    • Organizer
      20th WorldCongress on Psychosomatic Medicine
    • Place of Presentation
      Ingresso Centro Congressi(Italy)
    • Year and Date
      2009-09-24
    • Related Report
      2011 Final Research Report
  • [Presentation] Some gene polymorphisms associated with lifestyle-related diseases may affect depressive symptoms2009

    • Author(s)
      坪井宏仁
    • Organizer
      20th World Congress on Psychosomatic Medicine
    • Place of Presentation
      トリノ(イタリア)
    • Year and Date
      2009-09-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] 主観的幸福感に関連する血清タンパク質同定の試み2009

    • Author(s)
      松永昌宏,坪井宏仁,金子宏(他8名3番目)
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2009-09-17
    • Related Report
      2011 Final Research Report
  • [Presentation] 主観的幸福感に関連する血清タンパク質同定の試み2009

    • Author(s)
      松永昌宏
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2009-09-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] 一般集団における起床後のHPA軸の変化・酸化・口腔内免疫と抑うつとの関連性2009

    • Author(s)
      坪井宏仁,松永昌宏,金子宏,(他7名1番目)
    • Organizer
      第50回日本心身医学会学術総会
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Year and Date
      2009-06-06
    • Related Report
      2011 Final Research Report
  • [Presentation] 日常のストレス下での抑うつ感および満足感の5-HTT遺伝子多型による違い2009

    • Author(s)
      坪井宏仁,松永昌宏,金子宏(他13名1番目)
    • Organizer
      第62回日本心身医学会中部地方会
    • Place of Presentation
      名古屋市立大学(愛知県)
    • Year and Date
      2009-04-18
    • Related Report
      2011 Final Research Report
  • [Book] うつ(免疫学的側面)ストレス百科事典2009

    • Author(s)
      坪井宏仁
    • Publisher
      丸善
    • Related Report
      2011 Final Research Report
  • [Book] 神経・免疫調節ストレス百科事典

    • Author(s)
      坪井宏仁
    • Publisher
      丸善
    • Related Report
      2011 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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