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Study on the effectiveness of diet or exercise therapy for young obese males in terms of insulin resistance.

Research Project

Project/Area Number 21500682
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied health science
Research InstitutionNagoya University

Principal Investigator

KOIKE Teruhiko  名古屋大学, 総合保健体育科学センター, 准教授 (90262906)

Co-Investigator(Kenkyū-buntansha) OSHIDA Yoshiharu  名古屋大学, 総合保健体育科学センター, 教授 (10169295)
AKIMA Hiroshi  名古屋大学, 総合保健体育科学センター, 准教授 (40292841)
ISHIDA Koji  名古屋大学, 総合保健体育科学センター, 教授 (50193321)
KATAYAMA Keisho  名古屋大学, 総合保健体育科学センター, 准教授 (40343214)
ENOKI Hiromi  愛知淑徳大学, 健康医療科学部, 准教授 (90524497)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords生活習慣病 / インスリン抵抗性 / カロリー制限 / 運動
Research Abstract

Appropriate lifestyle choices when persons are young and healthy are critical for the maintenance of life-long health in an ageing society. In the present study, diet and exercise habits surveyed among young obese males showed various characteristics. However, each individual had different lifestyle-related problems, which would demand individualized measures. Caloric restriction with exercise for 4 weeks strongly suppressed insulin resistance and chronic inflammatory status, but the effects were weaker by caloric restriction alone, indicating importance of exercise to enhance metabolic benefits with diet therapy.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (41 results)

All 2012 2011 2010 2009 Other

All Journal Article (23 results) (of which Peer Reviewed: 18 results) Presentation (12 results) Book (6 results)

  • [Journal Article] 押田芳治BMI30kg/m2以上の若年肥満男性の食事および身体活動の特徴2012

    • Author(s)
      夏目有紀枝、小池晃彦、押田芳治
    • Journal Title

      総合保健体育科学

    • Related Report
      2011 Final Research Report
  • [Journal Article] Effects of angiotensin II AT1 receptor inhibition and exercise training on insulin action in rats on high-fat diet2012

    • Author(s)
      Z.Wang, T.Koike, P.Li, H.Jiang, Y.Natsume, L.Mu, T.Chen, Y.Oshida
    • Journal Title

      Life Sciences

      Volume: 90 Issue: 9-10 Pages: 322-327

    • DOI

      10.1016/j.lfs.2011.11.015

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acute treatment with candesartan cilexetil, an angiotensin II type 1 receptor blocker, improves insulin sensitivity in high-fructose diet-fedrats2012

    • Author(s)
      R.Li, T.Koike, H.Jiang, Z.Wang, Y.Kawata, Y.Oshida
    • Journal Title

      Horm Metab Res

      Volume: 44 Issue: 04 Pages: 286-290

    • DOI

      10.1055/s-0032-1304321

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] BMI30kg/m^2以上の若年肥満男性の食事および身体活動の特徴2012

    • Author(s)
      夏目有紀枝、小池晃彦、押田芳治
    • Journal Title

      総合保健体育科学

      Volume: 35(印刷中)(in press)

    • Related Report
      2011 Annual Research Report
  • [Journal Article] サルコペニアの今2011

    • Author(s)
      小池晃彦、秋間広、柳本有二、片山敬章、石田浩司、坂崎貴彦、夏目有紀枝、押田芳治
    • Journal Title

      J. Physical Medicine

      Volume: 22(3) Pages: 307-314

    • Related Report
      2011 Final Research Report
  • [Journal Article] The Effect of Intense Interval Cycle-training on Unloading-Induced Dysfunction and Atrophy in the Human Calf Muscle2011

    • Author(s)
      N.Hotta, K.Ishida, K.Sato, T.Koike, K.Katayama, H.Akima
    • Journal Title

      Journal of PHYSIOLOGICAL ANTHROPOLOGY

      Volume: 30 Issue: 1 Pages: 29-35

    • DOI

      10.2114/jpa2.30.29

    • NAID

      10027419031

    • ISSN
      1880-6791, 1880-6805
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypoxia augments muscle sympathetic neural response to leg cycling2011

    • Author(s)
      Katayama K, Ishida K, Iwamoto E, Iemitsu M, Koike T, Saito M
    • Journal Title

      Am J Physiol Regl Integr Comp Physiol

      Volume: 301 Issue: 2 Pages: R456-R464

    • DOI

      10.1152/ajpregu.00119.2011

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] サルコペニアの今:サルコペニアの対策、予防と治療2011

    • Author(s)
      小池晃彦、秋間広、柳本有二、片山敬章、石田浩司、坂崎貴彦、夏目有紀枝、押田芳治
    • Journal Title

      運動・物理療法(J.Physical Medicine)

      Volume: 22 Pages: 307-314

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 若年肥満学生の食環境と栄養素摂取状況の関連について2010

    • Author(s)
      榎裕美、葛谷雅文、押田芳治、小池晃彦
    • Journal Title

      日本未病システム学会

      Volume: 16(2) Pages: 297-299

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Journal Article] Alanine aminotransferase and gamma-glutamyltransferase as markers for elevated insulin resistance-associated metabolic abnormalities in obese Japanese men younger than 30 years of age2010

    • Author(s)
      T.Koike, M.Miyamoto, Y.Oshida
    • Journal Title

      Obesity Research & Clinical Practice

      Volume: 4

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Combined effect of short-term calorie restriction and exercise on insulin action in normal rats2010

    • Author(s)
      H.Jiang, T.Koike, P.Li, Z.Wang, Y.Kawata, Y.Oshida
    • Journal Title

      Horm Metab Res

      Volume: 42 Pages: 950-954

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Waist circumference is positively associated with insulin resistance but not with fasting blood glucose among moderately to highly obese young Japanese men2009

    • Author(s)
      T.Koike, M.Miyamoto, Y.Oshida
    • Journal Title

      Obesity Research & Clinical Practice

      Volume: 3 Pages: 109-114

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cycle ergometer exercise to counteract muscle atrophy during unilateral lower limb suspension.2009

    • Author(s)
      H.Akima, N. Hotta, K. Sato, K. Ishida, T.Koike.
    • Journal Title

      Aviat Space Environ Med

      Volume: 80(7) Pages: 652-656

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The adaptive responses in several mediators linked with hypertrophy and atrophy of skeletal muscle after lower limb unloading in humans.2009

    • Author(s)
      K.Sakuma, W. Kohei, N. Norio, T. Koike, K. Ishida, K. Katayama, H. Akima.
    • Journal Title

      Acta Physiologica

      Volume: 197 Pages: 151-159

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Waist circumference is positively associated with insulin resistance but not with fasting blood glucose among moderately to highly obese young Japanese men

    • Author(s)
      T. Koike, M. Miyamoto, Y. Oshida
    • Journal Title

      Obesity Research & Clinical Practice

      Volume: 3 Pages: 109-114

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cycle ergometer exercise to counteract muscle atrophy during unilateral lower limb suspension

    • Author(s)
      H. Akima, N. Hotta, K. Sato, K. Ishida, T. Koike, K. Katayama
    • Journal Title

      Aviat Space Environ Med

      Volume: 80(7) Pages: 652-656

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The adaptive responses in several mediators linked with hypertrophy and atrophy of skeletal muscle after lower limb unloading in humans

    • Author(s)
      K. Sakuma, W. Kohei, N. Hotta, T. Koike, K. Ishida, K. Katayama, H. Akima.
    • Journal Title

      Acta Physiologica

      Volume: 197 Pages: 151-159

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Alanine aminotransferase and gamma-glutamyl transferase as markers for elevated insulin resistance. associated metabolic abnormalities in obese Japanese men younger than 30 years of age

    • Author(s)
      T. Koike, M. Miyamoto, Y. Oshida.
    • Journal Title

      Obesity Research & Clinical Practice

      Volume: 4 Pages: 73-79

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Combined effect of short-term calorie restriction and exercise on insulin action in normal rats

    • Author(s)
      H. Jiang, T. Koike, P. Li, Z. Wang, Y. Kawata, Y. Oshida
    • Journal Title

      Horm Metab Res

      Volume: 42(13) Pages: 950-954

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The effect of intense interval cycle-training on unloading-induced dysfunction and atrophy in the human calf muscle

    • Author(s)
      N. Hotta, K. Ishida, K. Sato, T. Koike, K. Katayama, H. Akima.
    • Journal Title

      J Physiol Anthropol

      Volume: 30(1) Pages: 29-35

    • NAID

      10027419031

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hypoxia augments muscle sympathetic neural response to leg cycling

    • Author(s)
      K. Katayama, K. Ishida, E. Iwamoto, M. Iemitsu, T. Koike, M. Saito.
    • Journal Title

      J Am J Physiol Regul Integr Comp Physiol

      Volume: 301 Pages: 456-464

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of angiotensin II AT1 receptor inhibition and exercise training on insulin action in rats on high-fat diet

    • Author(s)
      Z. Wang, T. Koike, P. Li, H. Jiang, Y. Natsume, L. Mu, T. Chen, Y. Oshida
    • Journal Title

      Life Sciences

      Volume: 90 Pages: 322-327

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Acute treatment with candesartan cilexetil, an angiotensin II type 1 receptor blocker, improves insulin sensitivity in high-fructose diet-fed rats

    • Author(s)
      P. Li, T. Koike, H. Jiang, Z. Wang, Y. Kawata, Y. Oshida.
    • Journal Title

      Horm Metab Res

      Volume: 44(4) Pages: 286-290

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] 標準体重男性で"腹八分"と運動はインスリン抵抗性と慢性炎症を改善する2011

    • Author(s)
      小池晃彦、片山敬章、夏目有紀枝、岩本えりか、石田浩司、押田芳治
    • Organizer
      第49回全国大学保健管理研究集会
    • Place of Presentation
      下関
    • Year and Date
      2011-11-09
    • Related Report
      2011 Final Research Report
  • [Presentation] 標準体重男性で"腹八分"と運動はインスリン抵抗性と慢性炎症を改善する2011

    • Author(s)
      小池晃彦、片山敬章、夏目有紀枝、岩本えりか、石田浩司、押田芳治
    • Organizer
      第49回全国大学保健管理研究集会
    • Place of Presentation
      海峡メッセ下関
    • Year and Date
      2011-11-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] カロリー制限と運動がインスリン感受性に及ぼす影響2011

    • Author(s)
      姜海英、小池晃彦、王忠華、夏目有紀枝、木蘭、陳塔娜、押田芳治
    • Organizer
      第84回日本糖尿病学会中部地方会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-22
    • Related Report
      2011 Final Research Report
  • [Presentation] カロリー制限と運動がインスリン感受性に及ぼす影響2011

    • Author(s)
      姜海英、小池晃彦、王忠華、夏目有紀枝、木蘭、陳塔郷、押田芳治
    • Organizer
      第84回日本糖尿病学会中部地方会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2011-10-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] 若年肥満男性の食環境と栄養素摂取状況の関連について2010

    • Author(s)
      榎裕美、葛谷雅文、押田芳治、小池晃彦
    • Organizer
      第17回日本未病システム学会
    • Place of Presentation
      沖縄
    • Year and Date
      2010-11-13
    • Related Report
      2011 Final Research Report
  • [Presentation] 若年肥満男性の食環境と栄養素摂取状況の関連について2010

    • Author(s)
      榎裕美、葛谷雅文、押田芳治、小池晃彦
    • Organizer
      第17回日本未病システム学会
    • Place of Presentation
      沖縄県男女共同参画センター「てぃるる」
    • Year and Date
      2010-11-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] インスリン感受性に及ぼすカロリー制限と運動の影響2010

    • Author(s)
      姜海英、小池晃彦、王忠華、筒井秀世、押田芳治
    • Organizer
      第53回日本糖尿病学会大会
    • Place of Presentation
      岡山
    • Year and Date
      2010-05-27
    • Related Report
      2011 Final Research Report
  • [Presentation] インスリン感受性に及ぼすカロリー制限と運動の影響2010

    • Author(s)
      姜海英、小池晃彦、王忠華、筒井秀世、押田芳治
    • Organizer
      第53回日本糖尿病学会大会
    • Place of Presentation
      岡山デジタルミュージアム
    • Year and Date
      2010-05-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] 高齢女性の体重支持指数(WBI)からみた踵骨骨強度と体力測定値との関連2009

    • Author(s)
      坂崎貴彦、柳本有二、秋山眞視、小池晃彦、押田芳治
    • Organizer
      第64回日本体力医学会
    • Place of Presentation
      新潟
    • Year and Date
      2009-09-18
    • Related Report
      2011 Final Research Report
  • [Presentation] 高齢女性の体重支持指数(WBI)からみた踵骨骨強度と体力測定値との関連2009

    • Author(s)
      坂崎貴彦, 柳本有二, 秋山眞視, 小池晃彦, 押田芳治
    • Organizer
      第64回日本体力医学会
    • Place of Presentation
      新潟コンベンションセンター
    • Year and Date
      2009-09-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] ARBの急性投与により、高果糖誘発インスリン抵抗性が改善する2009

    • Author(s)
      李萍、小池晃彦、川田裕樹、姜海英、王忠華、押田芳治
    • Organizer
      第52回日本糖尿病学会大会
    • Place of Presentation
      大阪
    • Year and Date
      2009-05-22
    • Related Report
      2011 Final Research Report
  • [Presentation] ARBの急性投与により、高果糖誘発インスリン抵抗性が改善する2009

    • Author(s)
      李萍、小池晃彦、川田裕樹、姜海英、王忠華、押田芳治
    • Organizer
      第52回日本糖尿病学会大会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2009-05-22
    • Related Report
      2009 Annual Research Report
  • [Book] 2011 Identification of hemodialysis patients' physical and psychosocial problems using the international classification of functioning, disability and health(ICF). 59-70 : Hemodialysis-Different Aspects2011

    • Author(s)
      H. Tsutsui, T. Koike, Y. Oshida.
    • Publisher
      InTech
    • Related Report
      2011 Final Research Report
  • [Book] Identification of hemodialysis patients' physical and psychosocial problems using the international classification of functioning, disability and health (ICF). : Hemodialysis-Different Aspects2011

    • Author(s)
      H.Tsutsui, T.Koike, Y.Oshida
    • Publisher
      InTech
    • Related Report
      2011 Annual Research Report
  • [Book] 糖尿病運動療法のエビデンス288-289:糖尿病ナビゲーター(門脇孝編)2010

    • Author(s)
      小池晃彦、押田芳治
    • Publisher
      メディカルレビュー社
    • Related Report
      2011 Final Research Report
  • [Book] 運動療法41-49 :科学的根拠に基づく糖尿病診療ガイドライン2010

    • Author(s)
      押田芳治、小池晃彦
    • Publisher
      南江堂
    • Related Report
      2011 Final Research Report
  • [Book] 糖尿病運動療法のエビデンス:糖尿病ナビゲーター2010

    • Author(s)
      小池晃彦、押田芳治
    • Publisher
      メディカルレビュー社
    • Related Report
      2010 Annual Research Report
  • [Book] 運動療法:科学的根拠に基づく糖尿病診療ガイドライン2010(日本糖尿病学会編)2010

    • Author(s)
      押田芳治、小池晃彦
    • Publisher
      南江堂
    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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