| Project/Area Number |
21500798
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Matsumoto University |
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Principal Investigator |
YAMADA Kazuya 松本大学, 大学院・健康科学研究科, 教授 (20263238)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | インスリン / 高炭水化物食 / SHARP / 時計遺伝子 / 血糖調節 / 食品成分 / 糖尿病 / SHARP-2 / ゲニステイン / ダイゼイン / NF-kB |
|---|
| Research Abstract |
Both SHARP-1 and SHARP-2 are high carbohydrate diet-induced transcription factors. We assume that these factors are involved in the lowering of blood glucose level via a suppression of hepatic gluconeogenesis by insulin. In this study, a mechanism(s) controlling expressions of these genes was analyzed. As the results, we showed that insulin induced the level of SHARP-1 mRNA, gene expression of SHARP-1 but not SHARP-2 was regulated by AMP-activated protei kinase, and that genistein, a soybean isoflavone, and EGCG, a green tea polyphenol, rapidly induced these gene expressions as well as insulin.
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