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Solid-state Reaction in Organic Inclusion Crystal Investigated by Powder X-ray Diffraction Analysis

Research Project

Project/Area Number 21550008
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Physical chemistry
Research InstitutionTokyo Institute of Technology

Principal Investigator

UEKUSA Hidehiro  東京工業大学, 大学院・理工学研究科, 准教授 (60242260)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords結晶構造 / 粉末結晶解析 / 結晶構造解析 / 粉末X線結晶解析 / 光固相反応 / 脱水転移 / 医薬品原薬 / 水和物 / 紫外線吸収剤 / 熱測定
Research Abstract

The color of thermal paper turns yellow by UV light irradiation due to decomposition of color pigment. In order to resolve this low light fastness problem, a series of cinnamic acid esters that have UV light absorbing function were synthesized as new group of color developing compound. The difference of the light fastness is attributed to the molecular configuration difference in the crystalline state, which leads crystalline state molecular dimerization reaction by UV light and produces low UV absorbing compound.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (29 results)

All 2012 2011 2010 2009 Other

All Journal Article (16 results) (of which Peer Reviewed: 15 results) Presentation (12 results) Remarks (1 results)

  • [Journal Article] 新規顕色剤を用いた高耐光性感熱記録紙の実現2012

    • Author(s)
      兒玉智史, 藤井博, 佐藤真一, 植草秀裕
    • Journal Title

      日本画像学会誌

      Volume: 51(2) Pages: 139-146

    • NAID

      130004800832

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reversible Color Switching of an Organic Crystal Induced by Organic Solvent Vapors2011

    • Author(s)
      K. Fujii, A. Sakon, A. Sekine, and H. Uekusa
    • Journal Title

      Crystal Growth & Design

      Volume: 11 Pages: 4305-4308

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Metastable polymorphic form of isopropylbenzophenone derivative directly obtained by the solid-state photoreaction investigated by ab initio powder X-ray diffraction analysis2011

    • Author(s)
      K. Fujii, H. Uekusa, M. Fukano, H. Koshima
    • Journal Title

      CrystEngComm

      Volume: 13 Pages: 3197-3201

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] In situobservation and mechanistic elucidation of metastable colored species in crystalline state photochromism of trans-biindenylidenedione2011

    • Author(s)
      K. Fujii, K. Aruga, A. Sekine, H. Uekusa, K. Sohno, K. Tanaka
    • Journal Title

      CrystEngComm

      Volume: 13 Pages: 731-733

    • NAID

      120005686960

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reversible Color Switching of an Organic Crystal Induced by Organic Solvent Vapors2011

    • Author(s)
      K.Fujii, A.Sakon, A.Sekine, H.Uekusa
    • Journal Title

      Ctyst.Growth Des.

      Volume: 11 Issue: 10 Pages: 4305-4308

    • DOI

      10.1021/cg2010437

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In situ observation and mechanistic elucidation of metastable colored species in crystalline state photochromism of trans-biindenylidenedione2011

    • Author(s)
      K.Fujii, K.Aruga, A.Sekine, H.Uekusa, K.Sohno, K.Tanaka
    • Journal Title

      CrystEngComm

      Volume: 13 Issue: 3 Pages: 731-733

    • DOI

      10.1039/c0ce00642d

    • NAID

      120005686960

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selective transformation pathways between crystalline forms of an organic material established from powder X-ray diffraction analysis2010

    • Author(s)
      K. Fujii, Y. Ashida, H. Uekusa, F. Guo, K. Harris
    • Journal Title

      Chem. Commun

      Volume: 46 Pages: 4264-4266

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Physicochemical Understanding of Polymorphism and Solid-State Dehydration/Rehydration Processes for the Pharmaceutical Material Acrinol, by Ab Initio Powder X-ray Diffraction Analysis and other Techniques2010

    • Author(s)
      K. Fujii, H. Uekusa, N. Itoda, G. Hasegawa, E. Yonemochi, K. Terada, Z. Pan, K. Harris
    • Journal Title

      J. Phys. Chem. C

      Volume: 114 Pages: 580-586

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Polymorphic crystal approach to changing the emission of [AuCI(PPh3)2], analyzed by direct observation of photoexcited structures by X-ray photocrystallography2010

    • Author(s)
      M.Hoshino, H.Uekusa, et al.
    • Journal Title

      Inorg.Chem.

      Volume: 49 Pages: 7257-7265

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selective transformation pathways between crystalline forms of an organic material established from powder X-ray diffraction analysis.2010

    • Author(s)
      KFujii, H.Uekusa, et al.
    • Journal Title

      Chem.Comm.

      Volume: 46 Pages: 4264-4266

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Physicochemical Understanding of Polymorphism and Solid-State Dehydration/Rehydration Processes for the Pharmaceutical Material Acrinol, by Ab Initio Powder X-ray Diffraction Analysis and other Techniques2010

    • Author(s)
      KFujii, H.Uekusa, et al.
    • Journal Title

      J.Phys.Chem.C.

      Volume: 114 Pages: 580-586

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vapor Induced Crystalline Transformation Investigated by ab initio Powder X-ray Diffraction Analysis2009

    • Author(s)
      K. Fujii, Y. Ashida, H. Uekusa, S. Hirano, S. Toyota, F. Toda, Z. Pan, K. Harris
    • Journal Title

      Cryst. Growth Des

      Volume: 9 Pages: 1201-1207

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reevaluation of solubility of tolbutamide and polymorphic transformation from Form I to unknown crystal form.2009

    • Author(s)
      G.Hasegawa, H.Uekusa, et al.
    • Journal Title

      Int.J.Pharm. 369

      Pages: 12-18

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vapor Induced Crystalline Transformation Investigated by abinitio Powder X-ray Diffraction Analysis.2009

    • Author(s)
      K.Fujii, H.Uekusa, et al.
    • Journal Title

      Cryst.Growth Des. 9

      Pages: 1201-1207

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Performance of the micro-PIC gaseous area detector in smallangle X-ray scattering experiments.2009

    • Author(s)
      K.Hattori, H.Uekusa, et al.
    • Journal Title

      J.Synchrotron Radiat. 16

      Pages: 231-236

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2009

    • Author(s)
      中井泉・泉富士夫編蓍(分担)
    • Journal Title

      粉末X線解析の実際(第二版)第12章「粉末結晶構造解析」(朝倉書店)

      Pages: 191-201

    • Related Report
      2009 Annual Research Report
  • [Presentation] 感熱紙用新規耐光性顕色剤の光照射に対する挙動2011

    • Author(s)
      兒玉智史, 他
    • Organizer
      平成23年度日本結晶学会年会
    • Place of Presentation
      札幌
    • Year and Date
      2011-11-24
    • Related Report
      2011 Final Research Report
  • [Presentation] Behaviors of Novel Cinnamic Amide Developers Against Photoirradiation2011

    • Author(s)
      S. Kodama et al
    • Organizer
      IUCr2011
    • Place of Presentation
      Madrid
    • Year and Date
      2011-08-24
    • Related Report
      2011 Final Research Report
  • [Presentation] Pseudo-polymorphic transition of pharmaceutical crystals revealed by SDPD method2011

    • Author(s)
      H. Uekusa et al
    • Organizer
      IUCr2011
    • Place of Presentation
      Madrid
    • Year and Date
      2011-08-23
    • Related Report
      2011 Final Research Report
  • [Presentation] Behaviors of Novel Cinnamic Amide Developers Against Photoirradiation2011

    • Author(s)
      Satoshi Kodama, Hiroshi Fujii, Hidehiro Uekusa
    • Organizer
      International Conference on the Chemistry of Solid-state
    • Place of Presentation
      バンガロール(インド)
    • Year and Date
      2011-06-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] 感熱紙用新規高耐光性顕色剤の開発研究2011

    • Author(s)
      兒玉智史, 他
    • Organizer
      第107回日本画像学会研究討論会
    • Place of Presentation
      東京
    • Year and Date
      2011-06-06
    • Related Report
      2011 Final Research Report
  • [Presentation] Development of High Lightfast Developer for Thermal Papers2010

    • Author(s)
      S. Kodama et al
    • Organizer
      PACIFICHEM2010
    • Place of Presentation
      Hawaii
    • Year and Date
      2010-12-16
    • Related Report
      2011 Final Research Report
  • [Presentation] Structural rearrangement of organic crystals in polymorphic transition investigated by ab initiostructure determination from powder diffraction data2010

    • Author(s)
      H. Uekusa
    • Organizer
      PACIFICHEM2010
    • Place of Presentation
      Hawaii
    • Year and Date
      2010-12-16
    • Related Report
      2011 Final Research Report
  • [Presentation] Polymorphic transition of pharmaceutical crystals investigated by Structure Determination from Powder Diffraction data2010

    • Author(s)
      H. Ueksua et al
    • Organizer
      ICMN2010
    • Place of Presentation
      Bandung
    • Year and Date
      2010-11-24
    • Related Report
      2011 Final Research Report
  • [Presentation] Polymorphic transition of pharmaceutical crystals investigated by Structure Determination from Powder Diffraction data2010

    • Author(s)
      Hidehiro Uekusa
    • Organizer
      INTERNATIONAL CONFERENCE ON MATHEMATICS AND NATURAL SCIENCES
    • Place of Presentation
      Bandung Institute of Technology, Indonesia
    • Year and Date
      2010-11-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] Pharmaceutical Polymorphs and their Phase Transitions Investigated by Ab Initio Structure Determination from Powder Diffraction Data2010

    • Author(s)
      H. Uekusa et al
    • Organizer
      AsCA
    • Place of Presentation
      Busan
    • Year and Date
      2010-11-02
    • Related Report
      2011 Final Research Report
  • [Presentation] 粉末X線結晶解析による医薬品化合物の構造と物性2009

    • Author(s)
      植草秀裕
    • Organizer
      日本結晶学会シンポジウム講演
    • Place of Presentation
      関西学院大学・兵庫県
    • Year and Date
      2009-12-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] 粉末X線結晶解析による医薬品化合物の構造と物性2009

    • Author(s)
      植草秀裕
    • Organizer
      平成21年度日本結晶学会年会
    • Place of Presentation
      大阪
    • Year and Date
      2009-12-05
    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.cms.titech.ac.jp/~uekusa/

    • Related Report
      2011 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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