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Chemical Properties of Pt(II) Complexes Effective for Cisplatin Resistance Cancer and Its Application to Anticancer Drugs

Research Project

Project/Area Number 21550058
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Inorganic chemistry
Research InstitutionKanazawa University

Principal Investigator

ODANI Akira  金沢大学, 薬学系, 教授 (60143913)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords白金抗がん剤 / シスプラチン / 耐性 / 腎毒性 / イオン / プロテアソーム活性阻害 / 白金錯体 / シスプラチン耐性 / 抗がん作用 / プレテアソーム阻害 / パラジウム錯体 / 芳香環スタッキング / ヒドロキシアパタイト吸着 / プロテアソーム阻害 / オクタノール / 水分配比
Research Abstract

The weak points in cisplatin type Pt(II) anticancer drugs are(1) lower activity for cisplatin resistance cancer,(2) high nephrotoxicity, however, these points were solved by the introduction of the ionic form to Pt(II) complexes. The cationic Pt(II) complexes involving aromatic ring stacking, which was shown in cisplatin coordinated DNA-HMG protein adduct, showed the proteasome inhibition as a new anticancer mechanism. Both the cationic and the anionic Pt(II) complexes exhibited the excellent anticancer effect and are considered to be possible to develop the clinical anticancer drugs.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (39 results)

All 2012 2011 2010 2009 Other

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (27 results) Remarks (2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Metal-based drugs開発研究の最前線2012

    • Author(s)
      小谷明, 桜井弘
    • Journal Title

      Yakugaku Zasshi

      Volume: 132(2) Pages: 251-251

    • NAID

      130001872017

    • URL

      https://www.jstage.jst.go.jp/article/yakushi/132/3/132_3_251/_pdf

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Equilibrium study on the interaction of phytic acid with polyamines and metalions2011

    • Author(s)
      A. Odani, R. Jastrzab, L. Lomozik
    • Journal Title

      Metallomics

      Volume: 3(7) Issue: 7 Pages: 735-43

    • DOI

      10.1039/c1mt00031d

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Stability and mode of coordination complexes formed in the silver(I)/nucleoside systems2011

    • Author(s)
      R. Jastrzab, Z. Hnatejko, T. Runka, A. Odani, L. Lomozik
    • Journal Title

      New J Chem

      Volume: 35 Issue: 8 Pages: 1672-7

    • DOI

      10.1039/c1nj20230h

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Spectroscopic studies of interactions of chondroitin sulfates with cisplatin2011

    • Author(s)
      JS. Zhang, M. Anraku, D. Kadowaki, T. Imai, A. Suenaga, A. Odani, M. Otagiri
    • Journal Title

      Carbohydr Res

      Volume: 346(5) Issue: 5 Pages: 631-7

    • DOI

      10.1016/j.carres.2011.01.007

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 新しい白金抗がん剤の開発の発想から現状まで2011

    • Author(s)
      小谷明
    • Journal Title

      Biomedical Research on Trace Elements

      Volume: 22(1) Pages: 22-26

    • NAID

      10028118026

    • URL

      http://ci.nii.ac.jp/naid/10028118026/

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The phosphate clamp : a small and independent motif for nucleic acid backbone recognition2011

    • Author(s)
      S. Komeda, T. Moulaei, M. Chikuma, A. Odani, R. Kipping, N. P. Farrell, L. D. Williams
    • Journal Title

      Nucleic Acids Res

      Volume: 39(1) Issue: 1 Pages: 325-336

    • DOI

      10.1093/nar/gkq723

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Equilibrium study on the interaction of phytic acid with polyamines and metal ions2011

    • Author(s)
      A.Odani, R.Jastrzab, L.Lomozik
    • Journal Title

      Metallomics

      Volume: 3(7) Pages: 735-743

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Phosphate Clamp : A Small and Independent Motif for Nucleic Acid Backbone Recognition.2011

    • Author(s)
      N.Farrell, Nicholas, L.Williams, S.Komeda, R.Kipping, T.Moulaei, A.Odani, M.Chikuma
    • Journal Title

      Nucl.Acids Res.

      Volume: 39(1) Pages: 631-637

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adduct formation between ternary Pt(II)-amino acid-aromatic diimine complexes and flavin mononucleotide and its effect on redox properties2009

    • Author(s)
      Y. Nakabayashi, M. Tashiro, T. Yajima, M. Takani, A. Tani, T. Motoyama, A. Odani, O. Yamauchi
    • Journal Title

      Inorg Chim Acta

      Volume: 362 Pages: 777-783

    • URL

      http://dx.doi.org/10.1016/j.ica.2008.03.054

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] Pt, Zn含有医薬品から見た元素の体内動態2012

    • Author(s)
      小谷明
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道大学(北海道)
    • Year and Date
      2012-03-29
    • Related Report
      2011 Final Research Report
  • [Presentation] Pt,Zn含有医薬品から見た元素の体内動態2012

    • Author(s)
      小谷明
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      2012-03-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] 低腎毒性三核Pt(II)抗がん剤の開発2011

    • Author(s)
      竹中淳平,黄檗達人,小川数馬,小谷明
    • Organizer
      錯体化学会第61回討論会
    • Place of Presentation
      岡山理科大学(岡山県)
    • Year and Date
      2011-09-18
    • Related Report
      2011 Final Research Report
  • [Presentation] 低腎毒性三核Pt(II)抗がん剤の開発2011

    • Author(s)
      竹中淳平・黄檗達人・小川数馬・小谷明
    • Organizer
      第61回錯体化学討論会
    • Place of Presentation
      岡山理科大学(岡山市)
    • Year and Date
      2011-09-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] IP6 containing multinuclear platinum(II) complexes for bone metastasis2011

    • Author(s)
      J. Takenaka, T. Kiwada, K. Ogawa, A. Odani
    • Organizer
      The 5th International Conference on Metals and Genetics(ICMG2011)
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Year and Date
      2011-09-06
    • Related Report
      2011 Final Research Report
  • [Presentation] IP6 containing multinuclear platinum(II) complexes for bone metastasis2011

    • Author(s)
      Akira Odani
    • Organizer
      The 5th International Conference on Metals and Genetics (ICMG 2011)
    • Place of Presentation
      神戸国際会議場(神戸市)(招待講演)
    • Year and Date
      2011-09-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] プロテアソーム阻害活性を示す白金錯体の構造活性相関2011

    • Author(s)
      黄檗達人,加藤正弘,小川数馬,小谷明
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡グランシップ(静岡県)
    • Year and Date
      2011-03-29
    • Related Report
      2011 Final Research Report
  • [Presentation] プロテアソームを標的とする白金錯体[Pt(bpy)(AtC2)]Cl_2の構造活性相関2011

    • Author(s)
      黄葉達人
    • Organizer
      第131回日本薬学会年会
    • Place of Presentation
      (東日本大震災のため誌上開催)
    • Year and Date
      2011-03-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] 核内のリン酸アニオン-カチオン特異的相互作用-IP6とスペルミン2010

    • Author(s)
      小谷明,小川数馬,黄檗達人,リナタジャストラザブ,レコスラフロモジク
    • Organizer
      2回メタロミクス研究フォーラム
    • Place of Presentation
      京都薬科大学(京都府)
    • Year and Date
      2010-11-03
    • Related Report
      2011 Final Research Report
  • [Presentation] 核内のリン酸アニオン-カチオン特異的相互作用-IP6とスペルミン2010

    • Author(s)
      小谷明
    • Organizer
      第2回メタロミクス研究フォーラム
    • Place of Presentation
      京都薬科大学(京都府)
    • Year and Date
      2010-11-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 腎毒性の小さなイオン性新規抗がん白金(II)化合物2010

    • Author(s)
      小谷明,小川数馬
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2010-09-23
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 銅(II)がサリチル酸-ヒトアルブミン結合に及ぼす相互作用の新手法による解明2010

    • Author(s)
      小谷明
    • Organizer
      第21回微量元素学会
    • Place of Presentation
      京都大学(京都府)
    • Year and Date
      2010-07-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] Synthesis and characterization of less nephrotoxic and bone targeting multi-nuclear platinum(II) complexes with IP62010

    • Author(s)
      竹中淳平,黄檗達人,小川数馬,小谷明
    • Organizer
      第20回金属の関与する生体関連反応シンポジウム
    • Place of Presentation
      徳島文理大学(徳島県)
    • Year and Date
      2010-06-26
    • Related Report
      2011 Final Research Report
  • [Presentation] IP6含有抗がん多核白金錯体の合成と性質2010

    • Author(s)
      竹中淳平
    • Organizer
      第20回金属の関与する生体関連反応シンポジウム
    • Place of Presentation
      徳島文理大学(徳島県)
    • Year and Date
      2010-06-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] シスプラチン結合DNAをテンプレートとしたPt, Pd錯体の特性2010

    • Author(s)
      竹森麻美,黄檗達人,小川数馬,小谷明
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山大学(岡山県)
    • Year and Date
      2010-03-28
    • Related Report
      2011 Final Research Report
  • [Presentation] シスプラチン結合DNAをテンプレートとしたPt, Pd錯体の特性2010

    • Author(s)
      竹森麻美
    • Organizer
      日本薬学会第130回年会
    • Place of Presentation
      岡山大学 (岡山市)
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] Non-Covalent Interaction Type Anticancer Pt(II) and Pd(II) Complexes2009

    • Author(s)
      A. Odani, H. Takayama, M. Takemori
    • Organizer
      14th International Conference on Biological Inorganic Chemistry
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2009-07-29
    • Related Report
      2011 Final Research Report
  • [Presentation] Non-Covalent Interaction Type Anticancer Pt (II) and Pd (II) Complexes2009

    • Author(s)
      小谷明
    • Organizer
      14th International Conference on Biological Inorganic Chemistry (ICBIC14)
    • Place of Presentation
      名古屋国際会議場 (名古屋市)
    • Year and Date
      2009-07-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] リン酸基含有IP6多核白金抗がん剤の開発2009

    • Author(s)
      竹中淳平,黄檗達人,小川数馬,小谷明
    • Organizer
      日本薬学会北陸支部第121回例会
    • Place of Presentation
      金沢大学(石川県)
    • Year and Date
      2009-07-11
    • Related Report
      2011 Final Research Report
  • [Presentation] Cisplatinと異なる抗ガン作用を有する白金錯体の開発2009

    • Author(s)
      竹森麻美,黄檗達人,小川数馬,小谷明
    • Organizer
      日本薬学会北陸支部第121回例会
    • Place of Presentation
      金沢大学(石川県)
    • Year and Date
      2009-07-11
    • Related Report
      2011 Final Research Report
  • [Presentation] cisplatin と異なる抗ガン作用を有する白金錯体の開発2009

    • Author(s)
      竹森麻美
    • Organizer
      日本薬学会北陸支部平成21年度第120回例会
    • Place of Presentation
      金沢大学 (金沢市)
    • Year and Date
      2009-07-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] リン酸基含有IP6多核白金抗がん剤の開発2009

    • Author(s)
      竹中淳平
    • Organizer
      日本薬学会北陸支部平成21年度第120回例会
    • Place of Presentation
      金沢大学 (金沢市)
    • Year and Date
      2009-07-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] 腎毒性軽減を目指した白金抗がん剤の開発2009

    • Author(s)
      小谷明
    • Organizer
      鈴鹿医療科学大学薬学部セミナー
    • Place of Presentation
      鈴鹿医療科学大学(三重県)
    • Year and Date
      2009-07-03
    • Related Report
      2011 Final Research Report
  • [Presentation] 新しい制がん機構を有する白金錯体2009

    • Author(s)
      小谷明
    • Organizer
      第20回日本微量元素学会学術集会
    • Place of Presentation
      京王プラザ(東京都)
    • Year and Date
      2009-07-03
    • Related Report
      2011 Final Research Report
  • [Presentation] 新しい制がん機構を有する白金錯体2009

    • Author(s)
      小谷明
    • Organizer
      第20回微量元素学会
    • Place of Presentation
      京王プラザホテル (東京都)
    • Year and Date
      2009-07-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] 骨親和性白金錯体の特性と抗がん剤への応用2009

    • Author(s)
      小谷明,田邊和行,米田誠治,小川数馬
    • Organizer
      第19回金属の関与する生体関連反応シンポジウム
    • Place of Presentation
      大阪大学銀杏会館(大阪府)
    • Year and Date
      2009-06-11
    • Related Report
      2011 Final Research Report
  • [Presentation] 骨親和性白金錯体の特性と抗がん剤への応用2009

    • Author(s)
      小谷明
    • Organizer
      第19回金属の関与する生体関連反応シンポジウム
    • Place of Presentation
      銀杏会館 (吹田市)
    • Year and Date
      2009-06-11
    • Related Report
      2009 Annual Research Report
  • [Remarks] 2010. 7. 10北国新聞朝刊新聞掲載

    • URL

      http://www.p.kanazawa-u.ac.jp/~bunseki/research.html

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.p.kanazawa-u.ac.jp/~bunseki/research.html

    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] 金属錯体およびこれを有効成分として含有する抗がん剤2010

    • Inventor(s)
      小谷明
    • Industrial Property Rights Holder
      金沢大学
    • Industrial Property Number
      2010-008343
    • Filing Date
      2010-03-31
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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