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Micro-Scale Sample Preparation Devices for Novel Non-Invasive Screening Diagnosis with Human Breath Samples

Research Project

Project/Area Number 21550078
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Analytical chemistry
Research InstitutionToyohashi University of Technology

Principal Investigator

SAITO Yoshihiro  豊橋技術科学大学, 大学院・工学研究科, 准教授 (00303701)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords試料処理 / 呼気診断 / 非侵襲診断 / マイクロ化 / 針型デバイス / 糖尿病 / 抽出 / 試料前処理 / 呼気分析 / マイクロ抽出法 / 高感度検出 / ガスクロマトグラフィー / 非侵襲診断技術 / 空気環境測定
Research Abstract

In this work, a novel non-invasive diagnosis technique with human breath sample was developed for the screening of diabetic patients. The developed needle-type sample preparation method has several advantageous features such as an excellent storage performance and easy operations during the sampling process. The correlation between the acetone concentration in breath samples and the total concentrations of ketone bodies was confirmed along with a good correlation between the acetone concentration and the HbA1c% in blood, suggesting a successful development of this technique as a quick screening technique.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (32 results)

All 2012 2011 2010 2009

All Journal Article (18 results) (of which Peer Reviewed: 18 results) Presentation (13 results) Book (1 results)

  • [Journal Article] "間接受動喫煙(三次喫煙)の潜在的リスク-喫煙関連物質の精密測定による評価-"(" Potential Risk of Third-Hand Smoking")2012

    • Author(s)
      齊戸美弘
    • Journal Title

      日本胸部臨床

      Volume: (印刷中)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] ガスクロマトグラフィーのための針型試料前処理デバイス2011

    • Author(s)
      植田郁生, 齊戸美弘
    • Journal Title

      分析化学

      Volume: 60(11) Pages: 833-844

    • NAID

      10030038180

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Retention Behavior of Fluorobenzenes on Fluoro-Derivatized Poly(p-phenylene terephthalamide) Fibrous Stationary Phases in Microcolumn Liquid Chromatography2011

    • Author(s)
      S. Shirai, K. Nakane, I. Ueta and Y. Saito
    • Journal Title

      Chromatography

      Volume: 32(3) Pages: 127-133

    • NAID

      10030146100

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] High-Temperature Separation on a Polymer-Coated Fibrous Stationary Phase in Microcolumn Liquid Chromatography2011

    • Author(s)
      K. Nakane, S. Shirai, Y. Saito, Y. Moriwake, I. Ueta, M Inoue and K. Jinno
    • Journal Title

      Analytical Sciences

      Volume: 27 Pages: 811-816

    • NAID

      10029600211

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] High-Temperature Separations on a Polymer-Coated Fibrous Stationary Phase in Microcolumn Liquid Chromatography2011

    • Author(s)
      K.Nakane
    • Journal Title

      Analytical Sciences

      Volume: 27 Issue: 8 Pages: 811

    • DOI

      10.2116/analsci.27.811

    • NAID

      130004442040

    • ISSN
      0910-6340, 1348-2246
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Needle-Type Sample Preparation Devices for Gas Chromatographic Analysis2011

    • Author(s)
      植田郁生
    • Journal Title

      BUNSEKI KAGAKU

      Volume: 60 Issue: 11 Pages: 833-844

    • DOI

      10.2116/bunsekikagaku.60.833

    • NAID

      10030038180

    • ISSN
      0525-1931
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel Fire Investigation Technique Using Needle Extraction in Gas Chromatography2010

    • Author(s)
      I. Ueta, Y. Saito, K. Teraoka, H. Matsuura, K. Fujimura and K. Jinno
    • Journal Title

      Analytical Sciences

      Volume: 26 Pages: 1127-1132

    • NAID

      10027315935

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Retention Behavior on Amino ethyl-Modified Poly(p-phenylene terephthalamide) Fiber Stationary Phases in Gas Chromatography2010

    • Author(s)
      S. Shirai, Y. Saito, Y. Sakurai, I. Ueta and K. Jinno
    • Journal Title

      Analytical Sciences

      Volume: 26 Pages: 1011-1014

    • NAID

      10026785477

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rapid Temperature-Programmed Separation and Retention Prediction on Novel Packed-Capillary Column in Gas Chromatography2010

    • Author(s)
      M. Inoue, Y. Saito, I. Ueta, T. Miura, H. Ohkita, K. Fujimura and K. Jinno
    • Journal Title

      Analytical Sciences

      Volume: 26 Pages: 687-691

    • NAID

      10026784116

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Determination of Volatile Organic Compounds for a Systematic Evaluation of Third-Hand Smoking2010

    • Author(s)
      I. Ueta, Y. Saito, K. Teraoka, T. Miuraand K. Jinno
    • Journal Title

      Analytical Sciences

      Volume: 26 Pages: 569-574

    • NAID

      10026783539

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rapid Temperature-Programmed Separation and Retention Prediction on Novel Packed-Capillary Column in Gas Chromatography2010

    • Author(s)
      M.Inoue
    • Journal Title

      Analytical Sciences

      Volume: 26巻 Pages: 687-691

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Retention Behavior on Aminoethyl-Modified Poly(p-phenylene terephthalamide) Fiber Stationary Phases in Gas Chromatography2010

    • Author(s)
      S.Shirai
    • Journal Title

      Analytical Sciences

      Volume: 26巻 Pages: 1011-1014

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of Novel Fiber-Packed Needle Interface for Off-Line Reversed-Phase Liquid Chromatography-Capillary Gas Chromatography2009

    • Author(s)
      A. Abe, Y. Saito, I. Ueta, K. Nakane, T. Takeichi and K. Jinno
    • Journal Title

      Journal of Chromatography A

      Volume: 1216 Pages: 7456-7460

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Breath Acetone Analysis with Miniaturized Sample Preparation Device : In-Needle Preconcentration and Subsequent Determination by Gas Chromatography-Mass Spectroscopy2009

    • Author(s)
      I. Ueta, Y. Saito, M. Hosoe, M. Okamoto, H. Ohkita, S. Shirai, H. Tamura and K. Jinno
    • Journal Title

      Journal of Chromatography B

      Volume: 877 Pages: 2551-2556

    • NAID

      10028022229

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Determination of Bisphenol A in Water Using a Packed Needle Extraction Device2009

    • Author(s)
      M. Ogawa, Y. Saito, S. Shirai, Y. Kisoand K. Jinno
    • Journal Title

      Chromatographia

      Volume: 69 Pages: 685-690

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rapid Determination of Ethylene Oxide with Fiber-Packed Sample Preparation Needle2009

    • Author(s)
      I. Ueta, Y. Saito, N. B. A. Ghani, M. Ogawa, K. Yogo, A. Abe, S. Shirai and K. Jinno
    • Journal Title

      Journalof Chromatography A

      Volume: 1216 Pages: 2848-2853

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fiber-Packed Needle-Type Sample Preparation Device Designed for Gas Chromatographic Analysis2009

    • Author(s)
      Y. Saito, I. Ueta, M. Ogawa, A. Abe, K. Yogo, S. Shirai and K. Jinno
    • Journal Title

      Analytical and Bioanalytical Chemistry

      Volume: 393 Pages: 861-869

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Breath Acetone Analysis with Miniaturized Sample Preparation Device : In-Needle Preconcentration and Subsequent Determination by Gas Chromatography-Mass Spectroscopy2009

    • Author(s)
      I.Ueta
    • Journal Title

      Journal of Chromatography B 877

      Pages: 2551-2556

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Miniaturized Sample Preparation Devices for Various Analytical Situations2011

    • Author(s)
      Y. Saito
    • Organizer
      11th AsiaPacific International Symposium on Microscale Separations and Analysis(APCE 2011)
    • Place of Presentation
      University of Tasmania, Hobart, Tasmania, Australia
    • Year and Date
      2011-11-26
    • Related Report
      2011 Final Research Report
  • [Presentation] Miniaturized Sample Preparation Devices for Various Analytical Situations2011

    • Author(s)
      Y.Saito
    • Organizer
      11th Asia Pacific International Symposium on Microscale Separations and Analysis (APCE 2011)
    • Place of Presentation
      タスマニア大学(オーストラリア,タスマニア州,ホバート市)(招待講演)
    • Year and Date
      2011-11-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] 針型試料前処理デバイスの開発と応用2011

    • Author(s)
      齊戸美弘
    • Organizer
      日本分析化学会第60年会ガスクロマトグラフィー研究懇談会特別講演会
    • Place of Presentation
      愛知県名古屋市・名古屋大学
    • Year and Date
      2011-09-14
    • Related Report
      2011 Final Research Report
  • [Presentation] 針型試料前処理デバイスの開発と応用2011

    • Author(s)
      齊戸美弘
    • Organizer
      日本分析化学会第60年会
    • Place of Presentation
      名古屋大学(愛知県名古屋市)(招待講演)
    • Year and Date
      2011-09-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] Miniaturized Sample Preparation Device Designed for Gas Chromatographic Analysis of Various Volatile Organic Compounds2011

    • Author(s)
      Y. Saito
    • Organizer
      Separation Science Asia 2011-New Horizons in Separation and Detection Techniques-
    • Place of Presentation
      TheBiopolis Science Park, Singapore, Singapore
    • Year and Date
      2011-07-28
    • Related Report
      2011 Final Research Report
  • [Presentation] Miniaturized Sample Preparation Device Designed for Gas Chromatographic Analysis of Various Volatile Organic Compounds2011

    • Author(s)
      Y.Saito
    • Organizer
      Separation Science Asia 2011--New Horizons in Separation and Detection Techniques--
    • Place of Presentation
      バイオポリスサイエンスパーク(シンガポール)(招待講演)
    • Year and Date
      2011-07-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] Miniaturized Sample Preparation Device for Gas Chromatographic Analysis of Volatile Organic Compounds2010

    • Author(s)
      Y. Saito
    • Organizer
      The International Chemical Congress of Pacific Basin Societies(PACIFICHEM 2010)
    • Place of Presentation
      Hawaii Convention Center, Honolulu, Hawaii, HI, USA
    • Year and Date
      2010-12-19
    • Related Report
      2011 Final Research Report
  • [Presentation] Miniaturized Sample Preparation Device for Gas Chromatographic Analysis of Volatile Organic Compounds2010

    • Author(s)
      Y.Saito
    • Organizer
      The International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010)
    • Place of Presentation
      Hawaii Convention Center(米国、ホノルル)
    • Year and Date
      2010-12-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] マイクロ試料前処理技術の新展開2010

    • Author(s)
      齊戸美弘
    • Organizer
      第41回中部化学関係学協会支部連合秋季大会
    • Place of Presentation
      愛知県豊橋市・豊橋技術科学大学
    • Year and Date
      2010-11-06
    • Related Report
      2011 Final Research Report
  • [Presentation] Sample Preparation Devicefor Human Breath Analysis in Capillary Gas Chromatography2010

    • Author(s)
      Y. Saito
    • Organizer
      34th International Symposium on Capillary Chromatography(ISCC 2010)
    • Place of Presentation
      Palazzo dei Congressi, Rivadel Garda, Italy
    • Year and Date
      2010-06-04
    • Related Report
      2011 Final Research Report
  • [Presentation] Sample Preparation Device for Human Breath Analysis in Capillary Gas Chromatography2010

    • Author(s)
      Y.Saito
    • Organizer
      34th International Symposium on Capillary Chromatography (ISCC 2010)
    • Place of Presentation
      Palazzo dei Congressi(イタリア,リバデルガルダ)
    • Year and Date
      2010-06-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] Polymer Particle-Packed Sample Preparation Needle for the Determination of Breath Acetone by Gas Chromatography-Mass Spectrometry2009

    • Author(s)
      植田郁生
    • Organizer
      ExTech 2009
    • Place of Presentation
      Rapid City, SD, USA
    • Year and Date
      2009-10-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] ポリマー粒子充填針型試料前処理デバイスによる呼気中VOCの測定 (Analysis of VOCs in Breath with Polymer Particle-Packed Extraction Needle)2009

    • Author(s)
      植田郁生
    • Organizer
      第16回クロマトグラフィーシンポジウム
    • Place of Presentation
      長崎県長崎市・長崎大学
    • Year and Date
      2009-05-30
    • Related Report
      2009 Annual Research Report
  • [Book] Needle Trap Devices for Environmental Sample Preparation2012

    • Author(s)
      Y. Saito, I. Ueta, M. Ogawa and K. Jinno
    • Publisher
      Elsevier Science B. V., Amsterdam, The Netherlands
    • Related Report
      2011 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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