Developments of selective detection methods of oligosaccharides bound to receptor molecule
| Project/Area Number |
21550092
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Analytical chemistry
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| Research Institution | Meisei University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIMURA Etsuro 東京大学, 大学院・農学生命科学研究科, 教授 (10130303)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 生物学的分析 / 高精度選択的分析 / レセブター・リガンド複合体 / 選択的検出 / 核磁気共鳴 / 分子間相互作用 / 高感度化・高精度化 / タンパク質 / リガンド |
|---|
| Research Abstract |
Various new methods to detect interactions of the protein-ligandcomplex have been developed. Although sample solutions containing 100% D_2O weregenerally used in the previous studies, new methods, which can handle 95% H_2O and 5% D_2O, were required on the point of easy sample preparation with avoiding sample loss. Effective and sensitive detection of ligand signals, resonating close to water, was alsoperformed in this research project. These methods are expected to be useful in thechemical and pharmaceutical fields.
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Report
(4 results)
Research Products
(41 results)
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[Journal Article] Demonstration of three dopamine molecules bound to α-synuclein : Implication of oligomerization at the initial stage
Author(s)
S.Shimotakahara, Y.Shiroyama, T.Fujimoto, M.Akai, T.Onoue, H.Seki, S.Kado, T.Machinami, Y.Shibusawa, K.Ueda, Mitsuru Tashiro
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Journal Title
J.Biophy.Chem.
Volume: (印刷中)
Related Report
Peer Reviewed
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