Development of magnetic nanoparticles for non-invasive early diagnosis of acute myocardial infarction
Project/Area Number |
21550165
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Chemistry related to living body
|
Research Institution | Chubu University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Takeshi 中部大学, 生物機能開発研究所, 客員教授 (10043324)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | ナノ材料 / 磁性 / マグネタイト / マクロファージ / 標的指向性 / 核磁気共鳴画像法(MRI) / 造影剤 / がん / 磁性ナノ粒子 / 高温熱分解法 / 急性心筋梗塞 |
Research Abstract |
Ligands-bound magnetite nanoparticles(MNPs) have been expected as enhancing agents for magnetic resonance imaging(MRI). To develop MNPs for non-invasive early diagnosis of acute myocardial infarction, we prepared MNPs coated with 4-methylcatechol(4-MC) and N-vinyl-2-pyrrolidone/methyl methacrylate/methacryl acid terpolymer [P(VP-MMA-MA)] by thermal decomposition of iron pentacarbonyl, and conjugated MNPs with ligand molecules to target macrophages.
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Report
(4 results)
Research Products
(34 results)