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Development of magnetic nanoparticles for non-invasive early diagnosis of acute myocardial infarction

Research Project

Project/Area Number 21550165
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Chemistry related to living body
Research InstitutionChubu University

Principal Investigator

TSUTSUMIUCHI Kaname  中部大学, 応用生物学部, 准教授 (50329851)

Co-Investigator(Kenkyū-buntansha) KOBAYASHI Takeshi  中部大学, 生物機能開発研究所, 客員教授 (10043324)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsナノ材料 / 磁性 / マグネタイト / マクロファージ / 標的指向性 / 核磁気共鳴画像法(MRI) / 造影剤 / がん / 磁性ナノ粒子 / 高温熱分解法 / 急性心筋梗塞
Research Abstract

Ligands-bound magnetite nanoparticles(MNPs) have been expected as enhancing agents for magnetic resonance imaging(MRI). To develop MNPs for non-invasive early diagnosis of acute myocardial infarction, we prepared MNPs coated with 4-methylcatechol(4-MC) and N-vinyl-2-pyrrolidone/methyl methacrylate/methacryl acid terpolymer [P(VP-MMA-MA)] by thermal decomposition of iron pentacarbonyl, and conjugated MNPs with ligand molecules to target macrophages.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (34 results)

All 2012 2011 2010 2009 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (26 results) Remarks (4 results)

  • [Journal Article] N-ビニル-2-ピロリドン/メタクリル酸メチル/メタクリル酸三元共重合体被覆マグネタイトナノ粒子の調製と特性解析2012

    • Author(s)
      山城舞, 杉村俊英, 小林猛, 堤内要
    • Journal Title

      高分子論文集

      Volume: (印刷中)

    • NAID

      10030932362

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cancer hyperthermia using magnetic nanoparticles2011

    • Author(s)
      Takeshi Kobayashi
    • Journal Title

      Biotechnology Journal

      Volume: Vol.6, No.11 Issue: 11 Pages: 1342-1347

    • DOI

      10.1002/biot.201100045

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anti-cancer effect of hyperthermia on breast cancer by magnetite nanoparticle-loaded anti-HER2 immunoliposomes2009

    • Author(s)
      Toyone Kikumori, Takeshi Kobayashi, Masataka Sawaki, Tsuneo Imai
    • Journal Title

      Breast Cancer Research and Treatment

      Volume: Vol.113, No.3 Issue: 3 Pages: 435-441

    • DOI

      10.1007/s10549-008-9948-x

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anti-cancer effect of hyperthermia on breast cancer by magnetite nanoparticle-loaded anti-HER2 immunoliposomes2009

    • Author(s)
      Toyone Kikumori
    • Journal Title

      Breast Cancer Research Treatment 113

      Pages: 435-441

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] ポリ(ビニルピロリドン-co-メタクリル酸)被覆マグネタイトナノ粒子に結合したハーセプチンの定量分析2012

    • Author(s)
      堤内要, ほか3名
    • Organizer
      第61回高分子学会年次大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2012-05-29
    • Related Report
      2011 Final Research Report
  • [Presentation] 4-メチルカテコール被覆マグネタイトナノ粒子と(1→3)-β-D-グルコピラナンの複合化2012

    • Author(s)
      堤内要, ほか3名
    • Organizer
      第61回高分子学会年次大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2012-05-29
    • Related Report
      2011 Final Research Report
  • [Presentation] がん温熱療法用Fe_3O_4ナノ粒子の最適合成条件の検討と物性評価(II)2012

    • Author(s)
      與語勇輝, 堤内要, ほか4名
    • Organizer
      第59回応用物理学関係連合講演会
    • Place of Presentation
      早稲田大学早稲田キャンパス
    • Year and Date
      2012-03-16
    • Related Report
      2011 Final Research Report
  • [Presentation] がん温熱療法用Fe3O4ナノ粒子の最適合成条件の検討と物性評価(II)2012

    • Author(s)
      與語勇輝
    • Organizer
      第59回応用物理関係連合講演会
    • Place of Presentation
      早稲田大学早稲田キャンパス(東京都)
    • Year and Date
      2012-03-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] 抗体を有するポリ(ビニルピロリドン-co-メタクリル酸)被覆マグネタイトナノ粒子の特性解析2011

    • Author(s)
      堤内要, ほか2名
    • Organizer
      第16回高分子分析討論会
    • Place of Presentation
      工学院大学新宿校舎
    • Year and Date
      2011-10-26
    • Related Report
      2011 Final Research Report
  • [Presentation] 抗体を有するポリ(ビニルピロリドン-co-メタクリル酸)被覆マグネタイトナノ粒子の特性解析2011

    • Author(s)
      杉村俊英
    • Organizer
      第16回高分子分析討論会
    • Place of Presentation
      工学院大学新宿校舎(東京都)
    • Year and Date
      2011-10-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] HER2高発現胃癌細胞を指向するポリ(ビニルピロリドン-co-メタクリル酸)被覆マグネタイトナノ粒子の調製と機能2011

    • Author(s)
      堤内要, 小林猛, ほか3名
    • Organizer
      第60回高分子討論会
    • Place of Presentation
      岡山大学津島キャンパス
    • Year and Date
      2011-09-29
    • Related Report
      2011 Final Research Report
  • [Presentation] HER2高発現胃癌細胞を指向するポリ(ビニルピロリドン-co-メタクリル酸)被覆マグネタイトナノ粒子の調製と機能2011

    • Author(s)
      堤内要
    • Organizer
      第60回高分子討論会
    • Place of Presentation
      岡山大学津島キャンパス(岡山県)
    • Year and Date
      2011-09-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] 抗体を導入したポリ(ビニルピロリドン-co-メタクリル酸)被覆マグネタイトナノ粒子の調製と機能2011

    • Author(s)
      堤内要
    • Organizer
      第137回東海高分子研究会講演会
    • Place of Presentation
      湯の山温泉グリーンホテル(三重県)
    • Year and Date
      2011-09-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] がん温熱療法用Fe_3O_4ナノ粒子の合成と物性評価2011

    • Author(s)
      與語勇輝, 堤内要, ほか2名
    • Organizer
      第72回応用物理学会学術講演会
    • Place of Presentation
      山形大学小白川キャンパス
    • Year and Date
      2011-08-30
    • Related Report
      2011 Final Research Report
  • [Presentation] がん温熱療法用Fe3O4ナノ粒子の合成と物性評価2011

    • Author(s)
      與語勇輝
    • Organizer
      第72回応用物理学会学術講演会
    • Place of Presentation
      山形大学小白川キャンパス(山形県)
    • Year and Date
      2011-08-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] ハーセプチンを有するポリ(ビニルピロリドン-co-メタクリル酸)被覆マグネタイトナノ粒子のHER-2高発現胃癌細胞への取込2011

    • Author(s)
      堤内要, 小林猛, ほか3名
    • Organizer
      第60回高分子学会年次大会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2011-05-25
    • Related Report
      2011 Final Research Report
  • [Presentation] ハーセプチンを有するポリ(ビニルピロリドン-co-メタクリル酸)被覆マグネタイトナノ粒子のHER2高発現胃癌細胞への取込2011

    • Author(s)
      堤内要
    • Organizer
      第60回高分子学会年次大会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Year and Date
      2011-05-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] Analysis of 4-Methylcatechol-coated Magnetite Nanoparticles by Reactive Pyrolysis-Gas Chromatography2010

    • Author(s)
      Kaname Tsutsumiuchi, Takeshi Kobayashi, et al
    • Organizer
      International Conference on Polymer Analysis and Characterization & 15th Symposium on Polymer Analysis in Japan'(ICPAC)
    • Place of Presentation
      Nagoya Congress Center
    • Year and Date
      2010-12-10
    • Related Report
      2011 Final Research Report
  • [Presentation] Analysis of 4-Methylcatechol-coated magnetite nanoparticles by reactive pyrolysis-gas chromatography2010

    • Author(s)
      K.Tsutsumiuchi
    • Organizer
      International Conference on Polymer Analysis and Characterization & 15th Symposium on Polymer Analysis in Japan (ICPAC)
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2010-12-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] ハーセプチンを有するポリ(ビニルピロリドン-co-メタクリル酸)被覆マグネタイトナノ粒子の合成と機能2010

    • Author(s)
      堤内要, 小林猛, ほか3名
    • Organizer
      第59回高分子討論会
    • Place of Presentation
      北海道大学
    • Year and Date
      2010-09-16
    • Related Report
      2011 Final Research Report
  • [Presentation] ハーセプチンを有するポリ(ビニルピロリドン-co-メタクリル酸)被服マグネタイトナノ粒子の合成と機能2010

    • Author(s)
      堤内要
    • Organizer
      第59回高分子討論会
    • Place of Presentation
      北海道大学
    • Year and Date
      2010-09-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Synthesis of Carbohydrates-Coated Magnetite Nanoparticles Using Click Chemistry2010

    • Author(s)
      Kaname Tsutsumiuchi, Takeshi Kobayashi, et al
    • Organizer
      25th International Carbohydrate Symposium(ICS2010)
    • Place of Presentation
      Makuhari Messe International Conference Hall
    • Year and Date
      2010-08-05
    • Related Report
      2011 Final Research Report
  • [Presentation] Synthesis of Carbohydrates-Coated Magnetite Nanoparticles Using Click Chemistry2010

    • Author(s)
      K.Tsutsumiuchi
    • Organizer
      25th International Carbohydrate Symposium (ICS2010)
    • Place of Presentation
      幕張メッセ
    • Year and Date
      2010-08-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] ポリ(ビニルピロリドン-co-メタクリル酸)誘導体を用いたマグネタイトナノ粒子の調製2010

    • Author(s)
      堤内要, 小林猛, ほか4名
    • Organizer
      第59回高分子学会年次大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2010-05-27
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 磁性ナノ粒子の調製と抗体結合2009

    • Author(s)
      堤内要, 小林猛, ほか4名
    • Organizer
      第61回日本生物工学会大会
    • Place of Presentation
      名古屋大学
    • Year and Date
      2009-09-24
    • Related Report
      2011 Final Research Report
  • [Presentation] 磁性ナノ粒子の調製と抗体結合2009

    • Author(s)
      伊東真弓
    • Organizer
      日本生物工学会
    • Place of Presentation
      名古屋大学(名古屋市)
    • Year and Date
      2009-09-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] 高温熱分解法などを利用した温熱治療のための磁性ナノ粒子の調製2009

    • Author(s)
      堤内要, 小林猛, ほか5名
    • Organizer
      日本ハイパーサーミア学会第26回大会
    • Place of Presentation
      千葉大学
    • Year and Date
      2009-09-12
    • Related Report
      2011 Final Research Report
  • [Presentation] 高温熱分解法などを利用した温熱治療のための磁性ナノ粒子の調製2009

    • Author(s)
      伊東真弓
    • Organizer
      日本ハイパーサーミア学会
    • Place of Presentation
      千葉大学(千葉市)
    • Year and Date
      2009-09-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] 磁性微粒子を利用した癌の温熱免疫療法の開発-進行期メラノーマに対する温熱免疫療法2009

    • Author(s)
      小林猛
    • Organizer
      日本ハイパーサーミア学会第26回大会
    • Place of Presentation
      神戸大学
    • Year and Date
      2009-07-19
    • Related Report
      2011 Final Research Report
  • [Presentation] 磁性微粒子を利用した癌の温熱免疫療法の開発2009

    • Author(s)
      小林猛
    • Organizer
      分子病理学研究会
    • Place of Presentation
      神戸大学(神戸市)
    • Year and Date
      2009-07-19
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://stu.isc.chubu.ac.jp/bio/public/Bio_Chem/labo/tsutsumiuchi_lab/index.htm

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://stu.isc.chubu.ac.jp/bio/public/Bio_Chem/labo/tsutsumiuchi_lab/index.htm

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://stu.isc.chubu.ac.jp/bio/public/Bio_Chem/labo/tsutsumiuchi_lab/index.htm

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://stu.isc.chubu.ac.jp/bio/public/Bio_Chem/labo/tsutsumiuchi_lab/index.htm

    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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