Synthesis and Application of Artificial Receptors That Recognize Fluorous Compounds

• Project/Area Number: 21550166
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Chemistry related to living body
• Research Institution: Konan University
• Principal Investigator: MATSUI Jun 甲南大学, フロンティアサイエンス学部, 教授 (10264954)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: パーフルオロオクタン酸 / PFOA / モレキュラーインプリンティング / 分子認識 / 反射型干渉分光法 / RIfS / 生体材料 / 環境 / 界面活性剤 / モレキュラーインプリンティング法 / 液体クロマトグラフィー / 水素結合 / 有機フッ素化合物 / 免疫吸着剤

Research Abstract

An artificial receptor that recognizes a fluorosurfactant perfluorooctanoic acid(PFOA) was synthesized by a molecular imprinting technique, and was demonstrated to be useful as HPLC stationary phase and recognition element of a reflectometric interference spectroscopy(RIfS) sensor.

Research Products

• [Journal Article] Monodispersed Molecularly Imprinted Polymer Beads with Enhanced Atrazine Retention Ability Synthesized with Polymeric Diluents (2012)
  • Author(s): Tsuyoshi Nagata, Shou Goji, Kensuke Akamatsu, Hidemi, Nawafune, Jun Matsui
  • Journal Title: Analytical Letters Volume: 45
  • Peer Reviewed
• [Journal Article] A Fluorous Synthetic Receptor That Recognizes Perfluorooctanoic Acid(PFOA) via Fluorous Interaction Obtained by Molecular Imprinting (2012)
  • Author(s): Megumi Takayose, Kenji Nishimoto, Jun Matsui
  • Journal Title: Analyst Volume: 137 Pages: 2762-2765
  • Peer Reviewed
• [Journal Article] Monodispersed Molecularly Imprinted Polymer Beads with Enhanced Atrazine Retention Ability Synthesized with Polymeric Diluents (2012)
  • Author(s): Tsuyoshi Nagata, Shou Goji, Kensuke Akamatsu, Hidemi Nawafune, Jun Matsui
  • Journal Title: Analytical Letters Volume: 45(印刷中) Issue: 9 Pages: 977-985
  • DOI: 10.1080/00032719.2012.670786
  • Peer Reviewed
• [Journal Article] A fluorous synthetic receptor that recognizes perfluorooctanoic acid (PFOA) via fluorous interaction obtained by molecular imprinting (2012)
  • Author(s): Megumi Takayose, Kenji Nishimoto, Jun Matsui
  • Journal Title: Analyst Volume: 137(印刷中) Issue: 12 Pages: 2762-2762
  • DOI: 10.1039/c2an15936h
  • Peer Reviewed
• [Journal Article] Thermodynamic stability of Hoogsteen and Watson-Crick base pairs in the presence of histone H3-mimicking peptide (2011)
  • Author(s): Smritimoy Pramanik, Kaori Nakamura, Kenji Usui, Shu-ichi Nakano, Sarika Saxena, Jun Matsui, Daisuke Miyoshi, Naoki Sugimoto
  • Journal Title: Chem. Commun Volume: 47 Pages: 2790-2792
  • Peer Reviewed
• [Journal Article] Direct Detection of Thrombin Binding to 8-Bromodeoxyguanosine-modified Aptamer : Effects of Modification on Affinity and Kinetics (2011)
  • Author(s): Shou Goji, Jun Matsui
  • Journal Title: Journal of Nucleic Acids Volume: 2011 Pages: 1-5
  • DOI: 10.4061/2011/316079
  • Peer Reviewed
• [Journal Article] Thermodynamic stability of Hoogsteen and Watson-Crick base pairs in the presence of histone H3-mimicking peptide (2011)
  • Author(s): Smritimoy Pramanik, Kaori Nakamura, Kenji Usui, Shu-ichi Nakano, Sarika Saxena, Jun Matsui, Daisuke Miyoshi, Naoki Sugimoto
  • Journal Title: Chem.Commun. Volume: 47 Pages: 2790-2792
  • Peer Reviewed
• [Journal Article] Face-to-face Porphyrin Moieties Assembled with Spacing for Pyrazine Recognition in Molecularly Imprinted Polymers (2009)
  • Author(s): Jun Matsui, Takuji Sodeyama, Yumi Saiki, Toshifumi Miyazawa, Takashi Yamada, Katsuyuki Tamaki, Takashi Murashima
  • Journal Title: Biosensors and Bioelectronics Volume: 25 Pages: 635-639
  • Peer Reviewed
• [Journal Article] An Approach to Peptide-based ATP Receptors by a Combination of Random Selection, Rational Design, and Molecular Imprinting (2009)
  • Author(s): Jun Matsui, Junji Nagano, Daisuke Miyoshi, Katsuyuki Tamaki, Naoki Sugimoto
  • Journal Title: Biosensors and Bioelectronics Volume: 25 Pages: 563-567
  • Peer Reviewed
• [Journal Article] Face-to-face porphyrin moieties assembled with spacing for pyrazine recognition in molecularly imprinted polymers (2009)
  • Author(s): Jun Matsui, Takuji Sodeyama, Yumi Saiki, Toshifumi Miyazawa, Takashi Yamada, Katsuyuki Tamaki, Takashi Murashima
  • Journal Title: Biosensors and Bioelectronics 25 Pages: 635-639
  • Peer Reviewed
• [Journal Article] An approach to peptide-based ATP receptors by a combination of random selection, rational design, and molecular imprinting (2009)
  • Author(s): Jun Matsui, Junji Nagano, Daisuke Miyoshi, Katsuyuki Tamaki, Naoki Sugimoto
  • Journal Title: Biosensors and Bioelectronics 25 Pages: 563-567
  • Peer Reviewed
• [Presentation] 分子インプリント高分子によるフッ素化合物の認識とセンシング (2012)
  • Author(s): 中堀祐真、櫻井健志、中川雄市、松井淳
  • Organizer: 日本化学会第92春季年会
  • Place of Presentation: 慶応義塾大学(横浜市)
  • Year and Date: 2012-03-25
• [Presentation] 反射干渉分光法によるブロモ基修飾トロンビンアプタマーの結合能評価 (2011)
  • Author(s): 郷司翔、松井淳
  • Organizer: 第5回バイオ関連化学シンポジウム
  • Place of Presentation: つくば国際会議場(つくば市)
  • Year and Date: 2011-09-13
• [Presentation] アドレナリンインプリント高分子を用いる反射干渉分光センサー用チップの構築 (2011)
  • Author(s): 太田安則、松井淳
  • Organizer: 第5回バイオ関連化学シンポジウム
  • Place of Presentation: つくば国際会議場(つくば市)
  • Year and Date: 2011-09-13
• [Presentation] アガロースゲル内におけるDNA二重鎖構造の形成・解離反応 (2011)
  • Author(s): 山口大輔、中野修一、松井淳
  • Organizer: 日本化学会第91春季年会
  • Place of Presentation: 神奈川大学(横浜市)
  • Year and Date: 2011-03-28
• [Presentation] アガロースゲル内におけるDNA二重鎖構造の形成・解離反応 (2011)
  • Author(s): 山口大輔、中野修一、松井淳
  • Organizer: 日本化学会第91春季年会
  • Place of Presentation: 神奈川大学
  • Year and Date: 2011-03-28
• [Presentation] 生命分子の挙動に及ぼす分子環境の効果(21)人工核酸を使ったDNA構造の水和研究 (2011)
  • Author(s): 中野修一、山口大輔、三好大輔、松井淳、杉本直己
  • Organizer: 日本化学会第91春季年会
  • Place of Presentation: 神奈川大学(横浜市)
  • Year and Date: 2011-03-27
• [Presentation] 生命分子の挙動に及ぼす分子環境の効果(21)人工核酸を使ったDNA構造の水和研究 (2011)
  • Author(s): 中野修一、山口大輔、三好大輔、松井淳、杉本直己
  • Organizer: 日本化学会第91春季年会
  • Place of Presentation: 神奈川大学
  • Year and Date: 2011-03-27
• [Presentation] アプタマー固定化反射干渉分光センサーによるトロンビン検出 (2011)
  • Author(s): 郷司翔、松井淳
  • Organizer: 日本化学会第91春季年会
  • Place of Presentation: 神奈川大学(横浜市)
  • Year and Date: 2011-03-26
• [Presentation] 分子インプリント高分子を用いる反射干渉分光用センサーチップの構築 (2011)
  • Author(s): 太田安則、松井淳
  • Organizer: 日本化学会第91春季年会
  • Place of Presentation: 神奈川大学(横浜市)
  • Year and Date: 2011-03-26
• [Presentation] アプタマー固定化反射干渉分光センサーによるトロンビン検出 (2011)
  • Author(s): 郷司翔、松井淳
  • Organizer: 日本化学会第91春季年会
  • Place of Presentation: 神奈川大学
  • Year and Date: 2011-03-26
• [Presentation] 分子インプリント高分子を用いる反射干渉分光用センサーチップの構築 (2011)
  • Author(s): 太田安則、松井淳
  • Organizer: 日本化学会第91春季年会
  • Place of Presentation: 神奈川大学
  • Year and Date: 2011-03-26
• [Presentation] 8-ブロモデオキシグアノシンの導入によるトロンビン結合アプタマーの高次構造安定性及び親和性の向上 (2010)
  • Author(s): 郷司翔、松井淳
  • Organizer: 日本化学会第90春季年会
  • Place of Presentation: 近畿大学(東大阪市)
  • Year and Date: 2010-03-28
• [Presentation] 含フッ素インプリントポリマーによるパーフルオロオクタン酸(PFOA)の認識 (2010)
  • Author(s): 高寄めぐみ、松井淳
  • Organizer: 日本化学会第90春季年会
  • Place of Presentation: 近畿大学(東大阪市)
  • Year and Date: 2010-03-28
• [Presentation] 8-ブロモデオキシグアノシンの導入によるトロンビン結合アプタマーの高次構造安定性及び親和性の向上 (2010)
  • Author(s): 郷司翔、松井淳
  • Organizer: 日本化学会第90春季年会
  • Place of Presentation: 大阪
  • Year and Date: 2010-03-28
• [Presentation] 含フッ素インプリントポリマーによるパーフルオロオクタン酸(PFOA)の認識 (2010)
  • Author(s): 高寄めぐみ、松井淳
  • Organizer: 日本化学会第90春季年会
  • Place of Presentation: 大阪
  • Year and Date: 2010-03-28
• [Presentation] Synthetic Receptor for a Fluorosurfactant PFOA Obtained by Molecular Imprinting (2010)
  • Author(s): Megumi Takayose, Jun Matsui
  • Organizer: The Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy
  • Place of Presentation: オーランド(米国)
  • Year and Date: 2010-03-01
• [Presentation] Synthetic receptor for a fluorosurfactant PFOA obtained by molecular imprinting (2010)
  • Author(s): Megumi Takayose, Jun Matsui
  • Organizer: The Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy
  • Place of Presentation: オーランド(米国)
  • Year and Date: 2010-03-01