| Project/Area Number |
21560781
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Properties in chemical engineering process/Transfer operation/Unit operation
|
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| Research Institution | Osaka City University |
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Principal Investigator |
OOSHIMA Hiroshi 大阪市立大学, 大学院・工学研究科, 教授 (20112526)
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| Co-Investigator(Renkei-kenkyūsha) |
IGARASHI Koichi 大阪市立大学, 大学院・工学研究科, 助教 (70315977)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 晶析 / 結晶核形成メカニズム / 粒径と粒径分布 / ナノ結晶 / 有機化合物結晶 / 医薬結晶 / マイクロ波照射 / 結晶核形成 / 2次核形成 / 有機結晶 / 連続晶析装置 / 溶液構造 / 多形制御 / マイクロ波照射晶析 / 微結晶の生成 / ナノ結晶の生成 / 結晶核発生 / 核形成メカニズム / 有機化合物の結晶 / 核発生 / 反復晶析 / 微結晶の晶析 |
|---|
| Research Abstract |
Chemical structure of pharmaceutical compounds evolves to become complex and hard to dissolve. To increase bioavailability of drugs, we must produce fine crystals of drugs by controlling the nucleation step of crystallization. However, the mechanism of nucleation has not been well understood. In the present study, we found for the first time that the control of the change of molecular associate structure and the control of diffusion of molecules are important to control nucleation. Furthermore, we attempted some processes to produce fine crystals.
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