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Analysis of subcellular region-specific signaling by Ras and Rho family GTPases

Research Project

Project/Area Number 21570138
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Functional biochemistry
Research InstitutionOsaka Prefecture University (2011)
Kobe University (2009-2010)

Principal Investigator

SATOH Takaya  大阪府立大学, 大学院・理学系研究科, 教授 (20251655)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywordsゲノム / 細胞・組織 / シグナル伝達 / 蛋白質 / Rac1 / インスリン / 糖取り込み / 骨格筋 / Racl / Rho / Rapl / 血管形成 / 中心体
Research Abstract

Ras and Rho family GTPases play an important role as a molecular switch in intracellular signal transduction. Recently, its subcellular region-specific regulatory mechanisms are featured. In this study, we analyzed the subcellular region-specific regulatory mechanism underlying newly identified signaling pathways involving the GTPase Rac1, RhoA, or Rap1.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (43 results)

All 2012 2011 2010 2009 Other

All Journal Article (13 results) (of which Peer Reviewed: 13 results) Presentation (19 results) Book (8 results) Remarks (3 results)

  • [Journal Article] RA-GEF-1(Rapgef2) is essential for proper development of the midline commissures2011

    • Author(s)
      Shymaa E. Bilasy, Takaya Satoh, Toshio Terashima, and Tohru Kataoka
    • Journal Title

      Neurosci. Res

      Volume: 71(3) Pages: 200-209

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] RA-GEF-1 (Rapgef2) is essential for proper development of the midline commissures2011

    • Author(s)
      Shymaa E.Bilasy
    • Journal Title

      Neurosci.Res.

      Volume: 71 Pages: 200-209

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crucial role of the small GTPase Rac1 in insulin-stimulated translocation of glucose transporter 4 to the mouse skeletal muscle sarcolemma2010

    • Author(s)
      Shuji Ueda, Sohei Kitazawa, Kota Ishida, Yuki Nishikawa, Megumi Matsui, Hikaru Matsumoto, Takuji Aoki, Shinsuke Nozaki, Tomoya Takeda, Yoshikazu Tamori, Atsu Aiba, C. Ronald Kahn, Tohru Kataoka, and Takaya Satoh
    • Journal Title

      FASEB J

      Volume: 24(7) Pages: 2254-2261

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Crucial role of the small GTPase Racl in insulin-stimulated translocation of glucose transporter 4 to the mouse skeletal muscle sarcolemma2010

    • Author(s)
      Shuji Ueda
    • Journal Title

      FASEB J.

      Volume: 24 Pages: 2254-2261

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crucial role of the small GTPase Rac1 in insulin-stimulated translocation of glucose transporter 4 to the mouse skeletal muscle sarcolemma2010

    • Author(s)
      Shuji Ueda
    • Journal Title

      FASEB J. (in press(掲載確定))

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mixed-lineage-leukemia(MLL) fusion protein collaborates with Ras to induce acute leukemia through aberrant Hox expression and Raf activation2009

    • Author(s)
      Ryoichi Ono, Hidetoshi Kumagai, Hideaki Nakajima, Ai Hishiya, Tomohiko Taki, Keisuke Horikawa, Kiyoshi Takatsu, Takaya Satoh, Yasuhide Hayashi, Toshio Kitamura, and Tetsuya Nosaka
    • Journal Title

      Leukemia

      Volume: 23(12) Pages: 2197-2209

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impaired vascular development in the yolk sac and allantois in mice lacking RA-GEF-12009

    • Author(s)
      Hoshimi Kanemura, Takaya Satoh, Shymaa E. Bilasy, Shuji Ueda, Masanori Hirashima, and Tohru Kataoka
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 387(4) Pages: 754-759

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of mitotic spindle formation by the RhoA guanine nucleotide exchange factor ARHGEF102009

    • Author(s)
      Takuji Aoki, Shuji Ueda, Tohru Kataoka, and Takaya Satoh
    • Journal Title

      BMC Cell Biol

      Volume: 10 Pages: 56-56

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dorsal telencephalon-specific RA-GEF-1 knockout mice develop heterotopic cortical mass and commissural fiber defect2009

    • Author(s)
      Shymaa E. Bilasy, Takaya Satoh, Shuji Ueda, Ping Wei, Hoshimi Kanemura, Atsu Aiba, Toshio Terashima, and Tohru Kataoka
    • Journal Title

      Eur. J. Neurosci

      Volume: 29(10) Pages: 1994-2008

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dorsal telencephalon-specific RA-GEF-1 knockout mice develop heterotopic cortical mass and commissural fiber defect2009

    • Author(s)
      Shymaa E.Bilasy
    • Journal Title

      Eur.J.Neurosci. 29

      Pages: 1994-2008

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of mitotic spindle formation by the RhoA guanine nucleotide exchange factor ARHGEF102009

    • Author(s)
      Takuji Aoki
    • Journal Title

      BMC Cell Biol. 10

      Pages: 56-56

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impaired vascular development in the yolk sac and allantois in mice lacking RA-GEF-12009

    • Author(s)
      Hoshimi Kanemura
    • Journal Title

      Biochem.Biophys.Res.Commun. 387

      Pages: 754-759

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mixed-lineage-leukemia(MLL)fusion protein collaborates with Ras to induce acute leukemia through aberrant Hox expression and Raf activation2009

    • Author(s)
      Ryoichi Ono
    • Journal Title

      Leukemia 23

      Pages: 2197-2209

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 骨格筋へのインスリン応答性糖取り込みにおけるRac1の機能解析2011

    • Author(s)
      野崎真輔, 武田朋也, 北浦拓也, 片岡徹, 佐藤孝哉
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-16
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] The Rap1 guanine nucleotide exchange factor RA-GEF-1 is essential for the proper development of the mouse cerebral cortex2011

    • Author(s)
      Kaori Nishihara, Shymaa E. Bilasy, Hironori Edamatsu, Toshio Terashima, Yuichi Ijiri, Takaya Satoh, and Tohru Kataoka
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-13
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Crucial role of the small GTPase Rac1 in insulin-stimulated translocation of glucose transporter 4 to the mouse skeletal muscle sarcolemma2011

    • Author(s)
      Shuji Ueda, Sohei Kitazawa, Kota Ishida, Yuki Nishikawa, Megumi Matsui, Hikaru Matsumoto, Takuji Aoki, Shinsuke Nozaki, Tomoya Takeda, Yoshikazu Tamori, Atsu Aiba, C. Ronald Kahn, Tohru Kataoka, and Takaya Satoh
    • Organizer
      2011 Annual Meeting of the American Society for Cell Biology
    • Place of Presentation
      Denver, CO, USA
    • Year and Date
      2011-12-04
    • Related Report
      2011 Final Research Report
  • [Presentation] Crucial role of the small GTPase Rac1 in insulin-stimulated translocation of glucose transporter 4 to the mouse skeletal muscle sarcolemma2011

    • Author(s)
      Shuji Ueda
    • Organizer
      2011 Annual Meeting of the American Society for Cell Biology
    • Place of Presentation
      アメリカ合衆国・コロラド州・デンバー
    • Year and Date
      2011-12-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] 大脳皮質の交連線維形成におけるグアニンヌクレオチド交換因子RA-GEF-1の機能2011

    • Author(s)
      寺島俊雄, シャイマー・ビラジィ, 薛富義, 佐藤孝哉, 片岡徹
    • Organizer
      第88回日本生理学会大会・第116回日本解剖学会総会・全国学術集会合同大会
    • Place of Presentation
      横浜
    • Year and Date
      2011-03-28
    • Related Report
      2011 Final Research Report
  • [Presentation] The Rap1 guanine nucleotide exchange factor RA-GEF-1 is essential for the proper development of the mouse dorsal telencephalon2011

    • Author(s)
      Shymaa E. Bilasy, Takaya Satoh, Toshio Terashima, and Tohru Kataoka
    • Organizer
      31st Annual Meeting of the Australian Neuroscience Society
    • Place of Presentation
      Auckland, New Zealand
    • Year and Date
      2011-02-03
    • Related Report
      2011 Final Research Report
  • [Presentation] The Rap1 guanine nucleotide exchange factor RA-GEF-1 is essential for the proper development of the mouse dorsal telencephalon.2011

    • Author(s)
      Shymaa E.Bilasy
    • Organizer
      31st Annual Meeting of the Australian Neuroscience Society
    • Place of Presentation
      Auckland (New Zealand)
    • Year and Date
      2011-02-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 骨格筋へのインスリン応答性糖取り込みにおけるRac1の機能解析2010

    • Author(s)
      野崎真輔, 武田朋也, 北浦拓也, 片岡徹, 佐藤孝哉
    • Organizer
      第83回日本生化学会大会・第33回日本分子生物学会年会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-10
    • Related Report
      2011 Final Research Report
  • [Presentation] The Rap1 guanine nucleotide exchange factor RA-GEF-1 is essential for the proper development of the mouse cerebral cortex2010

    • Author(s)
      Shymaa E. Bilasy, Takaya Satoh, Toshio Terashima, and Tohru Kataoka
    • Organizer
      第83回日本生化学会大会・第33回日本分子生物学会年会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-10
    • Related Report
      2011 Final Research Report
  • [Presentation] The Rap1 guanine nucleotide exchange factor RA-GEF-1 is essential for the proper development of the mouse cerebral cortex.2010

    • Author(s)
      Shymaa E.Bilasy
    • Organizer
      第83回日本生化学会大会・第33回日本分子生物学会年会合同大会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Year and Date
      2010-12-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] 骨格筋へのインスリン応答性糖取り込みにおけるRac1の機能解析.2010

    • Author(s)
      野崎真輔
    • Organizer
      第83回日本生化学会大会・第33回日本分子生物学会年会合同大会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Year and Date
      2010-12-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] The Rap1 guanine nucleotide exchange factor RA-GEF-1 is essential for the proper development of the mouse cerebral cortex2010

    • Author(s)
      Shymaa E. Bilasy, Takaya Satoh, Toshio Terashima, and Tohru Kataoka
    • Organizer
      第33回日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-04
    • Related Report
      2011 Final Research Report
  • [Presentation] The Rap1 guanine nucleotide exchange factor RA-GEF-1 is essential for the proper development of the mouse cerebral cortex.2010

    • Author(s)
      Shymaa E.Bilasy
    • Organizer
      第33回日本神経科学大会
    • Place of Presentation
      神戸コンベンションセンター(兵庫県)
    • Year and Date
      2010-09-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] Regulation of mitotic spindle formation by the RhoA guanine nucleotide exchange factor ARHGEF102009

    • Author(s)
      Takuji Aoki, Shuji Ueda, Tohru Kataoka, and Takaya Satoh
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-10
    • Related Report
      2011 Final Research Report
  • [Presentation] Regulation of mitotic spindle formation by the RhoA guanine nucleotide exchange factor ARHGEF102009

    • Author(s)
      Takuji Aoki
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2009-12-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] マウス胎生期の血管形成におけるRA-GEF-1の機能解析2009

    • Author(s)
      金村星余, 佐藤孝哉, 上田修司, Shymaa E. Bilasy, 平島正則, 片岡徹
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2009-10-22
    • Related Report
      2011 Final Research Report
  • [Presentation] マウス胎生期の血管形成におけるRA-GEF-1の機能解析2009

    • Author(s)
      金村星余
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Year and Date
      2009-10-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] 背側終脳特異的RA-GEF-1ノックアウトマウスは大脳皮質ヘテロトピアと交連線維系の欠損を示す2009

    • Author(s)
      寺島俊雄, Shymaa E. Bilasy, 佐藤孝哉, 上田修司, Ping Wei, 金村星余, 饗場篤, 片岡徹
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-16
    • Related Report
      2011 Final Research Report
  • [Presentation] 背側終脳特異的RA-GEF-1ノックアウトマウスは大脳皮質ヘテロトピアと交連線維系の欠損を示す2009

    • Author(s)
      寺島俊雄
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2009-09-16
    • Related Report
      2009 Annual Research Report
  • [Book] Encyclopedia of Signaling Molecules2012

    • Author(s)
      Takaya Satoh
    • Publisher
      Springer(印刷中)
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Book] 低分子量Gタンパク質2012

    • Author(s)
      佐藤孝哉
    • Publisher
      羊土社(印刷中)
    • Related Report
      2011 Final Research Report
  • [Book] デブリン生化学(第7版)2012

    • Author(s)
      佐藤孝哉
    • Related Report
      2011 Final Research Report
  • [Book] キーワードで理解するシグナル伝達イラストマップ(改訂版)2012

    • Author(s)
      佐藤孝哉
    • Publisher
      羊土社(印刷中)
    • Related Report
      2011 Annual Research Report
  • [Book] シグナル伝達.生命システムの情報ネットワーク.(第2版)2011

    • Author(s)
      佐藤孝哉
    • Related Report
      2011 Final Research Report
  • [Book] シグナル伝達-生命システムの情報ネットワーク-(第2版)(翻訳)2011

    • Author(s)
      上代淑人, 佐藤孝哉監訳
    • Total Pages
      678
    • Publisher
      メディカル・サイエンス・インターナショナル
    • Related Report
      2011 Annual Research Report
  • [Book] Encyclopedia of Signaling Molecules2011

    • Author(s)
      Takaya Satoh
    • Publisher
      Springer(未定)
    • Related Report
      2010 Annual Research Report
  • [Book] シグナル伝達-生命システムの情報ネットワーク-(第2版)(翻訳)2011

    • Author(s)
      上代淑人, 佐藤孝哉 監訳
    • Publisher
      メディカル・サイエンス・インターナショナル(未定)
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.b.s.osakafu-u.ac.jp/

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.med.kobe-u.ac.jp/molbiol/index.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.kobe-u.ac.jp/molbiol/index.html

    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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