Regulatory mechanism of glycosylation
| Project/Area Number |
21570157
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Keio University (2010-2011)
Mitsubishi Kagaku Institute of Life Sciences (2009) |
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Principal Investigator |
GOTO Satoshi 慶應義塾大学, 医学部, 特任講師 (60280575)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
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| Keywords | 糖鎖 / mRNA / ショウジョウバエ / 翻訳後修飾 / 小胞体 / 核外輸送 / 転写 |
|---|
| Research Abstract |
Glycosylation plays an important role in various physiological processes such as development, immunity and neural functions. However, mechanisms regulating glycosylation still remain largely unknown. To elucidate it, we performed a large scale screen using Drosophila RNAi library and identified novel genes. We analyzed the functions of the genes and found novel mechanisms of mRNA of glycosylation related genes.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Identification of proteasome components required for apical localization of Chaoptin using functional genomics2012
Author(s)
Yano, H., Yamamoto-Hino, M., Awano, W., Aoki-Kinoshita, K. F., Tsuda-Sakurai, K., Okano, H. and Goto, S.
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Journal Title
J. Neurogenet
Volume: vol.26
Issue: 1
Pages: 53-63
DOI
Related Report
Peer Reviewed
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[Journal Article] Identification of genes required for neural-specific glycosylation using functional genomics2010
Author(s)
Yamamoto-Hino, M., Kanie, Y., Awano, W., Aoki-Kinoshita, K. F., Yano, H., Nishihara, S., Okano, H., Ueda, R., Kanie, O. and Goto, S.
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Journal Title
PLoS Genetics
Volume: vol.6
Issue: 12
Pages: e1001254-e1001254
DOI
Related Report
Peer Reviewed
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[Journal Article] Insight into the regulation of glycan synthesis in Drosophila chaoptin based on mass spectrometry2009
Author(s)
Kanie, Y., Yamamoto-Hino, M., Karino, Y., Yokozawa, H., Nishihara, S., Ueda, R., Goto, S. and Kanie, O.
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Journal Title
PLoS ONE
Volume: vol.4
Issue: 5
Pages: e5434-e5434
DOI
Related Report
Peer Reviewed
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[Book] NY, Structure, Function and Formation of Glycans in Drosophila, Glycans : Biochemistry, Characterization and Applications.2012
Author(s)
Yamamoto-Hino, M., Okano, H., Kanie, O. and Goto, S.
Publisher
Nova Science publishers, Inc.
Related Report
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[Book] Structure, Function and Formation of Glycans in Drosophila. In "Glycans : Biochemistry, Characterization and Applications."2012
Author(s)
Yamamoto-Hino, M., Okano, H., Kanie, O., Goto, S.
Publisher
Nova Science publishers, Inc., NY
Related Report
