Search for New Cancer Cell Growth Pathway

• Project/Area Number: 21570191
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Molecular biology
• Research Institution: National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
• Principal Investigator: OHTA Tsutomu 独立行政法人国立がん研究センター, 研究所, ユニット長 (10290892)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 転写 / DNAチップ解析 / 細胞増殖 / 癌細胞

Research Abstract

The lung cancer is one of intractable cancers, and a tendency to increase has the death rate, the prevalence. Therefore I searched for the new system that participated in cell proliferation of the lung cancer. As a result, I identified that the protein called the transcription factor played an important role in lung cancer cell proliferation. Furthermore, I analyzed the gene expression in tissues and cell lines of breast cancer. As a result, I identified that the protein called the DNA replication factor played an important role in breast cancer cell proliferation.

Research Products

• [Journal Article] Up-regulation of PSF1 Promotes the Growth of Breast Cancer Cells (2010)
  • Author(s): Nakahara I, Miyamoto M, Shibata T, Akashi-Tanaka S, Mogushi K, Oda K, Ueno M, Takakura N, Mizushima H, Tanaka H, and Ohta T
  • Journal Title: Genes Cells Volume: 15 Issue: 10 Pages: 1015-1024
  • DOI: 10.1111/j.1365-2443.2010.01442.x
• [Journal Article] Up-regulation of PSF1 Promotes the Growth of Breast Cancer Cells. (2010)
  • Author(s): 中原泉
  • Journal Title: Genee Celle Volume: 15 Pages: 1015-1024
  • Peer Reviewed
• [Presentation] Molecular Analysis of Synovial Sarcoma(滑膜肉腫発症機構の解明) (2011)
  • Author(s): 大野(宮本)麻美子、太田力
  • Organizer: 第70回日本癌学会学術総
  • Place of Presentation: 名古屋
  • Year and Date: 2011-09-03
• [Presentation] 網羅的遺伝子発現解析を用いた抗がん剤抵抗性機構の解明 (2010)
  • Author(s): 太田力
  • Organizer: 第33回日本分子生物学会年会、第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-14
• [Presentation] Constitutive activation of Nrf2 provides advantages for lung cancer cell growth (2010)
  • Author(s): 宮本麻美子、太田力
  • Organizer: 第69回日本癌学会学術総
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-07
• [Presentation] Double-edged Sword of the Nrf2-Keap1 stress Response System : Carcinogenesis and Cancer Chemoprevention (2009)
  • Author(s): 山本雅之、柴田龍弘、太田力、Kit Tong,黒河博文、鈴木貴史、田口恵子、本橋ほずみ
  • Organizer: 第68回日本癌学会学術総
  • Place of Presentation: 横浜
  • Year and Date: 2009-09-09
• [Presentation] Comprehensive analysis of new therapeutic targeting gene in Breast Cancer (2009)
  • Author(s): 中原泉,柴田龍弘,鈴木華絵,水島洋,上野将也,高倉伸幸,田中博,太田力
  • Organizer: 第68回日本癌学会学術総
  • Place of Presentation: 横浜
  • Year and Date: 2009-09-08
• [Remarks]
  • URL: http://www.ncc.go.jp/jp/nccri/divisions/omics_bioinformatics/omics_bioinformatics.html
• [Remarks]
  • URL: http://www.ncc.go.jp/jp/nccri/divisions/omics_bioinformatics/omcs_bioinformatics.html
• [Remarks]
  • URL: http://www.ncc.go.jp/jp/nccri/divisions/omics_bioinformatics/omics_bioinformatics.html
• [Remarks]
  • URL: http://www.ncc.go.jp/jp/nccri/index.html