| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
Methylglyoxal(MG) is an endogenous metabolite in glycolysis and forms stable adducts, argpyrimidine, primarily with arginine residues of intracellular proteins. The biological role of this modification in cell function is not known. In the present study, we found that a subunit of chromatin remodeling complex forms the argpyrimidine and revealed that the subunit has a critical role of neural differentiation.
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