Molecular basis for the regulation of placode differentiation

• Project/Area Number: 21570215
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Developmental biology
• Research Institution: Tohoku University
• Principal Investigator: WAKAMATSU Yoshio 東北大学, 大学院・医学系研究科, 講師 (60311560)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 器官形成 / 感覚器 / 神経 / 細胞分化 / 遺伝子 / プラコード / 分化 / シグナル伝達

Research Abstract

Molecular mechanisms of placode fate determination in vertebrates were studied. The involvement of FGF and BMP signalings were shown in cultured tissues. Furthermore, the requirement of mutual repression between Pax3 and Pax6 genes in trigeminal placode development were also revealed.

Research Products

• [Journal Article] Mutual repression between Pax3 and Pax6 is involved in the positioning of ophthalmic trigeminal placode in avian embryo (2011)
  • Author(s): Wakamatsu Y
  • Journal Title: Development Growth and Differentiation Volume: 53 Pages: 994-1003
  • NAID: 10030404195
  • Peer Reviewed
• [Journal Article] Role of paraxial mesoderm in limb/flank regionalization of the trunk lateral plate (2011)
  • Author(s): Noro M, Yuguchi H, Tsuihiji T, Yonei-Tanura S, Yokoyama H, Wakamatsu Y, Tamura K.
  • Journal Title: Developmental Dynamics Volume: 240 Pages: 1639-1649
  • Peer Reviewed
• [Journal Article] FilaminB is required for the directed localization of cell-cell adhesion molecules in embryonic epithelial development (2011)
  • Author(s): Wakamatsu Y, Sakai D, Suzuki T, Osumi N
  • Journal Title: Developmental Dynamics Volume: 240 Pages: 149-161
  • Peer Reviewed
• [Journal Article] Mutual repression between pax3 and Pax6 is involved in the positioning of ophthalmic trigeminal placode in avian embryo (2011)
  • Author(s): Wakamatsu Y
  • Journal Title: Development, Growth & Differentiation Volume: 53 Issue: 9 Pages: 994-1003
  • DOI: 10.1111/j.1440-169x.2011.01311.x
  • NAID: 10030404195
  • Peer Reviewed
• [Journal Article] FilaminB is required for the directed localization of cell-cell adhesion molecules in embryonic epithelial development. (2011)
  • Author(s): Wakamatsu, Y., Sakai, D., Suzuki, T., Osumi, N
  • Journal Title: Developmental Dynamics Volume: 240 Pages: 149-161
  • Peer Reviewed
• [Journal Article] Stabilization of ATF4 protein is required for the regulation of epithelial-mesenchymal transition of the avian neural crest (2010)
  • Author(s): Suzuki T, Osumi N, Wakamatsu Y
  • Journal Title: Developmental Biology Volume: 344 Pages: 658-668
  • Peer Reviewed
• [Journal Article] Dynamic expression of Six family genes in the dental mesenchyme and the epithelial ameloblast stem/progenitor cells during murine tooth development (2010)
  • Author(s): Nonomura K, Takahashi M, Wakamatsu Y, Takano-Yamamoto T, Osumi N
  • Journal Title: Journal of Anatomy Volume: 216 Pages: 80-91
  • Peer Reviewed
• [Journal Article] Stabilization of ATF4 protein is required for the regulation of epithelial-mesenchymal transition of the avian neural crest. (2010)
  • Author(s): Suzuki, T., Osumi, N., Wakamatsu, Y.
  • Journal Title: Developmental Biology Volume: 344 Pages: 658-668
  • Peer Reviewed
• [Journal Article] Dynamic expression of Six family genes in the dental mesenchyme and the epithelial ameloblast stem/progenitor cells during murine tooth development (2010)
  • Author(s): Nonomura, K., Takahashi, M., Wakamatsu, Y., et al.
  • Journal Title: Journal of Anatomy 216 Pages: 80-91
  • Peer Reviewed
• [Journal Article] Overlapped and differential expression of PKA-inhibitor isoforms during avian organogenesis period (2009)
  • Author(s): Wakamatsu Y
  • Journal Title: Development Growth and Differentiation Volume: 51 Pages: 707-714
  • Peer Reviewed
• [Journal Article] Overlapped and differential expression of PKA-inhibitor isoforms during avian organogenesis period (2009)
  • Author(s): Wakamatsu, Y.
  • Journal Title: Development, Growth & Differentiation 51 Pages: 707-714
  • Peer Reviewed
• [Presentation] Fattiy acid binding protein (Fabp7)is involved in the maintenance of neural stem/progenitor cells, survival of neurons and maturation of astrocytes (2011)
  • Author(s): Tashiro R, Sakayori N, Matsumata M, Owada Y, Wakamatsu Y, Osumi N
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-16
• [Presentation] Fatty acid binding protein (Fabp7) is involved in the maintenance of neural stem/progenitor cells, survival of neurons and maturation of astrocytes (2011)
  • Author(s): Tashiro R, Sakayori N, Matsumata M, Owada Y, Wakamatsu Y, Osumi N
  • Organizer: 日本神経科学会第34回大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-16
• [Presentation] Mutual repression of Pax3 and Pax6 deermines the lateral border of the trigeminal placode (2011)
  • Author(s): Wakamatsu Y
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-15
• [Presentation] The adherens junction serves as a switch for neurogenesis by facilitating Notch-delta interaction in vertebrate (2011)
  • Author(s): Hatakeyama J, Wakamatsu Y. Shigemoto R, Shimamura K
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-15
• [Presentation] The adherens junction serves as a switch for neurogenesis by facilitating Notch-Delta interaction in vertebrate (2011)
  • Author(s): Hatakeyama J, Wakamatsu Y, Shigemoto R, Shimamura K
  • Organizer: 日本神経科学会第34回大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-15
• [Presentation] Mutual repression of PPax3 and Pax6 determines the lateral border of the trigeminal placode (2011)
  • Author(s): Wakamatsu Y
  • Organizer: 日本神経科学会第34回大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-15
• [Presentation] Molecular basis for the heterochronic development of marsupial cranial neural crest (2011)
  • Author(s): Wakamatsu Y. Osumi N, Suzuki K
  • Organizer: 日本発生生物学会第44回大会
  • Place of Presentation: 沖縄
  • Year and Date: 2011-05-19
• [Presentation] Molecular basis for heterochronic development of marsupial neural crest (2011)
  • Author(s): Wakamatsu Y, Osumi N, Suzuki K
  • Organizer: 日本発生生物学会第44回大会
  • Place of Presentation: 沖縄宜野湾市
  • Year and Date: 2011-05-19
• [Presentation] 神経堤細胞の上皮-間充織転換におけるタンパク質分解制御の役割 (2010)
  • Author(s): 若松義雄
  • Organizer: Neuro2010
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-04
• [Presentation] Regulatory roles of protein degradation in the neural crest epithelial-mesenchymal transition (2010)
  • Author(s): Wakamatsu Y
  • Organizer: Neuro2010
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-03
• [Presentation] Stability control of ATF4 protein is involved in the promotion of neural crest EMT (2010)
  • Author(s): Wakamatsu Y, Suzuki T, Osumi N
  • Organizer: 2010 SDB-JSDB Joint Meeting
  • Place of Presentation: アルバカーキ、USA
  • Year and Date: 2010-08-07
• [Presentation] Stability control of ATF4 protein is involved in the promotion of neuralcrest EMT (2010)
  • Author(s): 若松義雄、鈴木享、大隅典子
  • Organizer: Developmental Biology 69^<th> Annual Meeting
  • Place of Presentation: Albuquerque, USA
  • Year and Date: 2010-08-07
• [Presentation] 培養神経板のプラコードへの形質転換実験系を用いたプラコードサブタイプの決定メカニズムの解析 (2010)
  • Author(s): 若松義雄
  • Organizer: 日本発生生物学会第43回大会
  • Place of Presentation: 京都
  • Year and Date: 2010-06-22
• [Presentation] In vitro transformation from neural plate to placode provides mechanisticinsights into placode subtype specification (2010)
  • Author(s): 若松義雄
  • Organizer: 日本発生生物学会第43回大会
  • Place of Presentation: 京都
  • Year and Date: 2010-06-21
• [Presentation] プラコード個性決定の制御機構の解明 (2010)
  • Author(s): 若松義雄
  • Organizer: 日本分子生物学会第10回春季シンポジウム
  • Place of Presentation: 松島
  • Year and Date: 2010-06-07
• [Presentation] ATF4による神経堤細胞の上皮-間充織転換の制御 (2010)
  • Author(s): 若松義雄
  • Organizer: 日本分子生物学会第10回春季シンポジウム
  • Place of Presentation: 松島
  • Year and Date: 2010-06-07