Dorsoventral patterning mechanism in vertebrate late development
| Project/Area Number |
21570219
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Developmental biology
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
SHIMADA Atsuko 東京大学, 大学院・理学系研究科, 助教 (20376552)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | メダカ / Da / 背腹パターン / zic / 後期発生 / Da変異体 / 体節 / 発生後期 / Zic遺伝子 / 外部形態 / 脊椎動物 |
|---|
| Research Abstract |
Vertebrates exhibit remarkable dorsoventral (DV) asymmetries in coloration and body shape. A medaka mutant Da exhibits a unique ventralized phenotype of the overall trunk morphology from late to adult stages and provides a good experimental model to investigate these late mechanisms. We show by tissue transplantation that somite-derived tissues patterned by zic1/zic4 determine the external characteristics (morphology and coloration) through long-term epithelial-mesenchymal interaction and that zic1/zic4 expression persists to the adult stage and unveils a novel dorsal domain, suggesting a continuous requirement of these genes for the maintenance of dorsal identities.
|
Report
(4 results)
Research Products
(27 results)
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Mesodermal origin of scales and fins of fish- Insight into origin and evolution of mineralized skeleton in vertebrates2011
Author(s)
Shimada, A., Kawanishi, T., Kaneko, T., Yoshihara, H., Yano, T., Inohaya, K., Kamei, Y., Kinoshita, M., Tamura, K., Takeda, H.
Organizer
第44回日本発生生物学会大会
Place of Presentation
宜野湾
Related Report
-
-
-
-
-
-
[Presentation] The zic genes as master regulators in dorsoventral patterning of the fish trunk structures2010
Author(s)
Moriyama, Y., Nakamura, R., Kawanishi, T., Shimada, A., Takeda, H.
Organizer
2nd Joint Meeting of the SFBD and JSDB
Place of Presentation
Paris, France
Related Report
-
-
[Presentation] zic1 and zic4 expression in the somite regulates dorsalization of the fish trunk structures2010
Author(s)
Kawanishi, T., Moriyama, Y. , Nakamura, R., Shimada, A., Takeda, H.
Organizer
2010 SDB-JSDB Joint Meeting, Albuquerque
Place of Presentation
U.S.A.
Related Report
-
-
[Presentation] Analysis of mechanisms underlying the development of the external morphology using the medaka mutant, Double anal fin (Da) - Analysis of the somite-specific enhancer of the zic genes in medaka: toward understanding of the evolution of the the external morphology in vertebrates2009
Author(s)
Moriyama, Y., Shimada, A., Naruse, K., Fujiyama, A., Toyoda, A., Takeda, H.
Organizer
第32回日本分子生物学会年会
Place of Presentation
横浜
Related Report
-
-
-
-
[Presentation] Analysis of the somite-specific enhancer of the zic genes in medaka: toward understanding of the evolution of the the external morphology in vertebrates2009
Author(s)
Moriyama,Y., Shimada, A., Naruse, K., Fujiyama, A., Toyoda, A., Takeda, H.
Organizer
第42回日本発生生物学会
Place of Presentation
新潟
Related Report
-
