Analyses on molecular mechanism of animal-type cytokinesis, substrate adhesion and interaction between these functions
| Project/Area Number |
21580085
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied microbiology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
ADACHI Hiroyuki 東京大学, 大学院・農学生命科学研究科, 准教授 (00211699)
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| Research Collaborator |
INABA Hironori 東京大学, 大学院・農学生命科学研究科
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 微生物 / 細胞質分裂 / 細胞性粘菌 |
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| Research Abstract |
Eukaryotic microorganism, Dictyostelium discoideum is a model for studying cellular motility of animal-type cells. D411-2p, found by the principal researcherof this work and others, was found to bind and bundle actin filaments, the main player ofcellular motility, and also to be involved in substrate adhesion. On the other hand, usingGFP, subcellular localization of six of eleven Dictyostelium Dibs, proteins corresponding tobeta integrins in animal cells, was determined to be plasma membrane in most cases andunidentified organelle in two cases. These two cellular functions are thought to affect eachother through interactions among proteins on plasma membrane.
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Report
(4 results)
Research Products
(12 results)
