| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
Eukaryotic microorganism, Dictyostelium discoideum is a model for studying cellular motility of animal-type cells. D411-2p, found by the principal researcherof this work and others, was found to bind and bundle actin filaments, the main player ofcellular motility, and also to be involved in substrate adhesion. On the other hand, usingGFP, subcellular localization of six of eleven Dictyostelium Dibs, proteins corresponding tobeta integrins in animal cells, was determined to be plasma membrane in most cases andunidentified organelle in two cases. These two cellular functions are thought to affect eachother through interactions among proteins on plasma membrane.
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