Anti-stress amino acids and its mechanisms in muscle atrophy
Project/Area Number |
21580134
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Food science
|
Research Institution | Iwate University |
Principal Investigator |
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | アミノ酸 / 骨格筋 / タンパク質分解 / タンパク質合成 / シトルリン / リジン / トリプトファン / 廃用性筋萎縮 / 低栄養 / 骨格筋萎縮 / ロイシン / 一酸化窒素 / 尾部懸垂 / ユビキチン-プロテアソーム / サルコペニア |
Research Abstract |
Muscle atrophy in aging causes decreased QOL. In this study, suppression of muscle atrophy with decrease in protein degradation and increase in protein synthesis by amino acids named anti-stress amino acids. Taurine had no effects on muscle protein turnover, however citrulline and tryptophan showed to suppress muscle atrophy. In particular, citrulline had unique effects on muscle protein turnover.
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Report
(4 results)
Research Products
(16 results)