| Project/Area Number |
21580150
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Okayama Prefectural University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KIMOTO Masumi 岡山県立大学, 保健福祉学部, 教授 (40108866)
TAKAHASHI Yoshitaka 岡山県立大学, 保健福祉学部, 教授 (10236333)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | メタボリックシンドローム / 脂質代謝 / 食品 / 酢酸 / 細胞・組織 / 脂肪代謝 / 肥満 / AMPK / 血管内皮細胞 / eNOS / マクロファージ / 内臓脂肪細胞 / 3T3-L1細胞 / IL-6 / TNF-α / 筋管細胞 / GLUT4 / ミオグロビン |
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| Research Abstract |
Previously, we reported that oral administrated acetate contributed to suppression of lipogenesis in the liver, to the reduction of lipid accumulation in adipose tissue, and to the improvement of glucose tolerance of Otsuka Long-Evans Tokushima Fatty(OLETF) rats. Acetate has a potential for prevention of metabolic syndrome. In this study, we investigated the effect of acetate on skeletal muscle and adipose tissue. It was shown that acetate stimulated expressions of myoblobin and GLUT4 via activation of AMP-activated protein kinase(AMPK) and it enhanced fatty acid metabolism and glucose uptake in skeletal muscle.
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