| Project/Area Number |
21580386
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Clinical veterinary science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
NISHIMURA Ryohei 東京大学, 大学院・農学生命科学研究科, 教授 (80172708)
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| Co-Investigator(Kenkyū-buntansha) |
NAGAHAMA Shotaro 東京大学, 大学院・農学生命科学研究科, 助教 (70456177)
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| Co-Investigator(Renkei-kenkyūsha) |
HORI Masatoshi 東京大学, 大学院・農学生命科学研究科, 准教授 (70211547)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | モルヒネ / フェンタニル / レミフェンタニル / 犬 / 猫 / 薬物動態 / 薬力学 / 鎮痛作用 / オピオイド / MAC-BAR / 侵害刺激 / コルチゾール / 血中濃度 / 高速液体クロマトグラフィー / 固相抽出法 / 代謝産物 / M3G |
|---|
| Research Abstract |
Opioids induced dose-dependent antinociceptive effect and depression of conscious level, activity and heart rate and respiratory rate in dogs. In contrast, opioids induced weak antinociceptive effect and less depression of conscious level, activity, heart rate and respiratory rate even at higher dose of opioids in cats. Results of pharmacokinetic analysis have indicated that this pharmacodynamics difference is not caused by pharmacokinetic difference mainly, but rather by difference of the opioid receptor distribution or function.
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