Development of high performance or ganocatalyst using a-hetero atom effects and its application to enantioselective Biginelli reaction
| Project/Area Number |
21590010
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Hiroshima University |
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Principal Investigator |
SUZUKI Ichiro 広島大学, 大学院・医歯薬学総合研究科, 准教授 (40294714)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | Biginelli反応 / 有機触媒 / 不斉Diels. Alder反応 / α.ヘテロ原子効果 / 有機分子触媒 / 不斉Diels-Alder反応 / 分子軌道計算 / イミニウムイオン / ヒドラジド / α-ヘテロ原子効果 / ビギネリ反応 / 不斉有機触媒 / ヒドラジン |
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| Research Abstract |
We investigated enantioselective Biginelli reactions using hydrazine. and Hydrazide. based organocatalyst. We found that a chiral pyrazolidine-based catalyst showed only low efficiency, whereas parent pyrazolidine showed high catalytic performance. We further developed diamino oxazolidinone type organocatalysts and found that these catalysts showed high efficiency in enantioselective Diels-Alder reactions.
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Report
(4 results)
Research Products
(36 results)
