| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Research Abstract |
The synthesis of the decalin and succinimide portions of the p21^<ras> farnecyltransferase inhibitor TAN-1813(antitumor substance) were efficiently achieved. In additions, two novel spiruchostatin analogs, spiruchostatin C and D(histone deacetylase inhibitors as molecular-targeted anticancer agents) were accomplished. Their biological evaluation revealed that spiruchostatins C and D are promising candidates for the development of novel anticancer agents.
|
