Synthetic Studies on Biologically Active Natural Products Aiming at Developing Novel Molecular-Targeted Agents
| Project/Area Number |
21590018
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tohoku Pharmaceutical University |
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Principal Investigator |
KATOH Tadashi 東北薬科大学, 薬学部, 教授 (50382669)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Kazuhiro 東北薬科大学, 薬学部, 講師 (10382673)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 合成化学 / 抗がん剤 / 免疫抑制剤 / 創薬化学 / TAN-1813 / スピルコスタチン類 / FK228 / 分子標的治療薬 / 生物活性天然物 / 抗腫瘍活性物質 / 全合成 / HDAC阻害剤 / スピルコスタチン / p21^<ras>ファルネシルトランスフェラーゼ阻害剤 / 抗の腫瘍活性物質 |
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| Research Abstract |
The synthesis of the decalin and succinimide portions of the p21^<ras> farnecyltransferase inhibitor TAN-1813(antitumor substance) were efficiently achieved. In additions, two novel spiruchostatin analogs, spiruchostatin C and D(histone deacetylase inhibitors as molecular-targeted anticancer agents) were accomplished. Their biological evaluation revealed that spiruchostatins C and D are promising candidates for the development of novel anticancer agents.
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Report
(4 results)
Research Products
(59 results)
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[Journal Article] Total Synthesis of the Bicyclic Depsipeptide HDAC Inhibitors Spiruchostatins A and B, 5''-epi-Spiruchostatin B, FK228(FR901228) and Preliminary Evaluation of Their Biological Activity2009
Author(s)
Koichi Narita, Takuya Kikuchi, Kazuhiro Watanabe, Toshiya Takizawa, Takamasa Oguchi, Kyosuke Kudo, Keisuke Matsuhara, Hideki Abe, Takao Yamori, Minoru Yoshida, Tadashi Katoh
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Journal Title
Chem. Eur. J.
Volume: 15巻
Issue: 42
Pages: 11174-11186
DOI
Related Report
Peer Reviewed
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[Journal Article] Total Synthesis of the Bicyclic Depsipeptide HDAC Inhibitors Spiruchostatins A and B, 5"-epi-Spiruchostatin B, FK228 (FR901228) and Preliminary Evaluation of Their Biological Activity2009
Author(s)
Koichi Narita, Takuya Kikuchi, Kazuhiro Watanabe, Toshiya Takizawa, Takamasa Oguchi, Kyosuke Kudo, Keisuke Matsuhara, Hideki Abe, Takao Yamori, Minoru Yoshida, Tadashi katoh
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Journal Title
Chem.Eur.J. 15
Pages: 11174-11186
Related Report
Peer Reviewed
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[Presentation] Synthetic Study of Kopsia Alkaloid Lapidilectine B2010
Author(s)
Hideki Abe, Takuya Kikuchi, Kazuhiro Watanabe, Sakae Aoyagi, Chihiro Kibayashi, Tadashi Katoh, Hisanaka Ito
Organizer
2010 International Chemical Congress of Pacific Basin Societies(PACIFICHEM 2010)
Place of Presentation
Honolulu
Year and Date
2010-12-19
Related Report
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[Presentation] Synthetic Study of Kopsia Alkaloid Lapidilectine B2010
Author(s)
Hideki Abe, Takuya Kikuchi, Kazuhiro Watanabe, Sakae Aoyagi, Chihiro Kibayashi, Tadashi Katoh, Hisanaka Ito
Organizer
2010 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010)
Place of Presentation
Honolulu
Year and Date
2010-12-19
Related Report
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