Synthesis of Novel Nucleoside Derivatives Applicable to Nucleic Acids Medicine
Project/Area Number |
21590119
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Drug development chemistry
|
Research Institution | Tohoku Pharmaceutical University |
Principal Investigator |
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | ヌクレオシド / 抗HIV活性 / 光延反応 / Pummerer反応 / イソヌクレオシド / 炭素環ヌクレオシド / 閉環メタセシス反応 / 核酸医薬 / ジヒドロチオピラン / グリコシル化 |
Research Abstract |
To develop nucleoside derivatives applicable to nucleic acids medicine with high affinity and stability and to search new anti-HIV agents, we designed and synthesized novel nucleoside derivatives. The target compounds were nucleosides having 2, 6-dioxabicyclo[3.2.0] heptane, dihydropyran and dihydrothiopyran derivatives as pseudosugar moieties. Among the compounds synthesized, dihydrothiopyranylcytosine showed significant anti-HIV activity.
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Report
(4 results)
Research Products
(31 results)