Systemic vascular disorders in chronic kidney disease and screening for protective drugs
Project/Area Number |
21590172
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Medical pharmacy
|
Research Institution | Nagoya City University |
Principal Investigator |
ONO Takahiko 名古屋市立大学, 大学院・薬学研究科, 客員教授 (60243028)
|
Co-Investigator(Kenkyū-buntansha) |
MAKINO Toshiaki 名古屋市立大学, 大学院・薬学研究科, 准教授 (80326561)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 慢性腎臓病(CKD) / 七物降下湯 / Asymmetric dimethylarginine / 釣藤鈎 / 漢方薬 / connective tissue growth factor |
Research Abstract |
We investigated effects of shichimotsukokato(SKT) on renal hypertension in rats subjected to a 5/6 nephrectomy(Nx). SKT significantly counteracted the increase in systolic blood pressure and plasma asymmetric dimethylarginine(ADMA) levels, and the decrease in plasma NO levels and renal dimethylarginine dimethylaminohydrolase(DDAH)-2 levels. It is considered that SKT reduced blood pressure mediated by the DDAH/ADMA/NO pathway.
|
Report
(4 results)
Research Products
(17 results)