Systemic vascular disorders in chronic kidney disease and screening for protective drugs

• Project/Area Number: 21590172
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Medical pharmacy
• Research Institution: Nagoya City University
• Principal Investigator: ONO Takahiko 名古屋市立大学, 大学院・薬学研究科, 客員教授 (60243028)
• Co-Investigator(Kenkyū-buntansha): MAKINO Toshiaki 名古屋市立大学, 大学院・薬学研究科, 准教授 (80326561)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 慢性腎臓病(CKD) / 七物降下湯 / Asymmetric dimethylarginine / 釣藤鈎 / 漢方薬 / connective tissue growth factor

Research Abstract

We investigated effects of shichimotsukokato(SKT) on renal hypertension in rats subjected to a 5/6 nephrectomy(Nx). SKT significantly counteracted the increase in systolic blood pressure and plasma asymmetric dimethylarginine(ADMA) levels, and the decrease in plasma NO levels and renal dimethylarginine dimethylaminohydrolase(DDAH)-2 levels. It is considered that SKT reduced blood pressure mediated by the DDAH/ADMA/NO pathway.

Research Products

• [Journal Article] Anti-hypertensive effects of shichimotsukokato in 5/6 nephrectomized Wistar rats mediated by DDAH-ADMA-NO pathway (2012)
  • Author(s): Fan Bai, Toshiaki Makino, Takahiko Ono, Hajime Mizukami
  • Journal Title: J.Nat.Med. Volume: (印刷中) Issue: 4 Pages: 583-590
  • DOI: 10.1007/s11418-011-0625-8
  • NAID: 10031088105
  • Year and Date: 2012-02-21
  • Peer Reviewed
• [Journal Article] 慢性腎臓病(CKD)における凝固系と凝固第Xa因子の役割(Review) (2012)
  • Author(s): 小野孝彦
  • Journal Title: YAKUGAKU ZASSHI Volume: 132 Pages: 449-453
• [Journal Article] Roles of coagulation pathway and factor Xa in the progression of diabetic nephropathy in db/db mice (2011)
  • Author(s): Ayaka Sumi, Natsuko Y Hanada, Fan Bai, Toshiaki Makino, Hajime Mizukami, Takahiko Ono
  • Journal Title: Biol. Pharm. Bull. Volume: 34(6) Pages: 824-830
  • NAID: 130000738056
• [Journal Article] Roles of coagulation pathway and factor Xa in the progression of diabetic nephropathy in db/db mice (2011)
  • Author(s): Sumi A, Makino T, Ono T, et al.
  • Journal Title: Biol.Phar.Bull. Volume: (印刷中)
  • NAID: 130000738056
  • Peer Reviewed
• [Journal Article] Basic study and clinical practice of Kampo medicines in chronic kidney disease(CKD): chronic glomerulonephritis and nephrosclerosis (2009)
  • Author(s): Takahiko Ono, Toshiaki Makino
  • Journal Title: J. Trad. Med. Volume: 26(5/6) Pages: 230-234
  • NAID: 10025956286
• [Journal Article] Basic study and clinical practice of Kampo medicines in chronic kidney disease(CKD) : chronic glomerulonephritis and nephrosclerosis (2009)
  • Author(s): Takahiko Ono, Toshiaki Makino
  • Journal Title: J Trad Med 26 Pages: 230-234
  • NAID: 10025956286
  • Peer Reviewed
• [Journal Article] Anti-hypertensive effects of shichimotsukokato in 5/6 nephrectomized Wistar rats mediated by DDAH-ADMA-NO pathway
  • Author(s): Fan Bai, Toshiaki Makino, Takahik o Ono, Hajime Mizukami
  • Journal Title: J. Nat. Med. Volume: (in press)
  • NAID: 10031088105
• [Presentation] Effects of shichimotsukokato on hypertensive CKD model (2011)
  • Author(s): 白帆、牧野利明、小野孝彦、水上元
  • Organizer: 第28回和漢医薬学会学術大会
  • Place of Presentation: 富山
  • Year and Date: 2011-08-28
• [Presentation] Protective Effects of Shichimotsukokato on Anti-Thy-1-Induced Irreversible Nephritis in Rats (2010)
  • Author(s): Takhiko Ono, et al
  • Organizer: 43nd Annual Meeting, Renal Week 2010, Am. Soc. Nephrol.
  • Place of Presentation: デンバー、アメリカコロラド州
  • Year and Date: 2010-11-20
• [Presentation] Protective Effects of Shichimotsukokato on Anti-Thy-1-Induced Irreversible Nephritis in Rats (2010)
  • Author(s): Takhiko Ono, et al.
  • Organizer: 43nd Annual Meeting, Renal Week 2010, Am.Soc.Nephrol.
  • Place of Presentation: デンバー市(アメリカコロラド州)
  • Year and Date: 2010-11-20
• [Presentation] ARBに七物降下湯の併用で尿蛋白の減少をみた慢性腎臓病の1例 (2010)
  • Author(s): 小野孝彦ほか
  • Organizer: 第40回日本東洋医学会東海支部学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-11-07
• [Presentation] ARBに七物降下湯の併用で尿蛋白の減少をみた慢性腎臓病の1例 (2010)
  • Author(s): 小野孝彦, 他
  • Organizer: 第40回日本東洋医学会東海支部学術総会
  • Place of Presentation: 名古屋大学鶴友会館(愛知県)
  • Year and Date: 2010-11-07
• [Presentation] 慢性腎臓病CKDと関連病態の漢方治療.～高血圧を伴ったCKDに対する漢方治療の基礎と臨床 (2010)
  • Author(s): 小野孝彦ほか
  • Organizer: 第61回日本東洋医学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-06-06
• [Presentation] シンポジウム 慢性腎臓病CKDと関連病態の漢方治療.高血圧を伴ったCKDに対する漢方治療の基礎と臨床 (2010)
  • Author(s): 小野孝彦, 他
  • Organizer: 第61回 日本東洋医学会学術総会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2010-06-06
• [Presentation] シンポジウム 慢性腎臓病(CKD)と漢方:慢性腎炎・腎硬化症への漢方方剤の運用と基礎的検討 (2009)
  • Author(s): 小野孝彦, 牧野利明
  • Organizer: 第26回和漢医薬学会
  • Place of Presentation: 千葉市
  • Year and Date: 2009-08-30
• [Book] 共著腎保護を意識した循環器薬の使い方BEAMシリーズNo.1.循環器の基本薬を使いこなす (2010)
  • Author(s): 小野孝彦, ほか
  • Total Pages: 131
  • Publisher: 文光堂
• [Book] 腎保護を意識した循環器薬の使い方.BEAMシリーズNo.1.循環器の基本薬を使いこなす (2010)
  • Author(s): 小野孝彦, 他 共著
  • Publisher: 文光堂