Analysis of behavior disorder and the deficient rescue of CIN85 knockout mouse that shows hyperactivity and rearing neglect to newborns
Project/Area Number |
21590251
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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Research Institution | Gunma University |
Principal Investigator |
SIMOKAWA Noriaki 群馬大学, 大学院・医学系研究科, 准教授 (90235680)
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Co-Investigator(Kenkyū-buntansha) |
KOIBUCHI Noriyuki 群馬大学, 大学院・医学系研究科, 教授 (80234681)
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Project Period (FY) |
2009 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | CIN85 / 多動性 / ドーパミン受容体 / エンドサイトーシス / ノックアウトマウス / 哺育行動 / ドーパミン / プロラクチン / 視床下部 |
Research Abstract |
Cbl-interacting protein of 85 kDa (CIN85) is an adaptor protein implicated in the regulation of receptor trafficking and cell division. CIN85 knockout (CIN85 KO) mice displayed a hyperactivity phenotype. In CIN85 KO, the recruitment of the endocytic machinery required for D2DR endocytosis is diminished. Our findings indicate an important role of CIN85 in the regulation of dopamine receptor functions and provide new insight into a molecular explanation for hyperactive behavior.
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Report
(4 results)
Research Products
(63 results)
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[Journal Article] 1,2,5,6,9,10-αHexabromocyclododecane (HBCD) impairs thyroid hormone-induced dendrite arborization of Purkinje cells and suppresses thyroid hormone receptor-mediated transcription.2011
Author(s)
Ibhazehiebo K, Iwasaki T, Okano-Uchida T, Shimokawa N, Ishizaki Y, Koibuchi N.
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Journal Title
Cerebellum
Volume: 10
Pages: 22-31
Related Report
Peer Reviewed
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[Journal Article] CIN85 regulates dopamine receptor endocytosis and governs behavior in mice2010
Author(s)
Shimokawa N, Haglund K, Holter SM, Grabbe C, Kirkin V, Koibuchi N, Schultz C, Rozman J, Hoeller D, Qiu CH, Londono MB, Ikezawa J, Jedlicka P, Stein B, Schwarzacher WS, Wolfer PD, Ehrhardt N, Heuchel R, Nezis I, Brech A, Schmidt MH, Fuchs H, Gailus-Durner V, Klingenspor M, Bogler O, Wurst W, Deller T, Harbe de Angelis M, Dikic I
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Journal Title
EMBO J
Volume: 29
Pages: 2421-2432
Related Report
Peer Reviewed
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[Journal Article] CIN85 regulates dopamine receptor endocytosis and governs behavior in mice.2010
Author(s)
Shimokawa N, Haglund K, Ater SM, Grabbe C, Kirkin V, Koibuchi N, Schultz C, Rozman J, Hoeller D, Qiu CH, London MB, Ikezawa J, Jedlicka P, Stein B, Schwarzacher WS, Wolfer PD, Ehrhardt N, Heuchel R, Nezis I, Brech A, Schmidt MH, Fuchs H, Gailus-Durner V, Klingenspor M, Bogler 0, Wurst W, Deller T, Harbede Angelis M, Dikic I
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Journal Title
EMBO Journal
Volume: 29
Pages: 2421-2432
Related Report
Peer Reviewed
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[Journal Article] Activation of aromatase expression by retinoic acid receptor-related orphan receptor (ROR) τ in breast cancer cells: identification of a novel for response element2009
Author(s)
Odawara H, Iwasaki T, Horiguchi J, Rokutanda N, Hirooka K, Miyazaki W, Koibuchi Y, Shimokawa N, Iino Y, Takeyoshi I, Koibuchi N
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Journal Title
J. Biol. Chem
Volume: 284
Pages: 17711-17719
Related Report
Peer Reviewed
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[Journal Article] Activation of aromatase expression by retinoic acid receptor-related orphan receptor(ROR)α in breast cancer cells : identification of a novel for response element.2009
Author(s)
Odawara H, Iwasaki T, Horiguchi J, Rokutanda N, Hirooka K, Miyazaki W, Koibuchi Y, Shimokawa N, Iino Y, Takeyoshi I, Koibuchi N.
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Journal Title
Journal of Biological Chemistry 284
Pages: 17711-17719
Related Report
Peer Reviewed
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[Presentation] Cerebellar dysfunction and behavioral disorder in congenital hypothyroid (rdw) rat2011
Author(s)
Yamaguchi S., Ohsawa A., Yousefi B., Morioka S., Masuda H., Ronny, Hayashi H., Takatsuru Y., Iwasaki T., Shimokawa N., Umezu M., Koibuchi N
Organizer
4^<th> International Symposium Society for Research on the Cerebellum
Place of Presentation
Tokyo, Japan
Year and Date
2011-09-18
Related Report
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