Regulations of oxytocin receptor expression and estrogen action

• Project/Area Number: 21590253
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Environmental physiology (including Physical medicine and Nutritional physiology)
• Research Institution: University of Fukui
• Principal Investigator: MURATA Takuya 福井大学, 医学部, 准教授 (70281186)
• Co-Investigator(Kenkyū-buntansha): NARITA Kazumi 福井大学, 医学部, 助教 (80270958) ; ICHIMARU Toru 福井大学, 医学部, 助教 (30452121)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: オキシトシン / オキシトシンレセプター / エストロジェン / エストロジェンレセプター / ラット

Research Abstract

The oxytocin receptor is regulated by estrogen secreted from the ovary. Using several types of estrogenic compound, the effects of estrogen on the oxytocin receptor were demonstarated to be mediated by several types of estrogen receptor, including classical estrogen receptorsαandβ, and the membrane-associated receptor. In addition, the brain site where estrogen shows an inhibitory effect on food intake was demonstrated in developing female rats.

Research Products

• [Journal Article] Estrogen increases c-Fos expression in the paraventricular nucleus along with its anorexic effect in developing rats (2011)
  • Author(s): Chi JH, Narita K, Ichimaru T, Murata T.
  • Journal Title: Journal of Reproduction and Development Volume: Vol.57、No.3 Pages: 365-372
  • NAID: 10029050554
  • URL: https://www.jstage.jst.go.jp/article/jrd/57/3/57_10-189E/_pdf
  • Peer Reviewed
• [Journal Article] Estrogen increases c-Fos expression in the paraventricular nucleus along with its anorexic effect in developing rats (2011)
  • Author(s): Chi JH, Narita K, Ichimaru T, Murata T
  • Journal Title: Journal of Reproduction and Development Pages: 365-372
  • NAID: 10029050554
  • Peer Reviewed
• [Presentation] ラット子宮オキシトシンおよびエストロゲンレセプターの調節 (2011)
  • Author(s): 村田拓也
  • Organizer: 中部生理学会
  • Place of Presentation: 福井県県民ホール(福井市)
  • Year and Date: 2011-11-01
• [Presentation] Regulation of oxytocin receptor by estrogen in rat uterus (2011)
  • Author(s): 村田拓也
  • Organizer: 国際内分泌学会
  • Place of Presentation: 京都国際会館(京都市)
  • Year and Date: 2011-03-28
• [Presentation] Regulation of oxytocin receptor by estrogen in rat uterus (2010)
  • Author(s): 村田拓也
  • Organizer: 国際内分泌学会
  • Place of Presentation: 京都国際会館 (京都市)
  • Year and Date: 2010-03-28