| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
Estrogen induces the increase of intracellular Ca^<2+> concentrations in addition to transcriptional activity via nuclear receptor, but the membrane receptor except for GPR30 remains unknown. We have produced RNAi collection for GPCR, and examined the Ca^<2+> response and cell impedance in response to estrogen in the presence of RNAi collection. The membrane receptor did not be identified under the experimental conditions due to the weak response of estrogen. The other assay system will be requested to elucidate the estrogen membrane receptor.
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