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High throughput screening for G protein-coupled receptor(s) activated in response to estrogen by RNAi collection

Research Project

Project/Area Number 21590256
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionYamaguchi University

Principal Investigator

MIZUKAMI Yoichi  山口大学, 総合科学実験センター, 教授 (80274158)

Co-Investigator(Kenkyū-buntansha) YOKOMIZO Takehiko  九州大学, 医学研究院, 教授 (60302840)
岡本 まり子  山口大学, 総合科学実験センター, 助教 (30415111)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords女性ホルモン / 細胞膜受容体 / G蛋白結合型受容体 / RNAi / スクリーニング / エストロゲン / エストエゲン / GPCR / シグナル伝達 / 受容体 / 生殖器
Research Abstract

Estrogen induces the increase of intracellular Ca^<2+> concentrations in addition to transcriptional activity via nuclear receptor, but the membrane receptor except for GPR30 remains unknown. We have produced RNAi collection for GPCR, and examined the Ca^<2+> response and cell impedance in response to estrogen in the presence of RNAi collection. The membrane receptor did not be identified under the experimental conditions due to the weak response of estrogen. The other assay system will be requested to elucidate the estrogen membrane receptor.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (65 results)

All 2012 2011 2010 2009 Other

All Journal Article (26 results) (of which Peer Reviewed: 23 results) Presentation (34 results) Book (2 results) Remarks (1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Optimizing high-resolution melting analysis for the detection of mutations of GPR30/ GPER-1 in breast cancer2012

    • Author(s)
      Aihara, M., Yamamoto, S., Nishioka, H., Hamano, K., Oka, M., and Mizukami, Y.
    • Journal Title

      Gene

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A high-affinity monoclonal antibody against the FLAG tag useful for G-protein coupled receptor study2012

    • Author(s)
      Sasaki, F., Okuno, T., Saeki, K., Min, L., Onohara, N., Kato, H., Shimizu, T. and Yokomizo, T.
    • Journal Title

      Anal. Biochem

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 細胞膜エストロゲン受容体GPER/ GPR30は,なぜ小胞体で見つかったのか2012

    • Author(s)
      水上洋一
    • Journal Title

      日本薬理学会誌

    • NAID

      10029604194

    • Related Report
      2011 Final Research Report
  • [Journal Article] 細胞膜エストロゲン受容体GPER/GPR30は,なぜ小胞体で見つかったのか!2012

    • Author(s)
      水上洋一
    • Journal Title

      日本薬理学会誌

      Volume: (印刷中)

    • NAID

      10029604194

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optimizing high-resolution melting analysis for the detection of mutations of GPR30/GPER-1 in breast cancer2012

    • Author(s)
      Aihara, M., Yamamoto, S., Nishioka, H., Hamano, K., Oka, M., Mizukami, Y.
    • Journal Title

      Gene

      Volume: (in press) Issue: 2 Pages: 95-105

    • DOI

      10.1016/j.gene.2012.04.029

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A high-affinity monoclonal antibody against the FLAG tag useful for G-protein coupled receptor study2012

    • Author(s)
      F.Sasaki
    • Journal Title

      Analytical Biochemistry

      Volume: (掲載決定) Issue: 2 Pages: 157-165

    • DOI

      10.1016/j.ab.2012.03.014

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gタンパク質共役型受容体と生理活性脂質2012

    • Author(s)
      横溝岳彦
    • Journal Title

      臨床検査

      Volume: 63 Pages: 117-124

    • Related Report
      2011 Annual Research Report
  • [Journal Article] IL-27 inhibits pathophysiological intraocular neovascularization due to laser burn2012

    • Author(s)
      Hasegawa E, Oshima Y, Takeda A, Saeki K, Yoshida H, Sonoda KH, Ishibashi T
    • Journal Title

      J.Leukoc.Biol.

      Volume: 91 Issue: 2 Pages: 267-273

    • DOI

      10.1189/jlb.1110603

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] International Union of Basic and Clinical Pharmacology. LXXXIV : Leukotriene Receptor Nomenclature, Distribution, and Pathophysiological Functions2011

    • Author(s)
      Back, M., Dahlen, S. E., Drazen, J. M., Evans, J. F., Serhan, C. N., Shimizu, T., Yokomizo, T. and Rovati, G. E.
    • Journal Title

      Pharmacol

      Volume: 63 Pages: 539-584

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Alterations in adhesion junction precede gap junction remodeling during the development of heart failure in cardiomyopathic hamster.2011

    • Author(s)
      Yoshida M, Ohkusa T, Nakashima T, Takanari H, Yano M, Takemura G, Honjo H, Kodama I, Mizukami Y, Matsuzaki. M.
    • Journal Title

      Cardiovasc

      Volume: 92(1) Pages: 95-105

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Operative injury accelerates tumor growth by inducing mobilization and recruitment of bone marrow-derived stem cells.2011

    • Author(s)
      Takemoto Y, Li TS, Kubo M, Ohshima M, Ueda K, Harada E, Enoki T, Okamoto M, Mizukami Y, Murata T, Hamano K.
    • Journal Title

      Surgery

      Volume: 149(6) Pages: 792-800

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Operative injury accelerates tumor growth by inducing mobilization and recruitment of bone marrow-derived stem cells2011

    • Author(s)
      Takemoto Y, Li TS, Kubo M, Ohshima H, Ueda K, Harada E, Enoki T, Okamoto M, Mizukami Y, Murata T, Hamano K
    • Journal Title

      Surgery

      Volume: Jun;149(6) Issue: 6 Pages: 792-800

    • DOI

      10.1016/j.surg.2011.02.005

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alterations in adhesion junction precede gap junction remodeling during the development of heart failure in cardiomyopathic hamster2011

    • Author(s)
      Yoshida M, Ohkusa T, Nakashima T, Takanari H, Yano M, Takemura G, Honjo H, Kodama I, Mizukami Y, Matsuzaki, M
    • Journal Title

      Cardiovasc.Res

      Volume: Oct 1;92(1) Issue: 1 Pages: 95-105

    • DOI

      10.1093/cvr/cvr182

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Leukotriene B_4 receptors : Novel roles in immunological regulations2011

    • Author(s)
      Yokomizo T
    • Journal Title

      Adv.Enzyme Regul.

      Volume: 51 Issue: 1 Pages: 59-64

    • DOI

      10.1016/j.advenzreg.2010.08.002

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] What is the natural ligand of GPR55?2011

    • Author(s)
      Okuno T, Yokomizo T
    • Journal Title

      J.Biochem.(Tokyo)

      Volume: 149 Issue: 5 Pages: 495-497

    • DOI

      10.1093/jb/mvr022

    • NAID

      10030584968

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proteomic Analysis of Proteins Expressing in Regions of Rat Brain by Combination of SDS-PAGE with Nano-Liquid Chromatography-Quadrupole Tandem Mass spectrometry2010

    • Author(s)
      Katagiri, T., Hatano, N., Aihara, M., Kawano, H., Okamoto, M., Xing, L., Izumi, T., Maekawa, T., Nakamura, S., Ishihara, T., Shirai, M., Mizukami, Y.
    • Journal Title

      Proteome Science

      Volume: 8(1): 41

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] In vivo functions of GPR30/ GPER-1, a membrane receptor for estrogen-From discovery to functions in vivo-2010

    • Author(s)
      Mizukami, Y.
    • Journal Title

      Endocrine J.

      Volume: 57(2) Pages: 101-107

    • NAID

      10029583542

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Proteomic Analysis of Proteins Expressing in Regions of Rat Brain by Combination of SDS-PAGE with Nano-Liquid Chromatography-Quadrupole Tandem Mass spectrometry2010

    • Author(s)
      Katagiri, T., et al
    • Journal Title

      Proteome Science

      Volume: 8(1):41(Epub ahead of print)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo functions of GPR30/GPER-1, a membrane receptor forestrogen-From discovery to functions in vivo-2010

    • Author(s)
      Mizukami, Y.
    • Journal Title

      Endocrine J.

      Volume: 57(2) Pages: 101-107

    • NAID

      10029583542

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo functions of GPR30/GPER-1, a membrane receptor for estrogen-From discovery to functions in vivo-2010

    • Author(s)
      Mizukami, Y.
    • Journal Title

      Endocrine J (In press)

    • NAID

      10029583542

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neurtrophil elastase inhibitor, ONO-5046, attenuates hippocampal neuronal damage after transient forebrain ischemia in rats2009

    • Author(s)
      Matayoshi, H., Hirata, T., Yamashita S., Ishida, K., Mizukami, Y., Gondo, T., Matsumoto, M., Sakabe, T.
    • Journal Title

      Brain Res

      Volume: 1259 Pages: 98-106

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Repeated preconditioning with hyperbaric oxygen induces neuroprotection against forebrain ischemia via suppression of p38 mitogen activated protein kinase2009

    • Author(s)
      Yamashita, S., Hirata, T., Mizukami, Y. Cui, Y. J., Fukuda, S., Ishida, K., Matsumoto, M., Sakabe, T.
    • Journal Title

      Brain Res.

      Volume: 1301 Pages: 171-179

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 性ステロイドホルモンとGPCR2009

    • Author(s)
      水上洋一
    • Journal Title

      実験医学

      Volume: 8 Pages: 2080-2086

    • Related Report
      2011 Final Research Report
  • [Journal Article] Neurtrophil elastase inhibitor, ONO-5046, attenuates hippocampal neuronal damage after transient forebrain ischemia in rats2009

    • Author(s)
      Matayoshi, H., et al
    • Journal Title

      Brain Res. 1259

      Pages: 98-106

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Repeated preconditioning with hyperbaric oxygen induces neuroprotection against forebrain ischemia via suppression of p38 mitogen activated protein kinase2009

    • Author(s)
      Yamashita, S., et al
    • Journal Title

      Brain Res. 1301

      Pages: 171-179

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 性ステロイドホルモンとGPCR2009

    • Author(s)
      水上洋一
    • Journal Title

      実験医学 8

      Pages: 2080-2086

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Generation of a novel anti-FLAG monoclonal antibody2012

    • Author(s)
      Yokomizo T.
    • Organizer
      The 7th Korea-Japan Conference on Cellular Signaling for Young Scientists
    • Place of Presentation
      Ulsan, Korea
    • Related Report
      2011 Final Research Report
  • [Presentation] Generation of a novel anti-FLAG monoclonal antibody2012

    • Author(s)
      Yokomizo, T
    • Organizer
      The 7th Korea-Japan Conference on Cellular Signaling for Young Scientists
    • Place of Presentation
      韓国(Ulsan)(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 生理活性脂質受容体の同定と生体内機能の解析・高親和性FLAG抗体の樹立と応用2011

    • Author(s)
      横溝岳彦
    • Organizer
      第2回九州エリア薬理・生理学若手研究会
    • Place of Presentation
      九州大学馬出病院地区コラボステーション1視聴覚室福岡(招待講演)
    • Year and Date
      2011-12-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] Crucial role of the leukotriene B4 receptor 2, BLT2 in epidermal wound healing.(Oralaward)2011

    • Author(s)
      Liu M., Saeki K., Yokomizo T.
    • Organizer
      The 10th Global COE International Symposium & 7th Young Investigators Forum
    • Place of Presentation
      Singapore Singapore
    • Year and Date
      2011-12-23
    • Related Report
      2011 Final Research Report
  • [Presentation] Two distinct leukotriene B4 receptors : BLT1 and BLT22011

    • Author(s)
      Yokomizo, T, Liu, M, Saeki, K, Okuno
    • Organizer
      The 10th JBS Biofrontier Symposium : New aspects of phospholipid biology and medicine
    • Place of Presentation
      ホテル・ルイガンス福岡(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Crucial role of the leukotriene B4 receptor BLT2 in epidermal wound healing2011

    • Author(s)
      Liu M., Saeki K., Abe Y., Yokomizo T.
    • Organizer
      Experimental Biology (Annual Meeting of American Society for Biochemistry and Molecular Biology)
    • Place of Presentation
      Washington DC (USA)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Roles of 12-HHT/LTB4 receptor, BLT2 in murine inflammatory colitis2011

    • Author(s)
      Okuno T., Iizuka Y., Saeki K., Yokomizo T.
    • Organizer
      Experimental Biology (Annual Meeting of American Society for Biochemistry and Molecular Biology)
    • Place of Presentation
      Washington DC (USA)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Leukotriene B4 augments and restores FcgRs-dependent phagocytosis in macrophages2011

    • Author(s)
      Saeki K., Okamoto F., Yamasaki S., Yokomizo T
    • Organizer
      Experimental Biology (Annual Meeting of American Society for Biochemistry and Molecular Biology)
    • Place of Presentation
      Washington DC (USA)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Generation of monoclonal antibodies specific for mouse leukotriene B4 receptor 1 and N-terminal FLAG sequence2011

    • Author(s)
      Sasaki F., Saeki K., Okuno T., Yokomizo T.
    • Organizer
      Experimental Biology (Annual Meeting of American Society for Biochemistry and Molecular Biology)
    • Place of Presentation
      Washington DC (USA)
    • Related Report
      2011 Annual Research Report
  • [Presentation] BLT1 as a potential marker of mouse dendritic cell subsets2011

    • Author(s)
      Koga T., Sasaki F., Saeki K., Okuno T., Yokomizo T.
    • Organizer
      The 10th JBS Biofrontier Symposium : New aspects of phospholipid biology and medicine
    • Place of Presentation
      ホテル・ルイガンス福岡
    • Related Report
      2011 Annual Research Report
  • [Presentation] Two distinct pathway for biosynthesis of 12-HHT, a ligand for BLT22011

    • Author(s)
      Matsunobu T., Okuno T., Yokomizo T.
    • Organizer
      The 10th JBS Biofrontier Symposium : New aspects of phospholipid biology and medicine
    • Place of Presentation
      ホテル・ルイガンス福岡
    • Related Report
      2011 Annual Research Report
  • [Presentation] 12-HHT is a natural ligand for BLT22011

    • Author(s)
      Okuno T., Yokomizo T.
    • Organizer
      The 10th JBS Biofrontier Symposium : New aspects of phospholipid biology and medicine
    • Place of Presentation
      ホテル・ルイガンス福岡
    • Related Report
      2011 Annual Research Report
  • [Presentation] Leukotriene B4 augments and restores FcgRs-dependent phagocytosis in macrophages2011

    • Author(s)
      Saeki K., Okamoto F., Yokomizo T
    • Organizer
      The 10th JBS Biofrontier Symposium : New aspects of phospholipid biology and medicine
    • Place of Presentation
      ホテル・ルイガンス福岡
    • Related Report
      2011 Annual Research Report
  • [Presentation] Expression of an LTB4 receptor BLT1 in M2 macrophages2011

    • Author(s)
      Sasaki F., Koga T., Saeki K., Okuno T., Yokomizo T.
    • Organizer
      The 10th JBS Biofrontier Symposium : New aspects of phospholipid biology and medicine
    • Place of Presentation
      ホテル・ルイガンス福岡
    • Related Report
      2011 Annual Research Report
  • [Presentation] ロイコトリエンB4第二受容体BLT2の新しいリガンド12-HHTの生合成機構の解明2011

    • Author(s)
      松延武彦, 奥野利明, 横溝岳彦
    • Organizer
      第53回日本脂質生化学会
    • Place of Presentation
      東京ガーデンパレス東京
    • Related Report
      2011 Annual Research Report
  • [Presentation] 二つのロイコトリエンB4受容体(BLT1,BLT2)のシグナルと病態生理機能2011

    • Author(s)
      佐伯和子, 劉〓, 岡元冬樹, 奥野利明, 横溝岳彦
    • Organizer
      第84回日本生化学会大会シンポジウム
    • Place of Presentation
      国立京都国際会館京都
    • Related Report
      2011 Annual Research Report
  • [Presentation] Crucial role of the leukotriene B4 receptor BLT2 in epidermal wound healing2011

    • Author(s)
      Liu M., 佐伯和子, 奥野利明, 横溝岳彦
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館京都
    • Related Report
      2011 Annual Research Report
  • [Presentation] GPCRの免疫沈降に有用な新規抗FLAG抗体の樹立と本抗体を用いた新規GPCR結合タンパク質の探索2011

    • Author(s)
      佐々木文之, 奥野利明, 佐伯和子, 横溝岳彦
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館京都
    • Related Report
      2011 Annual Research Report
  • [Presentation] 結晶化のためのロイコトリエンB4受容体(BLT1)の熱安定化と抗BLT1モノクローナル抗体の作製2011

    • Author(s)
      堀哲哉, 菅原光明, 中材元直, 横溝岳彦, 清水孝雄, 宮野雅司
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館京都
    • Related Report
      2011 Annual Research Report
  • [Presentation] Helix 8 of the leukotriene B4 receptor type 1 inhibits ligand-induced internalization2011

    • Author(s)
      荒武良総, 奥野利明, 横溝岳彦
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館京都
    • Related Report
      2011 Annual Research Report
  • [Presentation] ゼブラフィッシュのロイコトリエンB4/12-HHT受容体の同定2011

    • Author(s)
      奥野利明, 石谷太, 横溝岳彦
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館京都
    • Related Report
      2011 Annual Research Report
  • [Presentation] Two distinct pathways for biosynthesis of 12-HHT, a ligand for BLT22011

    • Author(s)
      松延武彦, 奥野利明, 横溝岳彦
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館京都
    • Related Report
      2011 Annual Research Report
  • [Presentation] 新規細胞膜エストロゲン受容体GPR30遺伝子の未知変異検出法の確立2010

    • Author(s)
      相原正宗, 山本滋, 西岡弘子, 岡本まり子, 岡正朗, 水上洋一
    • Organizer
      日本生化学会
    • Place of Presentation
      神戸市神戸市民会館
    • Year and Date
      2010-12-07
    • Related Report
      2011 Final Research Report
  • [Presentation] 新規細胞膜エストロゲン受容体GPR30遺伝子の未知変異検出法の確立2010

    • Author(s)
      相原正宗
    • Organizer
      日本生化学会
    • Place of Presentation
      神戸, 神戸市民会館
    • Year and Date
      2010-12-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] 乳がん組織における細胞膜女性ホルモン受容体GPR30の遺伝子変異の検出2010

    • Author(s)
      相原正宗, 山本滋, 西岡弘子, 岡本まり子, 岡正朗, 水上洋一
    • Organizer
      第111回山口大学医学会学術講演会
    • Place of Presentation
      宇部市山口大学霜仁会館
    • Year and Date
      2010-07-18
    • Related Report
      2011 Final Research Report
  • [Presentation] 乳がん組織における細胞膜女性ホルモン受容体GPR30の速未知変異遺伝子変異の検出法の確立と疾患への応用2010

    • Author(s)
      相原正宗
    • Organizer
      第114回山口大学医学会学術講演会
    • Place of Presentation
      山口, 山口大学医学部霜仁会館
    • Year and Date
      2010-07-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] 細胞膜女性ホルモン受容体GPR30の高速未知変異遺伝子検出法の確立と疾患への応用2010

    • Author(s)
      相原正宗, 山本滋, 西岡弘子, 岡本まり子, 岡正朗, 水上洋一
    • Organizer
      日本生化学会中四国地方会
    • Place of Presentation
      山口市山口大学大学会館
    • Year and Date
      2010-05-15
    • Related Report
      2011 Final Research Report
  • [Presentation] TNFαシグナル伝達経路における新規細胞膜受容体GPR30の関与について2010

    • Author(s)
      岡本まり子, 相原正宗, 水上洋一
    • Organizer
      日本生化学会中四国地方会
    • Place of Presentation
      山口市山口大学大学会館
    • Year and Date
      2010-05-15
    • Related Report
      2011 Final Research Report
  • [Presentation] 細胞膜女性ホルモン受容体GPR30の高速未知変異遺伝子検出法の確立と疾患への応用2010

    • Author(s)
      相原正宗
    • Organizer
      日本生化学会中四国地方会
    • Place of Presentation
      山口,山口大学会館
    • Year and Date
      2010-05-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] TNFαシグナル伝達経路における新規細胞膜受容体GPR30の関与について2010

    • Author(s)
      岡本まり子
    • Organizer
      日本生化学会中四国地方会
    • Place of Presentation
      山口,山口大学会館
    • Year and Date
      2010-05-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Impact of a 3-linked galactose-containing oligosaccharides of a recombinant mouse/ human chimeric IgG mutant on its Fc effector functions2010

    • Author(s)
      Yusuke Mimura, Ronan Kelly, Yoichi Mizukami, Margaret Goodall, Roy Jefferis, Pauline M Rudd
    • Organizer
      14^<th> International Congress of Immunology
    • Place of Presentation
      Kobe, Japan Portpia Hall
    • Related Report
      2011 Final Research Report
  • [Presentation] Arrest of spermatogenesis at round spermatids in PLCZ1-deficient mice.2010

    • Author(s)
      Masahiko Ito, Kentaro Nagaoka, Keiji Kuroda, Natsuko Kawano, Keiichi, Yoshida, Yuichirou Harada, Tomohide Shikano, Mami Miyado, Shoji Oda, Kiyotaka Toshimori, Youichi Mizukami, Tomoaki Murata, Akihiro Umezawa, Shunichi Miyazaki, Kenji Miyado.
    • Organizer
      11th International Symposium on Spermatology
    • Place of Presentation
      Okinawa, Japan conbention center
    • Related Report
      2011 Final Research Report
  • [Presentation] Impact of α1,3-linked galactose-containing oligosaccharides of a recombinant mouse/human chimeric IgG mutant on its Fc effector functions2010

    • Author(s)
      Yusuke Mimura
    • Organizer
      14^<th> International Congress of Immunology
    • Place of Presentation
      Kobe, Japan, Kobe Portpia Hall
    • Related Report
      2010 Annual Research Report
  • [Presentation] Arrest of spermatogenesis at round spermatids in PLCZ1-deficient mice.2010

    • Author(s)
      Masahiko Ito
    • Organizer
      11th International Symposium on Spermatology.
    • Place of Presentation
      Okinawa, Japan, Okinawa convention center
    • Related Report
      2010 Annual Research Report
  • [Book] イラストレイテッドハーパー、生化学原書2011

    • Author(s)
      横溝岳彦
    • Publisher
      丸善
    • Related Report
      2011 Final Research Report
  • [Book] 生化学実践問題基礎と臨床をつなぐ420題2011

    • Author(s)
      横溝岳彦
    • Total Pages
      214
    • Publisher
      南江堂
    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://gene.yamaguchi-u.ac.jp/

    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] 新規虚血マーカー及びこれを用いた虚血状態の検出方法2011

    • Inventor(s)
      水上洋一
    • Industrial Property Rights Holder
      山口大学
    • Patent Publication Number
      2011-257419
    • Filing Date
      2011-08-03
    • Acquisition Date
      2011-12-22
    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] エストロゲン疾患の判別方法2010

    • Inventor(s)
      水上洋一
    • Industrial Property Rights Holder
      山口大学
    • Patent Publication Number
      2012-034633
    • Filing Date
      2010-08-06
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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