Development of novel strategy for the treatment of inflammatory diseases with natural products such as herbal ingredients
| Project/Area Number |
21590278
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Nagoya University |
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Principal Investigator |
ISHIGURO Kazuhiro 名古屋大学, 大学院・医学系研究科, 講座准教授 (60432275)
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| Co-Investigator(Kenkyū-buntansha) |
ANDO Takafumi 名古屋大学, 大学院・医学系研究科, 准教授 (80378041)
GOTO Hidemi 名古屋大学, 大学院・医学系研究科, 教授 (10215501)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 炎症 / 腸炎 / 天然化合物 / 生薬 / マクロファージ / T細胞 / lipopolysaccharide / サイトカイン |
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| Research Abstract |
The action and therapeutic benefit of Dehydrocorydaline were demonstrated.
Atractylodin was found to inhibit IL-17production in activated T cells.
The molecular mechanism of acetate action on Tcell activation was elucidated.
The novel colitis model for fluorescence observation of hapten-protein was developed.
The novel agent for fluorescence observation of colitis was developed.
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Report
(4 results)
Research Products
(24 results)
