Studies on molecular basis for regulation of beta-oxidation system
| Project/Area Number |
21590314
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
HOMMA Yoshimi 福島県立医科大学, 医学部, 教授 (60192324)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | リン酸化 / シグナル / ミトコンドリア / デヒドロゲナーゼ / 脂肪酸 / 過酸化脂質 |
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| Research Abstract |
Phosphorylation level of VLCAD1 decreased in mitochondria of lung fibroblasts established from patients with idiopathic pulmonary lung fibrosis. PKA phosphorylated VLCAD1 at Ser-586, and its phosphorylation-defective mutant enhanced production of radical oxygen species. These suggest that beta oxidation system is regulated by intra-mitochondrial signaling system including PKA.
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Report
(4 results)
Research Products
(20 results)
