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Studies on molecular basis for regulation of beta-oxidation system

Research Project

Project/Area Number 21590314
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General medical chemistry
Research InstitutionFukushima Medical University

Principal Investigator

HOMMA Yoshimi  福島県立医科大学, 医学部, 教授 (60192324)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsリン酸化 / シグナル / ミトコンドリア / デヒドロゲナーゼ / 脂肪酸 / 過酸化脂質
Research Abstract

Phosphorylation level of VLCAD1 decreased in mitochondria of lung fibroblasts established from patients with idiopathic pulmonary lung fibrosis. PKA phosphorylated VLCAD1 at Ser-586, and its phosphorylation-defective mutant enhanced production of radical oxygen species. These suggest that beta oxidation system is regulated by intra-mitochondrial signaling system including PKA.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (20 results)

All 2012 2011 2010 2009 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (13 results) Remarks (2 results)

  • [Journal Article] Coronary vasospasm induced in transgenic mouse with the increased phospholipase C-δ1 activity2012

    • Author(s)
      Shibutani S, et al
    • Journal Title

      Circulation

      Volume: 125 Pages: 1027-36

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CpG methylation prevents YY1-mediated transcriptional activation of the vimentin promoter2011

    • Author(s)
      Sekimata M, et al
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 414 Pages: 767-72

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dysregulation of very long chain acyl-CoA dehydrogenase coupled with lipid peroxidation2010

    • Author(s)
      Kabuyama Y, Suzuki T, Nakazawa N, Yamaki J, Homma MK, Homma Y
    • Journal Title

      Am J Physiol Cell Physiol

      Volume: 298巻

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] p122 protein enhances intracellular calcium increase to acetylcholine. Its possible role in the pathogenesis of coronary spastic angina2010

    • Author(s)
      Murakami R, Osanai T, Tomita H, Sasaki S, Maruyama A, Itoh K, Homma Y, Okumura K
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 30巻 Pages: 1968-1975

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dysregulation of very long chain acyl-CoA dehydrogenase coupled with lipid peroxydation.2009

    • Author(s)
      Kabuyama Y, et al.
    • Journal Title

      Am J Physiol Cell Physiol 298

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Identification of autophosphorylation residues in CK2 by mass spectrometric analysis2011

    • Author(s)
      本間美和子, ほか
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] ミトコンドリアc-Srcキナーゼ活性を制御する新規相互作用タンパク質の同定と機能解析2011

    • Author(s)
      小椋正人, 八巻淳子, 本間美和子, 本間好
    • Organizer
      84回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-24
    • Related Report
      2011 Final Research Report
  • [Presentation] ミトコンドリアc-Srcキナーゼ活性を制御する新規相互作用タンパク質の同定と機能解析2011

    • Author(s)
      小椋正人, ほか
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] Src regulates mitochondria function and ROS generation through direct phosphorylation of respiration components2011

    • Author(s)
      Homma Y, Ogura M, Homma MK
    • Organizer
      Charles Heidelberger International Symposium on Cancer Research
    • Place of Presentation
      中国西安
    • Year and Date
      2011-06-06
    • Related Report
      2011 Final Research Report
  • [Presentation] Src regulates mitochondria function and ROS generation through direct phosphorylation of respiratory components2011

    • Author(s)
      Homma Y, et al
    • Organizer
      The 17^<th> International Charles Heidelberger Symposium on Cancer Research
    • Place of Presentation
      Xian, China
    • Year and Date
      2011-06-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] Reguratory mechanism of oxidative phosphorylation by mitochondrial c-Src2011

    • Author(s)
      Ogura M, Yamaki J, Homma MK, Homma Y
    • Organizer
      Keystone Symposia on Molecular and Cellular Biology
    • Place of Presentation
      米国キーストーン
    • Year and Date
      2011-01-26
    • Related Report
      2011 Final Research Report
  • [Presentation] Regulation of oxidative phosphorylation by mitochondrial c-Src2010

    • Author(s)
      小椋正人, 八巻淳子, 本間美和子, 本間好
    • Organizer
      83回日本生化学会大会
    • Place of Presentation
      神戸市
    • Year and Date
      2010-12-10
    • Related Report
      2011 Final Research Report
  • [Presentation] Regulation of oxidative phosphorylation of mitochondrial c-Src2010

    • Author(s)
      小椋正人, ら
    • Organizer
      第83回日本生化学会大会
    • Place of Presentation
      神戸市
    • Year and Date
      2010-12-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Autophosphorylation of CK2 N-terminal region controls activation and nuclear localization during the progression of cell cycle2010

    • Author(s)
      本間美和子, ら
    • Organizer
      第83回日本生化学会大会
    • Place of Presentation
      神戸市
    • Year and Date
      2010-12-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] ROS production in lung fibrosis myofibroblasts2010

    • Author(s)
      Homma Y
    • Organizer
      Charles Heidelberger International Symposium on Cancer Research
    • Place of Presentation
      タイ国ピサヌローク
    • Year and Date
      2010-01-18
    • Related Report
      2011 Final Research Report
  • [Presentation] ROS production in lung fibrosis myofibroblasts.2010

    • Author(s)
      Homma, Y
    • Organizer
      15^<th> Charles Heidelberger International Symposium on Cancer Research
    • Place of Presentation
      タイ、ピサヌローク市
    • Year and Date
      2010-01-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] 肺線維芽細胞のプロテオミクス解析2009

    • Author(s)
      鈴木俊幸, 蕪山由己人, 八巻淳子, 本間美和子, 本間好
    • Organizer
      82回日本生化学会大会
    • Place of Presentation
      神戸市
    • Year and Date
      2009-12-22
    • Related Report
      2011 Final Research Report
  • [Presentation] 肺線維芽細胞のプロテオミクス解析2009

    • Author(s)
      鈴木俊幸, ら
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸市
    • Year and Date
      2009-10-22
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.fmu.ac.jp/home/biomol/html/index.html

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.fmu.ac.jp/home/biomol/HTML/index.html

    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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