The function of mitochondrial CYP1A1 in the lipid metabolism.

Research Project

Project/Area Number	21590319
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	General medical chemistry
Research Institution	Nihon University
Principal Investigator	UNO Shigeyuki 日本大学, 医学部, 講師 (90307851)
Project Period (FY)	2009 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000) Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	生体分子医学 / チトクロームP450 / ミトコンドリア / 生体異物代謝 / 脂質代謝
Research Abstract	To understand the physiological functions of polycyclic aromatic hydrocarbons(PHAs) induced microsomal versus mitochondrial CYP1A1, it is the microsomal rather than mitochondrial CYP1A1 enzyme that protects against oral BaP toxicity. Because of metabolic delay of PHAs causes abnormal expression of transporter genes, PHAs is induced abnormal lipid metabolism. Our data support the likelihood that it is the microsomal rather than mitochondrial CYP1A1 enzyme that protects against PHAs induced mitochondrial dysfunction.

Report

(4 results)