Analysis of the function of ciliopathy-related genes in the regulation of ciliary movement
| Project/Area Number |
21590358
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human genetics
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| Research Institution | Yamaguchi University |
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Principal Investigator |
HORI Manabu 山口大学, 大学院・理工学研究科, 准教授 (00253138)
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| Co-Investigator(Kenkyū-buntansha) |
NOGUCHI Munenori 富山大学, 大学院・理工学研究科, 教授 (30019004)
TOMINAGA Takashi 徳島文理大学, 薬学部, 准教授 (20344046)
ISHIDA Masaki 奈良教育大学, 教育学部, 教授 (80291053)
NAITOH Yutaka 徳島文理大学, 薬学部, 客員教授 (40091912)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 繊毛病 / 繊毛運動 / ciliopathy / 繊毛打 / ゾウリムシ / ダイニン |
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| Research Abstract |
In paramecia, we analyzed ciliary motility and sensory functions of cilia, which are gene-silenced orthologous genes related to human ciliopathy by RNAi. The knockdown of the gene encoding the axonemal proteins causes structural defects and unstable ciliary movement. Alternatively, the knockdown of the gene which does not encoded the axonemal protein affects cellular function, but not ciliary movement.
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Report
(4 results)
Research Products
(36 results)
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[Journal Article] Bug22p, a Conserved Centrosomal/ Ciliary Protein Also Present in Higher Plants, Is Required for an Effective Ciliary Stroke in Paramecium2010
Author(s)
Laligne C, Klotz C, de Loubresse NG, Lemullois M, Hori M. Laurent FX, Papon JF, Louis B, Cohen J, Koll F
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Journal Title
Eukaryt Cell
Volume: vol.9
Pages: 645-655
Related Report
Peer Reviewed
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