Epigenetic regulation of gene expression in AFP-producing gastric adenocarcinoma

• Project/Area Number: 21590395
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human pathology
• Research Institution: Chiba University
• Principal Investigator: KISHIMOTO Takashi 千葉大学, 大学院・医学研究院, 准教授 (90323401)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2011: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
• Keywords: AFP産生胃癌 / エピジェネティック / GATA-4 / ヒストン脱アセチル化阻害 / DNAメチル化 / エピジェネティックス

Research Abstract

AFP-producing adenocarcinoma is a highly malignant variant of the gastric cancer. GATA-4 is a gene that is involved in both gastrointestinal and hepatic differentiation. GATA-4 expression was restricted by DNA methylation in common-type gastric adenocarcinomas, whereas, we found that it was restricted by histone deacetylation in AFP-producing adenocarcinomas.

Research Products

• [Journal Article] Epigenetic regulation of GATA4 expression by histone modification in AFP-producing gastric adenocarcinoma (2012)
  • Author(s): Yamamura N, Kishimoto T
  • Journal Title: Exp Mol Pathol
  • Peer Reviewed
• [Journal Article] Clear cell adenocarcinoma with enteroblastic differentiation of the ascending colon (2011)
  • Author(s): Furuya Y, Wakahara T, Akimoto H, Kishimoto T, Hiroshima K, Yanagie H, Yasuhara H
  • Journal Title: J Clin Oncol Volume: 29 Pages: 647-9
  • Peer Reviewed
• [Journal Article] Primary hepatoid adenocarcinoma of the uterine corpus : A case report with immunohistochemical study for expression of liver-enriched nuclear factors (2011)
  • Author(s): Ishibashi K, Kishimoto T, Yonemori Y, Hirashiki K, Hiroshima K, Nakatani Y
  • Journal Title: Pathol Res Pract Volume: 207 Pages: 332-6
  • Peer Reviewed
• [Journal Article] Hepatocyte growth factor inhibits anoikis of pancreatic carcinoma cells through phosphatidylinositol 3-kinase pathway (2011)
  • Author(s): Watanabe S, Kishimoto T, Yokosuka O
  • Journal Title: Pancreas Volume: 40 Pages: 608-14
  • Peer Reviewed
• [Journal Article] Early-stage mucinous sweat gland adenocarcinoma of eyelid (2011)
  • Author(s): Nizawa T, Oshitari T, Kimoto R, Kajita F, Yotsukura J, Asanagi K, Baba T, Takahashi Y, Oide T, Kiyokawa T, Kishimoto T, Yamamoto S
  • Journal Title: Clin Ophthalmol Volume: 5 Pages: 687-9
  • Peer Reviewed
• [Journal Article] 非典型的な画像所見を呈した非機能性膵神経内分泌腫瘍の1例 (2011)
  • Author(s): 細川勇, 竹内男, 大塚将之, 吉富秀幸, 岸本充, 宮崎勝
  • Journal Title: 日本臨床外科学会雑誌 Volume: 72 Pages: 1008-14
  • NAID: 10029098786
  • Peer Reviewed
• [Journal Article] Epigenetic regulation of GATA4 expression by histone modification in AFP-producing gastric adenocarcinoma (2011)
  • Author(s): Yamamura N, Kishimoto T
  • Journal Title: Experimental and Molecular Pathology Volume: (Epub ahead of print) Issue: 1 Pages: 35-39
  • DOI: 10.1016/j.yexmp.2012.03.012
  • Peer Reviewed
• [Journal Article] Clear cell adenocarcinoma with enteroblastic differentiation of the ascending colon (2011)
  • Author(s): Furuya Y, Wakahara T, Akimoto H, Kishimoto T, Hiroshima K, Yanagie H, Yasuhara H
  • Journal Title: Journal of Clinical Oncology Volume: 29 Pages: 647-649
  • Peer Reviewed
• [Journal Article] Primary hepatoid adenocarcinoma of the uterine corpus : A case report with immunohistochemical study for expression of liverenriched nuclear factors (2011)
  • Author(s): Ishibashi K, Kishimoto T, Yonemori Y, Hirashiki K, Hiroshima K, Nakatani Y
  • Journal Title: Pathology Research and Practice Volume: 207 Issue: 5 Pages: 332-336
  • DOI: 10.1016/j.prp.2011.02.010
  • Peer Reviewed
• [Journal Article] Relationship between chronic sclerosing dacryoadenitis with high level of IgG4 and Castleman disease (2010)
  • Author(s): Oshitari T, Yotsukura J, Asahagi K, Baba T, Kishimoto T, Yamamoto S
  • Journal Title: Clin Ophthalmol Volume: 5 Pages: 23-5
  • Peer Reviewed
• [Journal Article] Case of primary diffuse large B-cell lymphoma of lacrimal sac in a Japanese patient (2010)
  • Author(s): Kajita F, Oshitari T, Yotsukura J, Asanagi K, Baba T, Kishimoto T, Yamamoto S
  • Journal Title: Clin Ophthalmol Volume: 4 Pages: 1351-4
  • Peer Reviewed
• [Journal Article] (2010)
  • Author(s): Shida T, Kishimoto T, Furuya M, Nikaido T, Koda K, Takano S, Kimura F, Shimizu H, Yoshidome H, Ohtsuka M, Tanizawa T, Nakatani Y, Miyazaki M
  • Journal Title: Cancer Chemother Pharmacol Volume: 65 Pages: 889-93
  • Peer Reviewed
• [Journal Article] Recent advances in visualization and imaging in HBP science : Magnetic resonance imaging of hepatocellular carcinoma : a pictorial review of novel insights into pathophysiological features revealed by magnetic resonance imaging (2010)
  • Author(s): Shimofusa R, Ueda T, Kishimoto T, Nakajima M, Yoshikawa M, Kondo F, Ito H
  • Journal Title: Journal of Hepato-Biliary-Pancreatic Sciences Volume: 17 Pages: 583-9
  • Peer Reviewed
• [Presentation] Hepatocyte growth factorによる膵癌細胞のanoikis抑制 (2011)
  • Author(s): 岸本充, 渡辺聡, 富居一範, 清川貴子, 横須賀収
  • Organizer: 第100回日本病理学会
  • Place of Presentation: 横浜
  • Year and Date: 2011-04-30
• [Presentation] Hepatocyte growth factorによる膵癌細胞のanoikis抑制 (2011)
  • Author(s): 岸本充, 渡辺聡, 富居一範, 清川貴子, 横須賀収
  • Organizer: 日本病理学会
  • Place of Presentation: 横浜
  • Year and Date: 2011-04-30
• [Presentation] 脱分化を伴う子宮内膜間質肉腫(ESS)の一例 (2011)
  • Author(s): 岩本雅美, 清川貴子, 大出貴士, 米盛葉子, 岸本充, 中谷行雄
  • Organizer: 第100回日本病理学会会誌
  • Place of Presentation: 横浜
  • Year and Date: 2011-04-29
• [Presentation] 両側肺転移巣から発見された膵solid pseudopapillary tumorの1症例 (2011)
  • Author(s): 米盛葉子, 坂入祐一, 岸本充, 吉野一郎, 大塚将之, 宮崎勝, 中谷行雄
  • Organizer: 第100回日本病理学会会誌
  • Place of Presentation: 横浜
  • Year and Date: 2011-04-28
• [Presentation] 印環細胞癌への分化を伴ったALK陽性endobronchial polypoid adenocarcinomaの1例 (2010)
  • Author(s): 大出貴士, 岸本充, 廣島健三, 溝渕輝明, 鈴木実, 吉野一郎, 中谷行雄
  • Organizer: 第99回日本病理学会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-27
• [Book] 胃と腸 (2010)
  • Author(s): 岸本充
  • Publisher: 医学書院
• [Book] 病理と臨床 (2010)
  • Author(s): 岸本充
  • Publisher: 文光堂
• [Book] 消化管症候群(上) (2009)
  • Author(s): 岸本充
  • Publisher: 日本臨床社