Epigenetic regulation of gene expression in AFP-producing gastric adenocarcinoma
| Project/Area Number |
21590395
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Chiba University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | AFP産生胃癌 / エピジェネティック / GATA-4 / ヒストン脱アセチル化阻害 / DNAメチル化 / エピジェネティックス |
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| Research Abstract |
AFP-producing adenocarcinoma is a highly malignant variant of the gastric cancer. GATA-4 is a gene that is involved in both gastrointestinal and hepatic differentiation. GATA-4 expression was restricted by DNA methylation in common-type gastric adenocarcinomas, whereas, we found that it was restricted by histone deacetylation in AFP-producing adenocarcinomas.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Early-stage mucinous sweat gland adenocarcinoma of eyelid2011
Author(s)
Nizawa T, Oshitari T, Kimoto R, Kajita F, Yotsukura J, Asanagi K, Baba T, Takahashi Y, Oide T, Kiyokawa T, Kishimoto T, Yamamoto S
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Journal Title
Clin Ophthalmol
Volume: 5
Pages: 687-9
Related Report
Peer Reviewed
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[Journal Article]2010
Author(s)
Shida T, Kishimoto T, Furuya M, Nikaido T, Koda K, Takano S, Kimura F, Shimizu H, Yoshidome H, Ohtsuka M, Tanizawa T, Nakatani Y, Miyazaki M
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Journal Title
Cancer Chemother Pharmacol
Volume: 65
Pages: 889-93
Related Report
Peer Reviewed
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