Phosphoprotein array analyses for determination of signaling pathways activated by p63 in squamous cell carcinomas
| Project/Area Number |
21590434
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
KATOH Iyoko 山梨大学, 医学工学総合研究部, 准教授 (20333297)
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| Co-Investigator(Renkei-kenkyūsha) |
KURATA Shunichi 東京医科歯科大学, 難治疾患研究所, 准教授 (60140901)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 腫瘍 / p63 / PP2A / TCF-4 / Wnt / 癌 / シゲナル伝達 / 発現制御 / 遺伝子 / マイクロアレイ / シグナル伝達 / プロテオーム |
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| Research Abstract |
To explore p63-controlled cellular signaling pathways, we performed p63 RNA interference, phosphoprotein array analyses and gene expression profiling. Results suggest that the.ΔNp63αisoform interacts with protein phosphatase 2A(PP2A),β-catenin and TCF-4 to activate Wnt signal target gene expression.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Activation of the long terminal repeat of human endogenous retrovirus K by melanoma-specific transcription factor MITF-M2011
Author(s)
Katoh I, Mirova A, Kurata S, Murakami Y, Horikawa K, Nakakuki N, Sakai T, Hashimoto K, Maruyama A, Yonaga T, Fukunishi N, Moriishi K, Hirai H.
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Journal Title
Neoplasia
Volume: 13
Issue: 11
Pages: 1081-1092
DOI
Related Report
Peer Reviewed
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