Resistance of cancer stem cells to p53-induced cell death and its mechanism
| Project/Area Number |
21590438
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Doshisha Women's College of Liberal Arts |
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Principal Investigator |
TAKAHASHI Rei 同志社女子大学, 薬学部, 教授 (60144565)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 遺伝子 / バイオテクノロジー / 病理学 / 癌 / 細胞 / 組織 / 細胞・組織 |
|---|
| Research Abstract |
One of the therapeutic measures against cancer is to cause apoptotic cell death introduced by inducing p53 overexpression. In this study, we constructed a special breast cancer cell, by which apoptosis-resistant cells are analyzed. These apoptosis-resistant cancer cells were found to express. The ALDH1 gene that is considered as a marker of the breast cancer stem cell. Development of new drug can be promoted through the detail analyzes of the cancer stem cell population.
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Report
(4 results)
Research Products
(44 results)
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[Journal Article] A novel animal model of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in humanized mice2011
Author(s)
Sato K, Misawa N, Nie C, Satou Y, Iwakiri D, Matsuoka M, Takahashi R, Kuzushima K, Ito M, Takada K, Koyanagi Y
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Journal Title
Blood
Volume: 117
Issue: 21
Pages: 5663-5673
DOI
Related Report
Peer Reviewed
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