Studies on the mechanism to gain monocyte chemotactic capacity of ribosomal protein S19 and its role in coagulum resorption.
Project/Area Number |
21590441
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Experimental pathology
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Research Institution | Kumamoto University |
Principal Investigator |
YAMAMOTO Tetsuro 熊本大学, 大学院・生命科学研究部, 教授 (60112405)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | リボソームタンパク質S19 / プロトロンビン / 血液凝固反応 / 凝固XIII因子 / 血小板 / 線溶 / Glaドメイン / 血漿タンパク質 / ワーファリン / リボソームタンパク質 / 単球 / 白血球走化因子 / C5aレセプター / 凝血塊吸収 / S19リボソームタンパク質 / 単球走化因子 / 血液凝固XIII因子 / 細胞性線溶 / 血栓症 |
Research Abstract |
In the present research, we have revealed that ribosomal protein S19(RP S19) present in normal blood plasma is covalently dimerized by activated factor XIII on the activated platelet surface and gains monocyte chemotactic capacity during blood coagulation process, that the RP S19 dimer recruits monocytes to the coagulum resulting in cellular fibrinolytic absorption of the coagulum, and that monocytotic state of peripheral blood enhance the coagulum resorption process.
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] Ribosomal protein S19 is present in plasma as a complex with prothrombin2011
Author(s)
Nishiura, H., Tanase, S., Tsujita, K., Sugiyama, S., Ogawa, ・H., Nakagaki, T., Semba, U., and Yamamoto, T.
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Journal Title
Eur. J. Haematol.
Volume: 86
Issue: 5
Pages: 436-441
DOI
Related Report
Peer Reviewed
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[Journal Article] Role of ribosomal protein S19-like plasma protein in blood coagulum resorption2010
Author(s)
Ota, Y., Chen, J., Shin, M., Nishiura, H., Tokita, K., Shinohara, M., Yamamoto, T.
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Journal Title
Exp. Mol. Pathol.
Volume: 90
Pages: 19-28
Related Report
Peer Reviewed
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[Journal Article] Base of molecular mimicry between human ribosomal protein S19 dimer and human C5a anaphylatoxin2010
Author(s)
Nishiura, H., Chen, J., Ota, Y., Semba, U., Higuchi, H., Nakashima, T., Yamamoto, T.
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Journal Title
Int. Immunopharmacol.
Volume: 10(12)
Pages: 1541-1547
NAID
Related Report
Peer Reviewed
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[Journal Article] Inter-conversion between pure chemotactic ligands and chemoattractant/secretagogue ligands of neutrophil C5a receptor by a single amino acid substitution2010
Author(s)
Jia, N., Semba, U., Nishiura, H., Kuniyasu, A., Nsiama, T. K., Nishino, N., and Yamamoto, T.
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Journal Title
J. Leukocyt. Biol.
Volume: 87
Pages: 965-975
Related Report
Peer Reviewed
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[Journal Article] A Plasma Protein Indistinguishable from Ribosomal Protein S19 : Conversion to a Monocyte Chemotactic Factor by a Factor XIIIa-Catalyzed Reaction on Activated Platelet Membrane Phosphatidylserine in Association with Blood Coagulation2010
Author(s)
Semba, U., Chen, J., Ota, Y., Jia, N., Arima, H., Nishiura, H., and Yamamoto, T.
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Journal Title
Am. J. Pathol.
Volume: 176
Pages: 542-1551
Related Report
Peer Reviewed
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[Journal Article] Pro-and anti-apoptotic dual functions of the C5a receptor : Involvement of regulator of G protein signaling 3 and extracellular signal-regulated kinase2009
Author(s)
Nishiura, H., Nonaka, H., Revollo, I., Semba, U., Li, Y., Irie, A., Harada, K., Kehrl, J. H. and Yamamoto, T.
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Journal Title
Lab. Invest.
Volume: 89
Pages: 676-694
Related Report
Peer Reviewed
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