New molecular therapy against gastroenterological malignancies targeting members of HER and VEGF family
| Project/Area Number |
21590457
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Aichi Cancer Center Research Institute |
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Principal Investigator |
NAKANISHI Hayao 愛知県がんセンター(研究所), 腫瘍病理学部, 室長 (20207830)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 腫瘍 / ERFR / HER2 / HER3 / VEGF / 胃癌・大腸癌 / Gefitinib |
|---|
| Research Abstract |
In this study, we newly demonstrated following three findings. 1) HER3 is involved in the gefitinib-sensitivity of pooly-differentiated colonic cancer cell line (COLM-5).
2) VEGF-A is overexpressed in some HER2 gene-amplified gastric cancer cell lines and can be effectively targeted by bevacizumab alone and in combination with HER2 antagonists.
3) Subline showing EMT derived from parental HNSCC show gefitinib-resistance due to down regulation of EGFR and compensatory activation of alternative signaling pathway.
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Report
(4 results)
Research Products
(50 results)
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[Journal Article] TGF-β synergizes with defects in the Hippo pathway to stimulate human malignant mesothelioma growth2012
Author(s)
Fujii M, Toyoda T, Nakanishi H, Yatabe Y, Sato A, Matsudaira Y, Ito H, Murakami H, Kondo Y, Kondo E, Hida T, Tsujimura T, Osada H, Sekido Y.
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Journal Title
J Exp Med
Volume: VOL.209(3)
Issue: 3
Pages: 479-494
DOI
Related Report
Peer Reviewed
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[Journal Article] Expression and the role of 3'-phosphoadenosine 5'-phosphosulfate transporters in human colorectal carcinoma2011
Author(s)
Kamiyama S, Ichimiya T, Ikehara Y, Takase T, Fujimoto I, Suda T, Nakamori S, Nakamura M, Nakayama F, Irimura T, Nakanishi H, Watanabe M, Narimatsu H, Nishihara S.
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Journal Title
Glycobiology
Volume: VOL.21(2)
Issue: 2
Pages: 235-246
DOI
Related Report
Peer Reviewed
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