| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
The fungus Candida albicans colonizes the mucosal tissue of the oral cavity and the gastrointestinal tract, where it is part of the normal commensal microflora. However, under immune-compromised conditions, it can cause local and systemic candidiasis. To understand host defense mechanism against Candida, we analysed the interaction of signaling between TLR9 and dectin-2.As a result, we observed the collaborative induction of immune responses by these two receptors, which regulated the immunological status of the host during Candida albicans infection.
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