• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Identification of the virulence factors associated with Helicobacter heilmannii-induced gastric MALT lymphoma

Research Project

Project/Area Number 21590491
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Bacteriology (including Mycology)
Research InstitutionKitasato University

Principal Investigator

MATSUI Hidenori  北里大学, 大学院・感染制御科学府, 講師 (30219373)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsHelicobacter heilmannii / 胃MALTリンパ腫 / ゲノム解析 / 病原性 / ヘリコバクター / MALTリンパ腫 / 人獣共通感染症 / マウス感染モデル / マウス感染実験 / ナノサイズ免疫磁気ビーズ / マイクロアレイ / 胃バイオプシー
Research Abstract

The genomic DNA was prepared from gastric homogenates of mice infected with H. heilmannii TKY or H. suis SNTW10 by using immunomgnetic beads(Sepa-Max Hp). Greater than 110 bases were sequenced of each strain by ABI SOLiD 4 system. Comparative analysis of newly sequenced genomes to the existing reference genomes of Helicobacter species enabled the identification of several H. heilmannii-specific virulence genes.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (87 results)

All 2012 2011 2010 2009

All Journal Article (35 results) (of which Peer Reviewed: 22 results) Presentation (52 results)

  • [Journal Article] 胃、肝MALTリンパ腫形成および進展における幹細胞の関与2012

    • Author(s)
      中村正彦、高橋哲史、横山展子、松田唯、松井英則、土本寛二
    • Journal Title

      Prog. Med

      Volume: 32 Pages: 553-555

    • Related Report
      2011 Final Research Report
  • [Journal Article] Neonatal Fc receptor for IgG (FcRn) expressed in the gastric epithelium regulates bacterial infection in mice2012

    • Author(s)
      Suleiyman YB, Yoshida M, Tanaka H, Nishiumi S, Mimura T, Nobutani K, Yamamoto K, Takenaka M, Ota H, Takahashi S, Matsui H, Nakamura M, Blumberg RS, Azuma T
    • Journal Title

      Mucosal Immunol

      Volume: 5 Issue: 1 Pages: 87-98

    • DOI

      10.1038/mi.2011.53

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A CD46 transgenic mouse model for studying the histopathology of arthritis caused by subcutaneous infection with Streptococcus dysgalactiae subspecies equisimilis2012

    • Author(s)
      Yoshida, H., Matsui, H.Murayama, S.Y., Takada, Y., Matsuo, K.Takahashi, T., Nakamura, M., Ubukata, K., Takahashi, T.
    • Journal Title

      J.Med.Microb.

      Volume: 60 Issue: 12 Pages: 1860-1868

    • DOI

      10.1099/jmm.0.034108-0

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 免疫磁気ビーズによる食肉中の腸管出血性大腸菌O157,O26,O111の迅速検出法の展開2012

    • Author(s)
      松井英則
    • Journal Title

      食品と開発

      Volume: 47 Pages: 36-37

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Infectious diseases after the 2011 Great East Japan Earthquake2012

    • Author(s)
      Takahashi T, Goto M, Yoshida H, Sumino H, Matsui H
    • Journal Title

      J Exp Clin Med

      Volume: 4 Issue: 1 Pages: 20-23

    • DOI

      10.1016/j.jecm.2011.11.013

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] レンサ球菌性軟部組織壊死における肥満細胞の役割2012

    • Author(s)
      松井英則、吉田春乃、高橋孝
    • Journal Title

      Medical Practice

      Volume: 29 Pages: 340-340

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 胃、肝MALTリンパ腫形成および進展における幹細胞の関与2012

    • Author(s)
      中村正彦、高橋哲史、横山展子、松田唯、松井英則、土本寛二
    • Journal Title

      Prog.Med.

      Volume: 32 Pages: 553-555

    • Related Report
      2011 Annual Research Report
  • [Journal Article] ヘリコバクター・ハイルマニー感染とは"One Point Advice"2011

    • Author(s)
      松井英則、高橋孝、中村正彦
    • Journal Title

      Medical Practice

      Volume: 28(6) Pages: 1123-1123

    • Related Report
      2011 Final Research Report
  • [Journal Article] ヘリコバクター・ハイルマニー感染とは2011

    • Author(s)
      松井英則、高橋孝、中村正彦
    • Journal Title

      Medical Practice

      Volume: 28 Pages: 1123-1123

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Helicobacter heilmannii感染による胃MALTリンパ腫発症機構の解明とIL-10の役割2011

    • Author(s)
      高橋哲史, 松井英則, 瀧沢麻子, 品川桂子, 小松陽子, 高橋信一, 中村正彦, 上本寛二
    • Journal Title

      潰瘍

      Volume: 38 Pages: 118-120

    • NAID

      10029742853

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 免疫磁気ビーズ法による肉検体からの腸管出血性大腸菌血清型O111分離の検討2011

    • Author(s)
      松井英則、吉田春乃、高橋孝
    • Journal Title

      感染症学雑誌

      Volume: 85 Pages: 540-542

    • NAID

      10030236276

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 胃MALTリンパ腫形成および進展におけるstem cellの関与-PCNA,DCAMKL-1免疫活性2011

    • Author(s)
      中村正彦、高橋哲史、松井英則、土本寛二
    • Journal Title

      潰瘍

      Volume: 38 Pages: 128-129

    • NAID

      10029742887

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Darmal mast cells reduce progressive tissue necrosis caused by subcutaneous infection with Streptococcus pyogenes in mice2011

    • Author(s)
      Hidenori Matsui, Yukie Sekiya, Tetsufumi Takahashi, Masahiko Nakamura, Ken'ichi Imanishi, Haruno Yoshida, Somay Tamagata Kurayama, Takashi Takahashi, Kanji Tsuchimoto, Takehiko Uchiyama, Kimiko Ubukata.
    • Journal Title

      Journal of Medical Microbiology

      Volume: 60 Pages: 128-134

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Candidatus Helicobacter heilmannii infection in the course of gastric mucosa-associated lymphoid tissue(MALT) lymphoma in human beings and mouse models2010

    • Author(s)
      Hidenori Matsui, Yukie Sekiya, Chihiro Aikawa, Soamy Yamagata Murayama, Tetsufumi Takahashi, Haruno Yoshida, Takashi Takahashi, Kanji Tsuchimoto, and Masahiko Nakamura
    • Journal Title

      Current Trends in Microbiology

      Volume: 6 Pages: 27-34

    • Related Report
      2011 Final Research Report
  • [Journal Article] Helicobacter heilmanniiと胃MALTリンパ腫-brain-gutペプチド,とくにCGRPの関連性について-2010

    • Author(s)
      中村正彦、高橋哲史、松井英則、土本寛二
    • Journal Title

      Helicobacter Research

      Volume: 14(2) Pages: 11-14

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Journal Article] Helicobacter heilmannii臨床分離株の分離と病原性の検討2010

    • Author(s)
      高橋哲史、松井英則、村山そう明、中村真一、白鳥敬子、土本寛二、中村正彦
    • Journal Title

      潰瘍(Ulcer Research)

      Volume: 37(1) Pages: 46-49

    • Related Report
      2011 Final Research Report
  • [Journal Article] Helicobacter heilmannii臨床分離株の分離と病原性の検討2010

    • Author(s)
      高橋哲史、松井英則、村山そう明、中村真一、白鳥敬子、土本寛二、中村正彦
    • Journal Title

      潰瘍

      Volume: 37 Pages: 46-49

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Helicobacter pyloriとNeisseria subflavaの混合感染の意義2010

    • Author(s)
      中村正彦、高橋哲史、松井英則、村山そう明、芹澤宏、土本寛二
    • Journal Title

      Helicobacter Research

      Volume: 14 Pages: 13-16

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ナノサイズ免疫磁気ビーズと従来の免疫磁気ビーズを用いた食品検体からの腸管出血性大腸菌の分離の比較について2010

    • Author(s)
      吉田春乃、松井英則
    • Journal Title

      医療と検査機器・試薬

      Volume: 33 Pages: 241-245

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 鳥肌胃炎形成とHelicobacter heilmannii-like organism感染の関連の検討2010

    • Author(s)
      中村正彦、高橋哲史、松井英則、中村真一、白鳥敬子、高橋信一、土本寛二
    • Journal Title

      Progress in Medicine

      Volume: 30 Pages: 781-783

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Helicobacter heilmanniican induce gastric lymphoid follicles in mice via a Peyer's Patche-independent pathway2010

    • Author(s)
      Kentaro, Nobutani, Masaru Yoshida, Shin Nishiumi, Yosuke Nishitani, Tetsuya Takagawa Horoshi Tanaka, Koji Yamamoto, Takuya Miura, Yahaya Bensuleiman, Hiroshi Ota, Shinichi Takahashi, Hidenori Matsui, Masahiko Nakamur, Takeshi Azuma
    • Journal Title

      FEMS Immunology & Medical Microbiology

      Volume: 60 Pages: 156-164

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Candidatus Helicobacter heilmannii" infection in the course of gastric mucosa-associated lymphoid tissue(MALT)lymphoma in human beings and mouse models.2010

    • Author(s)
      Hidenori Matsui, Yukie Sekiya, Chihiro Aikawa, Seamy Tamagata Murayama, Tetsufumi Takahashi, Haruno Yoshida, Takashi Takahashi, Kanji Tsuchimoto, Masahiko Nakamura.
    • Journal Title

      Current Trends in Microbiology

      Volume: 6 Pages: 27-34

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Helicobacter heilmanniiと胃リンパ腫-brain-gut peptide,特にCGRPの関連性について2010

    • Author(s)
      中村正彦、高橋哲史、松井英則、土本寛二
    • Journal Title

      Helicobacter Research

      Volume: 14 Pages: 91-94

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Helicobacter pyloriとNeisseria subflavaの混合感染の意義2010

    • Author(s)
      中村正彦, 他
    • Journal Title

      Helicobacter Research 14

      Pages: 13-16

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of lymphangiogenesis induced by Flt -4 antibody in gastric low-grade MALT lymphoma by Helicobacter heilmannii infection.2010

    • Author(s)
      Nakamura, M., et al.
    • Journal Title

      Journal of Gastroenterology and Hepatology 25(Suppl. 1)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Helicobacter heilmanniiと胃MALTリンパ腫-brain-gutペプチド,とくにCGRPの関連性について-2010

    • Author(s)
      中村正彦, 他
    • Journal Title

      Helicobacter Research 14

      Pages: 241-245

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ナノサイズ免疫磁気ビーズと従来の免疫磁気ビーズを用いた食品検体からの腸管出血性大腸菌の分離の比較について2010

    • Author(s)
      吉田春乃、松井英則
    • Journal Title

      医療と検査機器・試薬 33

      Pages: 241-245

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Helicobacter heilmannii感染時のNSAIDs消化管傷害2009

    • Author(s)
      中村正彦、高橋哲史、松井英則、土本寛二
    • Journal Title

      潰瘍(Ulcer Research)

      Volume: 26 Pages: 26-29

    • NAID

      10025371494

    • Related Report
      2011 Final Research Report
  • [Journal Article] Helicobacter heilmanniiと胃MALTリンパ腫2009

    • Author(s)
      中村正彦、高橋哲史、田村亮、小川智史、松井英則、土本寛二
    • Journal Title

      Helicobacter Research

      Volume: 13(4) Pages: 302-305

    • Related Report
      2011 Final Research Report
  • [Journal Article] Helicobacter heilmanniiと胃MALTリンパ腫2009

    • Author(s)
      中村正彦, 他
    • Journal Title

      Helicobacter Research 13

      Pages: 302-305

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Helicobacter heilmannii感染による胃MALTリンパ腫のリンパ管新生機序2009

    • Author(s)
      小川智史, 他
    • Journal Title

      潰瘍 36

      Pages: 175-178

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Helicobacter heilmannii感染時のNSAIDs消化管傷害2009

    • Author(s)
      中村正彦, 他
    • Journal Title

      潰瘍 36

      Pages: 26-29

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CD46 transgenic mouse model of necrotizing fasciitis caused by Streptococcus pyogenes infection.2009

    • Author(s)
      Matsui, H., et al.
    • Journal Title

      Infection and Immunity 77

      Pages: 4806-4814

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 熱応答性磁性ナノ粒子を用いた細菌分離法2009

    • Author(s)
      高橋哲史, 他
    • Journal Title

      Medical Technology 37

      Pages: 224-225

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Helicobacter heilmanniiによる胃MALTリンパ腫増大に伴うリンパ管新生2009

    • Author(s)
      長谷川絢央, 他
    • Journal Title

      Progress in Medicine 29

      Pages: 751-754

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] The role of IL-5 in protecting mice against Salmonella infection2012

    • Author(s)
      江口正浩、菊池雄士、小川洋介、下地善弘、山本友子、松井英則
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎ブリックホール
    • Year and Date
      2012-03-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] Helicobacter heilmannii感染による胃MALTリンパ腫2012

    • Author(s)
      高橋哲史, 松井英則, 瀧沢麻子, 高橋信一, 中村正彦, 土本寛二
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道大学札幌キャンパス
    • Year and Date
      2012-03-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] 日本におけるPCR法を用いた胃生検体からのHelicobacter heilmannii DNAの検出(Detection of Helicobacter heilmannii DNA in gastric biopsy specimens by PCR in Japan2012

    • Author(s)
      関谷幸江、中谷百合子、吉田春乃、村山そう明、中村正彦、松井英則
    • Organizer
      85回日本細菌学会総会
    • Place of Presentation
      長崎ブリックホール・長崎新聞分化ホール
    • Year and Date
      2012-03-27
    • Related Report
      2011 Final Research Report
  • [Presentation] Detection of Helicobacter heilmannii DNA in gastric biopsy specimens by PCR in Japan2012

    • Author(s)
      関谷幸江、中谷百合子、吉田春乃、村山そう明、中村正彦、松井英則
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎ブリックホール
    • Year and Date
      2012-03-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] Osteonecrosis in CD46 Tg mice caused by S.pyogenes infection is T cell-derived RANKL independent2012

    • Author(s)
      中谷百合子、松井英則、吉田春乃、関谷幸江、村山そう明、中村正彦、生方公子
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎ブリックホール
    • Year and Date
      2012-03-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] Angiogenesis and lymphangiogenesis in hepatic and pulmonary MALT lymphoma in Helicobacter heilmannii-infected mouse : effect of eradication of bacill2012

    • Author(s)
      Nakamura, M., Matsui, H., Takahashi, T., Tsuchimoto, K.
    • Organizer
      37^<th> Annual Meeting of the Japanese Society for Microcirculation
    • Place of Presentation
      盛岡グランドホテル
    • Year and Date
      2012-03-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Helicobacter heilmannii感染による胃MALTリンパ腫病態形成時における宿主遺伝子発現の解析2011

    • Author(s)
      高橋哲史, 中村正彦, 松井英則, 関谷幸江, 土本寛二
    • Organizer
      第39回日本潰瘍学会
    • Place of Presentation
      つくば国際会議場
    • Year and Date
      2011-11-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] 胃、肝、肺MALTリンパ腫形成および進展における微小循環系の関与-c-MET,HGFとの関連-2011

    • Author(s)
      中村正彦、高橋哲文史,松井英則、土本寛二
    • Organizer
      第39回日本潰瘍学会
    • Place of Presentation
      つくば国際会議場
    • Year and Date
      2011-11-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] Altered Microvascular Network in Hepatic MALT lymphoma in Helicobacter heilmannii-infected Mouse2011

    • Author(s)
      Nakamura, M., Matsui, H., Takahashi, T., Tsuchimoto, K
    • Organizer
      8th Asian Congress for Microcirculation
    • Place of Presentation
      Bangkok
    • Year and Date
      2011-10-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] CD46トランスジェニックマウスを用いた溶血性レンサ球菌感染症の研究2011

    • Author(s)
      松井英則, 的場時代, 吉田春乃, 関谷幸江, 村山そう明, 高田康成, 瀧沢麻子, 竹内修, 高橋哲史, 中村正彦, 今西健一, 内山竹彦, 松尾光二, 生方公子, 高橋孝
    • Organizer
      第94回日本細菌学会関東支部総会
    • Place of Presentation
      北里大学本館大講堂
    • Year and Date
      2011-10-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] 鳥肌胃炎形成とHelicobacter suis感染の関連-臨床例からの菌の分離および感染モデル2011

    • Author(s)
      中村正彦、高橋哲史、松井英則、高橋信一、上本寛二
    • Organizer
      第9回胃の形態と機能研究会
    • Place of Presentation
      シェラトン都ホテル(東京)
    • Year and Date
      2011-10-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] CD46 transgenic mouse model of acute severe invasive infections caused by Streptococcus pyogenes2011

    • Author(s)
      H.Matsui, H.Yoshida, S.Y.Murayama, A.Takizawa, O.Takeuchi, T.Takahashi, M.Nakamura, K.Imanishi, T.Uchiyama, T.Takahashi, K.Ubukata
    • Organizer
      International Union of Microbiological Societies (IUMS) 2011
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2011-09-07
    • Related Report
      2011 Annual Research Report
  • [Presentation] 胃リンパ腫をターゲットとした各種モノクローナル抗体による抗腫瘍効果について2011

    • Author(s)
      中村正彦、高橋哲史、松井英則、土本寛二
    • Organizer
      生体機能と創薬シンポジウム2011
    • Place of Presentation
      長井記念館(東京)
    • Year and Date
      2011-09-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] Helicobacter heilmannii感染に対する宿主応答因子の網羅的解析2011

    • Author(s)
      中村正彦,高橋哲史、松井英則、土本寛二
    • Organizer
      第30回消化器病態生理勉強会
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2011-07-31
    • Related Report
      2011 Annual Research Report
  • [Presentation] Helicobacter heilmannii長期感染におけると肝、肺マルトリンパ腫形成-stem cellからみた特徴および除菌の効果2011

    • Author(s)
      中村正彦、松井英則、高橋哲史、芹沢宏、高橋信一、土本寛二
    • Organizer
      第17回日本ヘリコバクター学会学術集会
    • Place of Presentation
      富山国際会議場
    • Year and Date
      2011-06-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] Helicobacter heilmannii感染によるB細胞活性化機構の解析2011

    • Author(s)
      高橋哲史、松井英則、瀧沢麻子、高橋信一、土本寛二、中村正彦
    • Organizer
      第17回日本ヘリコバクター学会学術集会
    • Place of Presentation
      富山国際会議場
    • Year and Date
      2011-06-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] 胃粘膜微小循環系-潰瘍形成、MALTリンパ腫における変化-。シンポジウム25血管2011

    • Author(s)
      中村正彦、松井英則、土本寛二
    • Organizer
      日本顕微鏡学会第67回学術講演会
    • Place of Presentation
      福岡
    • Year and Date
      2011-05-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Molecular mechanism of gastric MALT lymphoma formation by Helicobacter heilmannii infection2011

    • Author(s)
      Takahashi, T., Matsui, H., Takizawa A, Takahashi, S., Hibi, T., Nakamura, M., Tsuchimoto, K.
    • Organizer
      Digestive Disease Week (DDW) 2011
    • Place of Presentation
      Chicago IL, USA
    • Year and Date
      2011-05-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] Hepatic and pulmonary MALT Lymphoma formation in Helicobacter heilmannii-infected mice : Relation to gastric MALToma and effects of eradication2011

    • Author(s)
      Nakamura, M., Matsui, H., Takahashi, Murayama, S.Y., Takahashi, S., Hibi, T., Tsuchimoto, K.
    • Organizer
      Digestive Disease Week (DDW)2011
    • Place of Presentation
      Chicago IL, USA
    • Year and Date
      2011-05-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] MALT Lymphoma Stem Cells in H.heilmannii-infected Mice2011

    • Author(s)
      Nakamura, M., Matsui, H., Takahashi, T., Murayama, S.Y., Takahashi, S., Hibi, T., Tsuchimoto, K.
    • Organizer
      Digestive Disease Week (DDW) 2011
    • Place of Presentation
      Chicago IL, USA
    • Year and Date
      2011-05-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] Molecular mechanism of gastric MALT lymphoma formation by Helicobacter heilmannii infection2011

    • Author(s)
      Takahashi, T., Matsui, H., Takizawa A, Takahashi, S., Hibi, T., Nakamura, M., and Tsuchimoto, K
    • Organizer
      Digestive Disease Week(DDW) 2011
    • Place of Presentation
      Chicago IL, USA
    • Year and Date
      2011-05-07
    • Related Report
      2011 Final Research Report
  • [Presentation] 劇症型A群溶血性レンサ球菌感染に及ぼす肥満細胞の役割2011

    • Author(s)
      松井英則、吉田春乃、村山そう明、高橋孝、生方公子
    • Organizer
      第85回日本感染症学会総会
    • Place of Presentation
      ザ・プリンスパークタワー東京
    • Year and Date
      2011-04-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] 劇症型A群溶血性レンサ球菌感染症における骨壊死発症機構の解析2011

    • Author(s)
      吉田春乃、松井英則、村山そう明、生方公子、高橋孝
    • Organizer
      第85回日本感染症学会総会
    • Place of Presentation
      ザ・プリンスパークタワー東京
    • Year and Date
      2011-04-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] Helicobacter heilmannii感染による胃MALTリンパ腫発症機構の解明2011

    • Author(s)
      高橋哲史, 松井英則, 瀧沢麻子, 小松陽子, 品川桂子, 中村正彦, 土本寛二
    • Organizer
      日本薬学会 第131年会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] Helicobacter heilmannii長期感染における胃マルトリンパ腫と肝、病変形成2011

    • Author(s)
      中村正彦、松井英則、高橋哲史、芹沢宏、高橋信一、土本寛二
    • Organizer
      Cytoperotection研究会
    • Place of Presentation
      京都
    • Year and Date
      2011-03-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] Helicobacter heilmannii長期感染における肝、肺病変形成-除菌療法の効果-2011

    • Author(s)
      中村正彦、松井英則、高橋哲史、芹沢宏、高橋信一、土本寛二
    • Organizer
      第7回日本消化管学会
    • Place of Presentation
      京都
    • Year and Date
      2011-02-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] Altered microvascular network in hepatic MALT lymphoma in Helicobacter heilmannii-infected mouse.2011

    • Author(s)
      Nakamura, M., Matsui, H., Takahashi, T., Tsuchimoto, K
    • Organizer
      第36回日本微小循環学会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-02-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] Helicobacter heilmannii感染時における宿主の遺伝子活性化機構の解析2010

    • Author(s)
      高橋哲史、中村正彦、松井英則、高橋信一、土本寛二
    • Organizer
      第38回日本潰瘍学会
    • Place of Presentation
      大阪
    • Year and Date
      2010-11-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] 胃MALTリンパ腫肝臓転移組織内における自律神経分布-CGRP、nNOS, GAP43, Synaptophysin免疫活性による検討2010

    • Author(s)
      中村正彦、松井英則、高橋哲史、土本寛二
    • Organizer
      第63回日本自律神経学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2010-10-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 胃MALTリンパ腫におけるstem cellの関与-PCNA, DCAMKL-1免疫活性およびcelecoxibの効果。ワークショップ6消化器がんの臨床における分子形態学の役割2010

    • Author(s)
      中村正彦、松井英則、高橋哲史、土本寛二
    • Organizer
      第42回日本臨床分子形態学会総会・学術集会
    • Place of Presentation
      三島
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] High prevalence of hepatic and lung metastasis of gastric MALT lymphoma in Helicobacter heilmannii-infected mice.2010

    • Author(s)
      Nakamura, M., Matsui.H., Takahashi, T., Serizawa, H., Takahashi, S., Tsuchimoto, K
    • Organizer
      XXIIIrd International Workshop on Helicobacter pylori and related bacteria in chronic digestive inflammation and gastric cancer
    • Place of Presentation
      Rotterdam
    • Year and Date
      2010-09-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] NSAIDs小腸粘膜傷害形成におけるHelicobacter属および乳酸菌の関与2010

    • Author(s)
      中村正彦、高橋哲史、松井英則、土本寛二
    • Organizer
      第1回GI-Metabolism Forum
    • Place of Presentation
      京都
    • Year and Date
      2010-08-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] Helicobacter heilmannii長期感染における肺、肝病変形成2010

    • Author(s)
      中村正彦、松井英則、高橋哲史、芹沢宏、高橋信一、土本寛二
    • Organizer
      第16回日本ヘリコバクター学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2010-06-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] Helicobacler heilmannii感染に対する宿主応答因子の網羅的解析2010

    • Author(s)
      高橋哲史、中村正彦、訟井英則、村山そう明、高橋信一、土本寛二
    • Organizer
      第16回日本ヘリコバクター学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2010-06-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] Molecular pathogenesis of Helicobacter suis strains SNTW101 from a patient suffering from nodular gastritis2010

    • Author(s)
      Takahashi, T., Matsui, H., Murayama, S.Y., Nakamura, S., Shiratori, K., Tsuchimoto, K
    • Organizer
      DDW
    • Place of Presentation
      New Orleans
    • Year and Date
      2010-05-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] Significance of Helicobacter suis As a Pathogen of Nodular Gastritis : Relation to MALT Lymphoma2010

    • Author(s)
      Nakamura, M., Takahashi, Y., Matsui, H., Nakamura, S., Takahashi, S., Shiratori, K., Murayama, S.Y., Tsuchimoto, K.
    • Organizer
      DDW
    • Place of Presentation
      New Orleans
    • Year and Date
      2010-05-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] Helicobacter heilmannii Infection Induces Alteration of Stem Cell Environment As Well As Delayed Healing in Acetic Acid Ulcer2010

    • Author(s)
      Nakamura, M., Takahashi, T., Matsui, H., Takahashi, S., Tsuchimoto, K.
    • Organizer
      DDW
    • Place of Presentation
      New Orleans
    • Year and Date
      2010-05-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] CD46トランスジェニックマウスを用いたStreptococcus dysgalactiae subsp.equisimilis(SDSE)感染モデルの構築2010

    • Author(s)
      松井英則、吉田春乃、岡田圭祐、村山〓明、生方公子
    • Organizer
      第84回日本感染症学会総会
    • Place of Presentation
      京都
    • Year and Date
      2010-04-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] Gastric MALT lymphomas in mice infected with HHLO from apatient with nodular gastritis2010

    • Author(s)
      Takahashi, T, et al.
    • Organizer
      第83回日本細菌学会総会
    • Place of Presentation
      Yokohama
    • Year and Date
      2010-03-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] Protective roles of skin mast cells in mouse models of necrotizing fasciitis caused by GAS infection2010

    • Author(s)
      Yoshida, H., et al.
    • Organizer
      第83回日本細菌学会総会
    • Place of Presentation
      Yokohama
    • Year and Date
      2010-03-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] Experimental model of Streptococcus dysgalactiae subsp. equisimilis infection in CD46 transgenic mice2010

    • Author(s)
      Okada, K., et al.
    • Organizer
      第83回日本細菌学会総会
    • Place of Presentation
      Yokohama
    • Year and Date
      2010-03-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] マウス胃MALTリンパ腫に対するcelecoxibおよびFlt-1,Flk-1,Flt-4抗体の効果2010

    • Author(s)
      中村正彦, 他
    • Organizer
      第6回日本消化管学会総会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2010-02-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] Helicobacter suis induces nodular gastritits : relation to MALT lymphoma2010

    • Author(s)
      Nkamura, M., et al.
    • Organizer
      5^<th> Collaboration meeting on GI pharmacology
    • Place of Presentation
      Kyoto
    • Year and Date
      2010-02-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] マウス胃MALTリンパ腫に対するcelecoxibおよびFlt-1, Flk-1, Flt-4抗体の効果2010

    • Author(s)
      中村正彦、高橋哲史、松井英則、土本寛二
    • Organizer
      第6回日本消化管学会総会学術集会
    • Place of Presentation
      福岡
    • Related Report
      2011 Final Research Report
  • [Presentation] Helicobacter heilmannii臨床株の分離と病原性の検討2009

    • Author(s)
      高橋哲史, 他
    • Organizer
      第37回日本潰瘍学会
    • Place of Presentation
      東京
    • Year and Date
      2009-11-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] 胃MALTリンパ腫に対するcelecoxibの効果-血管、リンパ管新生の抑制-2009

    • Author(s)
      中村正彦, 他
    • Organizer
      第41回日本臨床分子形態学会
    • Place of Presentation
      福岡
    • Year and Date
      2009-09-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] 鳥肌胃炎とHelicobacter heilmannii2009

    • Author(s)
      中村正彦, 他
    • Organizer
      第28回消化器病態生理勉強会
    • Place of Presentation
      東京
    • Year and Date
      2009-08-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] 鳥肌胃炎発生機転におけるHelicobacter heilmannii like organismの関連2009

    • Author(s)
      中村正彦, 他
    • Organizer
      第15回日本ヘリコバクター学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-06-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] Effect of Celecoxib on the Suppression of Gastric Low-grade MALT Lymphoma Induced by Helicobacter heilmannii Infection2009

    • Author(s)
      Nakamura, M., et al.
    • Organizer
      DDW
    • Place of Presentation
      Chicago
    • Year and Date
      2009-05-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒトCD46発現マウスを用いた実験的劇症型A群溶血性レンサ球菌感染症の解析.2009

    • Author(s)
      松井英則, 他
    • Organizer
      第83回日本感染症学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-04-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] Maturation of Fundic Glandular Cells are Markedly Altered in IL-10(-/-)mice2009

    • Author(s)
      Takahashi, T., et al
    • Organizer
      13th Taisho-Toyama International Symposium on Gastroenterology
    • Place of Presentation
      Shimoda
    • Year and Date
      2009-04-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] IL-10 Knockout and not Deficiency Suppresses Gastric Low -Grade MALT Lymphoma Formation by Helicobacter heilmannii Infection2009

    • Author(s)
      Nakamura, M., et al.
    • Organizer
      13th Taisho-Toyama International Symposium on Gastroenterology
    • Place of Presentation
      Shimoda
    • Year and Date
      2009-04-17
    • Related Report
      2009 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi