Research for Immunotherapy of Adult T cell Leukemia(ATL)

• Project/Area Number: 21590521
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Virology
• Research Institution: National Institute of Infectious Diseases
• Principal Investigator: HASEGAWA Hideki 国立感染症研究所, 感染病理部, 部長 (30301790)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: ウイルス / 感染症 / 免疫学

Research Abstract

Adult T-cell Leukemia(ATL) is a refractory disease. It is suggested that the treatment resistant cancer stem cells are present in the leukemic cells population. We have attempted to identify molecules that can be a target for immunotherapy which target the cancer stem cells using a mouse model of ATL. We identified molecules that are specifically expressed on the surface of cancer stem cells of mouse ATL cells by multi TOF MASS analyzer. The molecule can be a therapeutic target of ATL.

Research Products

• [Journal Article] Mechanism of Drug Resistance of Hemagglutinin of Influenza Virus and Potent Scaffolds Inhibiting Its Function (2012)
  • Author(s): Yanagita H, Yamamoto N, Fuji H, Liu X, Ogata M, Yokota M, Takaku H, Hasegawa H, Odagiri T, Tashiro M, Hoshino T
  • Journal Title: ACS Chem Biol Volume: 7(3) Pages: 552-562
• [Journal Article] A novel function of the N-terminal domain of PA in assembly of influenza A virus RNA polymerase (2011)
  • Author(s): Suzuki T, Ainai A, Nagata N, Sata T, Sawa H, Hasegawa H.
  • Journal Title: Biochem Biophys Res Commun Volume: 414(4) Pages: 719-726
• [Journal Article] A novel function of the N-terminal domain of PA in assembly of influenza Avirus RNA polymerase (2011)
  • Author(s): Suzuki T, Ainai A, Nagata N, Sata T, Sawa H, Hasegawa H
  • Journal Title: Biochem Biophys Res Commun Volume: 414(4) Issue: 4 Pages: 719-726
  • DOI: 10.1016/j.bbrc.2011.09.142
  • Peer Reviewed
• [Journal Article] Therapy-induced selective loss of leukemia-initiating activity in murine adult T cell leukemia (2010)
  • Author(s): El Hajj H, El-Sabban M, Hasegawa H, Zaatari G, Ablain J, Saab ST, Janin A, Mahfouz R, Nasr R, Kfoury Y, Nicot C, Hermine O, Hall W, de The H, Bazarbachi A
  • Journal Title: J Exp Med Volume: 207 Pages: 2785-92
• [Journal Article] Functional analysis of an alpha-helical antimicrobial peptide derived from a novel mouse defensin-like gene (2010)
  • Author(s): Kawaguchi A, Suzuki T, Kimura T, Sakai N, Ayabe T, Sawa H, Hasegawa
  • Journal Title: Biochem Biophys Res Commun Volume: 398 Pages: 778-84
• [Journal Article] Sheehy N Cytokine and growth factor expression by HTLV-1 Lck-tax transgenic cells in SCID mice (2010)
  • Author(s): Watters KM, Dean J, Hasegawa H, Sawa H, Hall W
  • Journal Title: AIDS Res Hum Retrovir Volume: 26 Pages: 593-603
• [Journal Article] Therapy-induced selective loss of leukemia-initiating activity in murine adult T cell leukemia. (2010)
  • Author(s): El Hajj H, El-Sabban M, Hasegawa H, Zaatari G, Ablain J, Saab ST, Janin A, Mahfouz R, Nasr R, Kfoury Y, Nicot C, Hermine O, Hall W, de The H, Bazarbachi A
  • Journal Title: J Exp Med Volume: 207 Pages: 2785-92
  • Peer Reviewed
• [Journal Article] Functional analysis of an alpha-helical antimicrobial peptide derived from a novel mouse defensin-like gene. (2010)
  • Author(s): Kawaguchi A, Suzuki T, Kimura T, Sakai N, Ayabe T, Sawa H, Hasegawa H
  • Journal Title: Biochem Biophys Res Commun Volume: 398 Pages: 778-784
  • Peer Reviewed
• [Journal Article] Cytokine and growth factor expression by HTLV-1 Lck-tax transgenic ceUs in SCID mice. (2010)
  • Author(s): Watters KM, Dean J, Hasegawa H, Sawa H, Hall W, Sheehy N
  • Journal Title: AIDS Res Hum Retrovir Volume: 26 Pages: 593-603
  • Peer Reviewed
• [Journal Article] Identification of Cancer Stem Cells in a Tax-transgenic(Tax-Tg) Mouse Model of Adult T-Cell Leukemia/lymphoma(ATL) (2009)
  • Author(s): Yamazaki J, Mizukami T, Takizawa K, Kuramitsu M, Momose H, Masumi A, Ami Y, Hasegawa H, Hall W. W, Tsujimoto H, Hamaguchi I, Yamaguchi K
  • Journal Title: Blood Volume: 114(13) Pages: 2709-2720
• [Journal Article] Inhibition of the SDF-1α-CXCR4 axis by the CXCR4 antagonist AMD3100 suppresses the migration of cultured cells from ATL patients and murine lymphoblastoid cells from HTLV-I Tax transgenic mice (2009)
  • Author(s): Kawaguchi A, Orba Y, Kimura T, Iha H, Ogata M, Tsuji T, Ainai A, Sata T, Okamoto T, Hall WW, Sawa H, Hasegawa H
  • Journal Title: Blood Volume: 114(14) Pages: 2961-2968
• [Journal Article] Identification of Cancer Stem Cells in a Tax-transgenic(Tax-Tg)Mouse Model of Adult T-Cell Leukemia/lymphoma(ATL) (2009)
  • Author(s): Yamazaki J, Mizukami T, Takizawa K, Kuramitsu M, Momose H, Masumi A, Ami Y, Hasegawa H, Hall W.W, Tsujimoto H, Hamaguchi I, Yamaguchi K
  • Journal Title: Blood 114(13) Pages: 2709-2720
  • Peer Reviewed
• [Journal Article] Inhibition of the SDF-1α-CXCR4 axis by the CXCR4 antagonist AMD3100 suppresses the migration of cultured cells from ATL patients and murine lymphoblastoid cells from HTLV-I Tax transgenic mice (2009)
  • Author(s): Kawaguchi A, Orba Y, Kimura T, Iha H, Ogata M, Tsuji T, Ainai A, Sata T, Okamoto T, Hall W.W, Sawa H, Hasegawa H
  • Journal Title: Blood 114(14) Pages: 2961-2968
  • Peer Reviewed
• [Presentation] 原人T細胞性白血病(ATL)モデルマウスを用いた新規治療法の試み (2011)
  • Author(s): 長谷川秀樹
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2011-04-30
• [Presentation] 成人T細胞性白血病(ATL)モデルマウスを用いた新規治療法の試み (2011)
  • Author(s): 長谷川秀樹
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: 横浜
• [Presentation] MOLECULAR CHAPERON INHIBITOR-BASED TREATMENT AGAINST ATL : ITS IN VITRO AND IN VIVO EVALUATION XV (2011)
  • Author(s): Hidekatsu Iha, Emi Ikebe, Akira Kawaguchi, Shinya Taguchi, Akira Nishizono, Yuetsu Tanaka, Hirofumi Sawa, Masao Ogata, Mitsuo Hori, Jun-Ichi Fujisawa, Hideki Hasegawa
  • Organizer: International Congress of Virology
  • Place of Presentation: Sapporo
• [Presentation] MOLECULAR CHAPERON INHIBITOR-BASED TREATMENT AGAINSTATL : ITS IN VITRO AND IN VIVO EVALUATION (2011)
  • Author(s): Hidekatsu Iha, Emi Ikebe, Akira Kawaguchi, Shinya Taguchi, Akira Nishizono, Yuetsu Tanaka, Hirofumi Sawa, Masao Ogata, Mitsuo Hori, Jun-Ichi Fujisawa, Hideki Hasegawa
  • Organizer: XV International Congress of Virology
  • Place of Presentation: Sapporo
• [Presentation] 分子シャペロン阻害剤によるTaxとTax結合蛋白質の機能相関性に対する抑制的影響 (2010)
  • Author(s): 池辺詠美、川口晶、田口慎也、川嶋太郎、田中勇悦、堀光雄、澤洋文、西園晃、長谷川秀樹、伊波英克
  • Organizer: 第58回日本ウイルス学会学術集会
  • Place of Presentation: 徳島
• [Presentation] CXCR4アンタゴニスト(AMD3100)を用いたSCIDマウスにおける Tax トランスジェニックマウス由来腫瘍細胞の組織浸潤抑制 (2009)
  • Author(s): 川口晶、辻隆裕、大場靖子、木村享史、相内章、伊波英克、緒方正男、佐多徹太郎、澤洋文、長谷川秀樹
  • Organizer: 第57回日本ウイルス学会学術集会
  • Place of Presentation: 東京
• [Presentation] Therapeutic effect of novel NF-kappa B inhibitor, Bay65-1942, in mouse ATLL model (2009)
  • Author(s): Tsuji T, Kanbe M, Ainai A, Okamoto T, Sata T, Hall W.W, Hasegawa H
  • Organizer: 14th International Conference of Human Retrovirology : HTLV and related retroviruses
  • Place of Presentation: Salvador, Brazil
• [Presentation] Inhibition of the SDF-1α-CXCR4 axis by the CXCR4 antagonist AMD3100 suppresses the migration of human ATLL cells and murine lymphoblastoid cells from HTLV-I Tax transgenic mice (2009)
  • Author(s): Kawaguchi A, Orba Y, Kimura T, Iha H, Ogata M, Tsuji T, Sata T, Okamoto T, Hall W.W., Sawa H, Hasegawa H.
  • Organizer: 14th International Conference of Human Retrovirology : HTLV and related retroviruses
  • Place of Presentation: Salvador, Brazil